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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Guided Image Filtering显示文摘 | HE K M SUN J TANG X O | 2013 | IEEE Transactions on Pattern Analysis and Machine Intelligence2013，35，6： | 1 |
| 3 | Atmospheric mercury deposition in Guizhou, China显示文摘 | Tan H He J L Liang L Lazoff S Sommer J Xiao Z F Lindqvist O | 2000 | The Science of the Total Environment2000，259，13： | 1 |
| 4 | A current sensor based on the giant magnetoresistance effect: Design and potential smart grid applications显示文摘 | YONG O Y HE J L HU J | 2012 | Sensors2012，12，15： | 1 |
| 5 | Atmospheric mercury deposition on Fanjing Mountain Nature Reserve, Guizhou, China显示文摘 | Xiao Z F Sommar J Lindqvist O Hong T He J L | 1998 | Chemosphere1998，36，10： | 1 |
| 6 | Distribution of phosphorus in soil aggregate fractions and its significance with regard to phosphorus transport in agricultural runo显示文摘 | He Z L Wilson M J Campbell C O | 1995 | Water Air and Soil Pollution1995，83，12： | 1 |
| 7 | Single image haze removal using dark channel prior 显示文摘 | HE K M SUN J TANG X O | 2011 | IEEE Transactions onPattern Analysis and Machine Intelligence ?2011，33，12： | 1 |
| 8 | FOXO3A genotype is strongly associated with human longevity显示文摘 | Willcox B J Donlon T A He O | 2008 | PNAS2008，105，13： | 1 |
| 9 | A novel method for re-spiratory motion gated with geometric sensitivity of the scan-ner in 3D PET 显示文摘 | He J F O'Keefe G J Gong S J | 2008 | IEEE Trans Nuclear Science2008，55，5： | 1 |
| 10 | Guided image filtering显示文摘 | He K M Sun J Tang X O | | 0，，6： | 1 |
| 11 | Guided image filtering显示文摘 | He K M Sun J Tang X O | 2013 | IEEE Transactions on Pattern Analysis and Machine Intelligence2013，35，6： | 1 |
| 12 | Single Image HAZE Removal Using Dark Channel Prior显示文摘 | He K M Sun J Tang X O | 2011 | IEEE Transactions on Pattern Analysis and Ma- chine2011，33，12： | 1 |
| 13 | Guided image filtering 显示文摘 | HE K M SUN J TANG X O | 2013 | IEEE Transactions on Pattern Analysis and MachineIntelligence2013，35，6： | 1 |
| 14 | Antibody Regulation ofT Cell Immunity: Implications for Vaccine Strategies against Intracellular Pathogens 显示文摘 | Igietseme J U Eko F O He Q | 2004 | Expert Review of Vaccines2004，3，1： | 1 |
| 15 | Guided Image Filtering显示文摘 | He K M Sun J Tang X O | 2013 | IEEE Transactions on Pattern Analysis and MA2013，35，6： | 1 |
| 16 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 17 | Guided image filtering显示文摘 | HE K M SUN J TAND X O | 2013 | IEEE Transactions on Pattern Analysis and Machine Intelligence2013，35，6： | 1 |
| 18 | MicroRNA expression profiling in human ovarian cancer:miB-214 induces cell survival and cisplatin resistance by targeting PTEN显示文摘 | Yang H Kong W He L Zhao JJ O'Donnell JD Wang J | | 0，，： | 1 |
| 19 | Guide image filtering显示文摘 | HE K M SUN J TANG X O | 2013 | IEEE Transactions on Pattern Analysis and Machine Intelligence2013，35，6： | 1 |
| 20 | Generation of insulin-secreting islet-like clusters from human skin fibroblasts显示文摘 | Tateishi K He J Taranova O | 2008 | J Biol Chem2008，283，31： | 1 |
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