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| 1 | Coarctation of the aorta:Management from infancy to adulthood显示文摘Coarctation of the aorta is a relatively common form of congenital heart disease, with an estimated incidence of approximately 3 cases per 10000 births. Coarctation is a heterogeneous lesion which may present across all age ranges, with varying clinical symptoms, in isolation, or in association with other cardiac defects. The first surgical repair of aortic coarctation was described in 1944, and since that time, several other surgical techniques have been developed and modified. Additionally, transcatheter balloon angioplasty and endovascular stent placement offer less invasive approaches for the treatment of coarctation of the aorta for some patients. While overall morbidity and mortality rates are low for patients undergoing intervention for coarctation, both surgical and transcatheter interventions are not free from adverse outcomes. Therefore, patients must be followed closely over their lifetime for complications such as recoarctation, aortic aneurysm, persistent hypertension, and changes in any associated cardiac defects. Considerable effort has been expended investigating the utility and outcomes of various treatment approaches for aortic coarctation, which are heavily influenced by a patient's anatomy, size, age, and clinical course. Here we review indications for intervention, describe and compare surgical and transcatheter techniques for management of coarctation, and explore the associated outcomes in both children and adults. | Rachel D Torok Michael J Campbell Gregory A Fleming Kevin D Hill | 2015 | World Journal of Cardiology2015，7，11： | 27 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 4 | Decorin treatment for reversing trabecular meshwork fibrosis in open-angle glaucoma显示文摘In this perspective,we discuss the use of an anti-fibrotic agent Decorin to treat established fibrosis associated with glaucoma originally published by Hill et al.(2015).Glaucoma describes a group of progressive optic neuropathies that have the potential to cause irreversible blindness,for | Lisa J Hill Zubair Ahmed Ann Logan | 2016 | Neural Regeneration Research2016，11，6： | 3 |
| 5 | Update on nutritional status,body composition and growth in paediatric inflammatory bowel disease显示文摘Growth and nutritional status are important issues in paediatric inflammatory bowel disease(IBD).While linear growth is easy to assess,nutritional status is more complicated,with reports often compromised by the use of simple measures,such as weight and the body mass index,to assess nutritional status rather than more appropriate and sophisticated techniques to measure body composition.This review is an update on what is currently known about nutritional status as determined by body composition in paediatric IBD.Further,this review will focus on the impact of biologics on growth in paediatric IBD.Significant lean mass deficits have been reported in children with IBD compared with controls,and there is evidence these deficits persist over time.Furthermore,data imply that gender differences exist in body composition,both at diagnosis and in response to treatment.With respect to growth improvements following treatment with biologics,there are conflicting data.While some studies report enhancement of growth,others do not.The relationship between disease severity,impaired growth and the requirement for biologics needs to be considered when interpreting these data.However,key features associated with improvements in growth appear to be successful clinical response to treatment,patients in early stages of puberty,and the presence of growth failure at the onset of treatment. | Rebecca J Hill | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 6 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 7 | Polyoxometalates in medicine显示文摘 | Rhule J T Hill C L Judd D A | | 0，，： | 2 |
| 8 | Manufacture of large glass honeycomb mirrors显示文摘 | ANGEL J R P HILL J M | 1982 | SPIE1982，332，： | 2 |
| 9 | The crystal structure of the antimicrobial defensin HNP-3, an amphilic dimmer, suggests mechanisms of membrane permeabilization显示文摘 | Hill CP Yee J Selsted ME | 1991 | Science1991，251，： | 2 |
| 10 | Streptococcus suis serotypes characterized by analysis of chaperonin 60 gene sequences显示文摘 | Rousseau R Hill J E Prefontaine G | 2001 | Appl Env Microbiol2001，67，： | 2 |
| 11 | Anti-hypertensive drugs in children and adolescents显示文摘Worldwide the prevalence of essential hypertension inchildren and adolescents continues to increase. Tradi-tionally providers have used 'off-label' drugs to treatpediatric hypertension, meaning that rigorous clinicaltrials of these drugs have not been specifically per-formed in pediatric patient populations. Consequentlyproviders have extrapolated dosing, safety and efficacyfrom trials in adults. This practice is sub-optimal as chil-dren demonstrate unique differences in drug metabo-lism and response. Use of unstudied or understudieddrugs increases risk of adverse events and/or can leadto sub-optimal efficacy. Recognizing these concerns,regulatory agencies have created financial incentivesfor industry to conduct pediatric clinical trials. Theseincentives, coupled with the emerging pediatric hyper-tension epidemic, have spurred over 30 clinical trialsof anti-hypertensive drugs over the past 15 years andhave resulted in labeling of 10 new drugs by the UnitedStates Food and Drug Administration for treatment ofhypertension in children and adolescents. Unfortunatelythe financial incentive structures focus on newer drugsand drug classes. Consequently there is now a relativedearth of trial data for older but sometimes commonlyprescribed pediatric antihypertensive drugs. This article reviews recent pediatric antihypertensive drug trials with a focus on trial design and endpoints, drug dosing, safety, efficacy and specific drug indications. We also review the available data and experience for some of the more commonly prescribed, but less well studied 'older' pediatric antihypertensive drugs. | Patricia Y Chu Michael J Campbell Stephen G Miller Kevin D Hill | 2014 | World Journal of Cardiology2014，6，5： | 2 |
| 12 | 气缸孔粗糙度对机油耗影响的试验研究显示文摘侧重于内燃机机油耗控制中的一个重要因素。以前的研究工作已经通过理论或试验方法建立了气缸孔粗糙度与机油耗之间的关系。在本研究中,利用回归分析和新的瞬态放射性示踪剂机油耗测量法所得到的试验数据用统计学方法推导出了一个数学模型。该模型可预测机油耗随气缸孔粗糙度变化的期望值,并能提出确定和控制最低机油耗的重要气缸孔表面粗糙度参数。 | Hill S H Kantola T C Brown J R 孙书麒 | 1998 | 国外内燃机1998，30，3： | 2 |
| 13 | Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro 显示文摘 | Fan J M Ng Y Y Hill P A | 1999 | Kidney Int1999，56，4： | 2 |
| 14 | A study of the bubble to slug transition in vertical gas-liquid flow in columns of different diameter显示文摘 | Cheng H Hills J H | 1997 | Int J of Multiphase flow1997，42，3： | 2 |
| 15 | A robust adaptive backstepping and small-gain approach to adaptive output feedback control 显示文摘 | Jiang Z P Hill D J | 1999 | IEEE Transactions on Automatic Control1999，44，9： | 1 |
| 16 | Multiple DNA glycosylas es for repair of 8-oxoguanine and their potential in vivo functions 显示文摘 | Hazra T K Hill J W Izumi T | 2001 | Prog Nucleic Acid Res Mol Biol2001，68，： | 1 |
| 17 | Cognitive strategies and learning from the world wide Web 显示文摘 | Hill J R Hannafin M J | 1997 | Educational Technology Research and Development1997，45，4： | 1 |
| 18 | Bifurcation phenomena in the plane tension test显示文摘 | Hill R Hutchinson J W | 1975 | Mechanics and Physics of Solids1975，16，23： | 1 |
| 19 | High-efficiency Agrobacterium-mediated transformation of Brachypodium distachyon inbred line Bd21-3 显示文摘 | Vogel J Hill T | 2008 | Plant Cell Report2008，27，： | 1 |
| 20 | Arabidopsis onset of leaf death mutants identify a regulatory pathway controlling leaf senescence显示文摘 | Jing H C Sturre M J Hille J | 2002 | Plant J2002，32，1： | 1 |
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