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| 1 | Apoptosis induced by titanium dioxide nanoparticles in cultured murine microglia N9 cells显示文摘Owing to the rapidly increasing output of nano-scale titanium dioxide(TiO2) particles,their potential risk for central nerve system(CNS) has elicited much concern recently.Microglia is the resident macrophage in CNS and essential for the homeostasis of the CNS microenvironment.They are supposed to response to nanoparticles depositing in the brain tissues.Therefore,we investigated the cytotoxic effects of TiO2 NPs on microglia N9 cells in vitro.Results of propidium iodide/fluorescein diacetate(PI/FDA) double staining and MTT test clearly showed that TiO2 NPs more efficiently affected the viability of microglia N9 cells.Further Hoechst 33258 staining and flow cytometric analysis proved that nano-scale but not normal scale TiO2 induced apoptosis in vitro.These data suggest that TiO2 NPs can elicit apoptosis of N9 cells in vitro and thus present a potential risk for CNS. | LI XiaoBo XU ShunQing ZHANG ZhiRen Hermann J Schluesener | 2009 | Chinese Science Bulletin2009，54，20： | 2 |
| 2 | TLR配体对大鼠脊髓神经干细胞增殖的影响显示文摘目的研究某些ToU样受体(TLR)的配体对脊髓神经干细胞(NPCs)增殖的影响。方法大鼠经单次腹腔注射TLR不同配体,用BrdU跟踪标记增殖的NPCs。结果硫代磷酸含CpG的寡核苷酸(PSCpG-ODN)未引起脊髓NPCs的明显增殖,而PolyI:C、LPS与R848可引起BrdU^+细胞显著性增加。注射PolyI:C或R848的大鼠脊髓BrdU^+细胞密度于注射后2~3 d达最高,随后快速降至正常水平。伴随NPCs增殖的还有中枢神经系统(CNS)先天免疫系统的激活,如神经小胶质细胞的活化。结论某些TLR的配体被TLR识别后可能参与脊髓内正常神经细胞的发生过程,提示机体的先天免疫反应可能与组织再生过程紧密相关,对开发促进脊髓损伤再生修复的药剂来说是一有价值的工具。 | 苏艳华 张志仁 王先良 Hermann J Schluesener 徐顺清 | 2006 | 中华神经医学杂志2006，5，7： | 2 |
| 3 | Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document显示文摘 | Giuseppe Mancia Stéphane Laurent Enrico Agabiti-Rosei Ettore Ambrosioni Michel Burnier Mark J Caulfield Renata Cifkova Denis Clément Antonio Coca Anna Dominiczak Serap Erdine Robert Fagard Csaba Farsang Guido Grassi Hermann Haller Anthony Heagerty Sverre | 2009 | Journal of Hypertension2009，，： | 2 |
| 4 | New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP显示文摘 | Holger M. Koch Hermann M. Bolt Ralf Preuss Jürgen Angerer | 2005 | Archives of Toxicology2005，，7： | 2 |
| 5 | Prenatal 3D ultrasound diagnostics in cleidocranial dysplasia显示文摘 | Hermann NV Hove HD Jφrgensen C | | 0，，01： | 1 |
| 6 | Multiple Zircon Growth During Fast Exhumation of Diamondifer- ous,Deeply Subducted Continental Crust (Kokchetav Massif Kazakhstan) 显示文摘 | HERMANN J RUBATTO D KORSAKOV A | 2001 | Contribution to Mineralogy and Petrology2001，141，1： | 1 |
| 7 | Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit 显示文摘 | Ruf S Hermann M Berger I J | 2001 | Natl Biotechn2001，19，9： | 1 |
| 8 | Nonlinear Controllability and Observability显示文摘 | Hermann R Krener A J | 1977 | IEEE Trans Aurora Control1977，22，5： | 1 |
| 9 | Children with new-onset epilepsy: neuropsychological status and brain structure显示文摘 | Hermann B Jones J Sheth R | 2006 | Brain2006，129，： | 1 |
| 10 | Adaptive recognition by nucleic acidaptamers显示文摘 | Hermann T Patel D -J | 2000 | Science2000，287，： | 1 |
| 11 | Multiple zircon growth during fast exhumation of diamondiferous, deeply subducted continental crust (Kokchetav Massif, Kazakhstan)显示文摘 | Hermann J Rubatto D Korsakov A | 2001 | Contributions to Mineralogy and Petrology2001，141，： | 1 |
| 12 | Towards model checking stochastic process algebra显示文摘 | HERMANNS H KATOEN J P MEYER-KAYSER J | 2000 | Computer Science2000，1945，： | 1 |
| 13 | Pancreaticstellate cells form a niche for cancer stem cells and promotetheir self-renewal and invasiveness显示文摘 | Lonardo E Frias-Aldeguer J Hermann PC | 2012 | Cell Cycle2012，11，7： | 1 |
| 14 | 查看详情显示文摘 | Haynam C A Wegner P J Auerbach J M Bowers M W Dixit S N Erbert G V Heestand G M Henesian M A Hermann M R Jancaitis K S Manes K R Marshall C D Mehta N C Menapace J Moses E Murray J R Nostrand M C Orth C D Patterson R SacksR A Shaw M J Spaeth M Sutton S B W | | 0，，： | 1 |
| 15 | Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers 显示文摘 | Egan T D Minto C F Hermann D J | 1996 | Anesthesiology1996，84，4： | 1 |
| 16 | Estimated radiation dose associated with cardiac CT angiography显示文摘 | Hausleiter J Meyer T Hermann F | 2009 | JAMA2009，301，5： | 1 |
| 17 | Multiple resistance mechanisms in acute nonlymphoblastic leukemia (ANLL)显示文摘 | Sauerbrey A Zintl F Hermann J | 1998 | Anticancer Res1998，18，2： | 1 |
| 18 | The Oblique-plate Impact Experiment显示文摘 | Abou-Sayed Clifton R J Hermann L | 1976 | Experimental Mechanics1976，，4： | 1 |
| 19 | Adaptive recognition by nucleic acid aptamers显示文摘 | Hermann T Patel D J | 2000 | Seience2000，287，5454： | 1 |
| 20 | Gadolinium(Ⅲ) complexes as MRI contrast agents:Ligand design and properties of the complexes显示文摘 | HERMANN P KOTEK J KUBICEK V | 2008 | Dalton Transactions2008，21，23： | 1 |
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