|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CTLA4 Silencing with siRNA Promotes Deviation of Th1/Th2 in Chronic Hepatitis B Patients显示文摘To determine whether RNA interference (RNAi) could block cytotoxic T-lymphocyte antigen 4 (CTLA4) in human lymphocytes in vitro and promote IFN-γ and IL-2 secretions, three small interfering RNAs (siRNAs) were selected based on target specificity sequences of human CTLA4 and transfected into human lymphocytes of chronic HBV patients. As a result, the expression of human CTLA4 mRNA was efficiently suppressed by all the three siRNAs. Compared with negative control (siRNA-co), siRNA-1 inhibited the expression of CTLA4 most efficiently and was used in the further study. The expressions of IFN-γ and IL-2 were upregulated and the level of IL-4 was almost unchanged in lymphocytes transfected with siRNA-1 compared with the blank control. These results indicated that siRNA-1 led to IFN-γ and IL-2 secretions, which is a main response of Th1/Th2. In a conclusion, RNAi significantly suppressed the expression of human CTLA4 mRNA in human lymphocytes in vitro, and could induce Th1/Th2 response. It could be a new therapeutic strategy for chronic HBV infection. | Yongsheng Yu Hao Wu Zhenghao Tang Guoqing Zang | 2009 | Cellular & Molecular Immunology2009，6，2： | 14 |
| 2 | Microstructure,mechanical and corrosion properties of Mg-2Dy-xZn(x=0,0.1,0.5 and 1 at.%)alloys显示文摘Microstructure,mechanical and corrosion properties of as-cast Mg-2Dy-xZn(x=0,0.1,0.5,and 1)(at.%)alloys were investigated.The microstructures of the as-cast Mg-2Dy and Mg-2Dy-0.1Zn alloys mainly consisted ofα-Mg phase and Mg_(24)Dy_(5)eutectic phase.With 0.5 at.%Zn addition,Mg_(12)ZnDy phase with 18R-type long period stacking ordered(LPSO)structure and Mg_(2)Dy phase precipitated at the grain boundaries.When the content of Zn is 1 at.%,only the Mg_(3)Zn_(3)Dy_(2)phase formed in theα-Mg matrix.The electrochemical measurements and immersion testing results indicated that the Mg-2Dy-0.1Zn alloy exhibited the best corrosion resistance.It revealed that the morphology,scale,amount and distribution of the second phase have a great effect on the corrosion resistance of alloy.Additionally,the tensile testing results showed that the Mg-2Dy-0.5Zn alloy exhibited the higher tensile strength and good elongation,especially at 200℃.The improvement of mechanical properties was mainly due to the strengthening of LPSO phase and grain refinement of α-Mg. | Guangli Bi Yuandong Li Shijun Zang Jianbin Zhang Ying Ma Yuan Hao | 2014 | Journal of Magnesium and Alloys2014，2，1： | 13 |
| 3 | New Discovery of Holocene Activity along the Weixi-Qiaohou Fault in Southeastern Margin of the Tibetan Plateau and its Neotectonic Significance显示文摘Objective The lateral extrusion eastward of the Tibetan Plateau leads to the formation of the Sichuan-Yunnan block,which is the most representative active block in the southeastern margin of the Tibetan Plateau,characterized by strong and frequent seismicity (Li Ping et al.,1975;Zhang Peizhen et al.,2003;Li Yong et al.,2017). | CHANG Zufeng ZANG Yang and CHANG Hao | 2018 | Acta Geologica Sinica(English Edition)2018，92，6： | 8 |
| 4 | Response of the sediment geochemistry of the Changjiang River(Yangtze River) to the impoundment of the Three Gorges Dam显示文摘Based on the measurement of major and trace elements in suspended sediments in the low reaches of the Changjiang River during throughout a whole hydrologic year, the origins, seasonal variations, and fluxes of multielements and the human impacts on multielements transport processes have been analyzed along with the influence of weathering in the Changjiang River basin. The results show that most element contents were high in both autumn and winter and low in summer, which was largely caused by the dilution of discharge. Weathering detritus in the Changjiang River basin is the main source of most elements in suspended sediments. However, riverine pollution could bring more loadings of Cd, Pb, As and Zn into river water than it did a few decades ago. The annual average fluxes of Cd, Pb and Zn, which are major contamination elements, to the sea were 179 ± 21 tons/year, 7810 ± 675 tons/year, and 12,000 ± 1320 tons/year,respectively, in which approximately 8.7%, 11.9% and 2.7% of their loadings, respectively,were contributed by pollution inputs. Element exports mainly occurred in the summer(44.4%–57.4%) in the lower part of the Changjiang River. A general relationship between sediment retention and element content suggests a positive feedback mechanism for the decreased number of particles, in which element riverine loadings are reduced due to the enhanced trapping effect by the Three Gorges Dam(TGD). Compared to those in 1980,current element shares of the Changjiang River compared to the global budget have declined due to the construction of the TGD. | Hao Wang Xiangbin Ran Jingxi Li Jun Liu Wentao Wu Menglu Li Jiaye Zang | 2019 | Journal of Environmental Sciences2019，31，9： | 6 |
| 5 | Dielectric metalens for miniaturized imaging systems:progress and challenges显示文摘Lightweight, miniaturized optical imaging systems are vastly anticipated in these fields of aerospace exploration, industrial vision, consumer electronics, and medical imaging. However, conventional optical techniques are intricate to downscale as refractive lenses mostly rely on phase accumulation. Metalens, composed of subwavelength nanostructures that locally control light waves, offers a disruptive path for small-scale imaging systems. Recent advances in the design and nanofabrication of dielectric metalenses have led to some high-performance practical optical systems. This review outlines the exciting developments in the aforementioned area whilst highlighting the challenges of using dielectric metalenses to replace conventional optics in miniature optical systems. After a brief introduction to the fundamental physics of dielectric metalenses, the progress and challenges in terms of the typical performances are introduced. The supplementary discussion on the common challenges hindering further development is also presented, including the limitations of the conventional design methods, difficulties in scaling up, and device integration. Furthermore, the potential approaches to address the existing challenges are also deliberated. | Meiyan Pan Yifei Fu Mengjie Zheng Hao Chen Yujia Zang Huigao Duan Qiang Li Min Qiu Yueqiang Hu | 2022 | Light(Science & Applications)2022，11，8： | 3 |
| 6 | Apigenin accelerates lipopolysaccharide induced apoptosis in mesenchymal stem ceils through suppressing vitamin D receptor expression显示文摘mensenchymal 干细胞( MSC )的背景移植为织物 engineering.However 作为一个有希望的方法被建议了,为移植的 MSC 的申请将由于象过多的 inflammation.Apigenin ( API )那样的极其严厉的微型环境经历 apoptosis 被报导了由展出我们调查了的反煽动性、抗氧化的 capacity.Here 保护房间免于煽动性的损坏和房间死亡在 lipopolysaccharide ( LPS )的 API 的调节效果调停了然而,它能减少在在 MSC 的不同时间点的 COX-2 , iNOS 和 NF-KB 的 mRNA 表示由 LPS 导致了,除了在从阶段对比显微镜学的 5 mol/L.Results 的集中的 API , MTT ,染色的 Hoechst 和 AnnexinV/PI 加倍表明的污点 FCM 与 API 的增加的集中和管理时间的扩展, MSC 的重要词法变化发生了,房间的生存能力强烈被禁止,并且同时, 管理LPS 的 MSC 的 apoptosis 被加重, | ZHANG Huan-tian ZHA Zhen-gang CAO Jia-hui LIANG Zu-jian WU Hao HE Ming-tao ZANG Xiao YAO Ping ZHANG Jia-qing | 2011 | Chinese Medical Journal2011，，21： | 3 |
| 7 | Transgenic Arabidopsis thaliana expressing a wheat oxalate oxidase exhibits hydrogen peroxide related defense response显示文摘Oxalic acid(OA) is considered as an important pathogenetic factor of some destructive diseases caused by some fungal pathogens such as Sclerotinia sclerotiorum. Oxalate degradation is important for plant health, and plants that contain oxalate oxidase(OXO) enzymes could breakdown oxalate into CO_2 and H_2O_2, which subsequently evokes defense responses. However, some species, such as Arabidopsis thaliana, have no oxalate oxidase activity identified to date. The present study aims to develop transgenic Arabidopsis expressing a wheat oxalate oxidase, to test for the response to OA exposure and fungal infection by S. sclerotiorum. The results showed that the transgenic Arabidopsis lines that expressed the wheat OXO exhibited enhanced resistance to OA exposure and S. sclerotiorum infection in the tolerance assays. In the same manner, it could convert OA to CO_2 and H_2O_2 to a higher extent than the wild-type. Intensive osmotic adjustments were also detected in the transgenic Arabidopsis lines. The higher level of produced H_2O_2 subsequently induced an elevated activity of antioxidant enzymes including superoxide dismutase(SOD) and peroxidase(POD) in the transgenic Arabidopsis plants. The present study indicated that the expression of a gene encoding wheat OXO could induce intensive osmotic adjustments and hydrogen peroxide related defense response, and subsequently increased tolerance to S. sclerotiorum in transgenic A. thaliana. | WEI Fang HU Jie YANG Yan HAO Zhi-da WU Rui-hua TIAN Bao-ming CAO Gang-qiang ZANG Xin | 2015 | Journal of Integrative Agriculture2015，14，12： | 2 |
| 8 | Discussion on Spatial Optimization Modeling of Water Resource Conservation Forests and Management Practice of Forest Functions显示文摘According to the unification principle of system structure and system function of the Water Resource Conservation Forests,seven factors were selected from stand spatial structure,trees structure and healthy of woods,the multifunction management optimization model target was confirmed by using nonlinearity multi-objective programming approach, and the target function-stand spatial structure homogeneity index was defined to establish spatial optimization models with restraining conditions set up in diversity of stand structure and spatial structure.The spatial structure of available typical stand in the wet land area in southern Donting Lake was optimized by means of selective cutting and reinforcement planting.The results showed that the spatial structure was improved obviously and trees diversity and stand health were not weakened.It’s suggested that the established optimization model can effectively guide multifunction management,stand structure optimization and the steadiness of ecological ecosystem and it is convenient and operable in practice,and it’s very important to protect and recover ecosystem of Water Resource Conservation Forests. | Li Jianjun Zhang Huiru Wang Chuanli Zang Hao Cao Xupeng | 2012 | Chinese Forestry Science and Technology2012，11，3： | 1 |
| 9 | Serum high expression of miR-214 and miR-135b as novel predictor for myeloma bone disease development and prognosis显示文摘 | Hao M Zang M Zhao L | 2016 | Oncotarget2016，7，19： | 1 |
| 10 | Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis显示文摘Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer metastasis, accompanied with vast epigenetic changes.AMP-activated protein kinase (AMPK), a cellular energy sensor, plays regulatory roles in multiple biological processes. Although afew studies have shed light on AMPK regulating cancer metastasis, the inside epigenetic mechanisms remain unknown. Herein weshow that AMPK activation by metformin relieves the repressive H3K9me2-mediated silencing of epithelial genes (e.g., CDH1)during EMT processes and inhibits lung cancer metastasis. PHF2, a H3K9me2 demethylase, was identified to interact with AMPKα2.Genetic deletion of PHF2 aggravates lung cancer metastasis and abolishes the H3K9me2 downregulation and anti-metastasis effectof metformin. Mechanistically, AMPK phosphorylates PHF2 at S655 site, enhancing PHF2 demethylation activity and triggering thetranscription of CDH1. Furthermore, the PHF2-S655E mutant that mimics AMPK-mediated phosphorylation status further reducesH3K9me2 and suppresses lung cancer metastasis, while PHF2-S655A mutant presents opposite phenotype and reverses the antimetastasiseffect of metformin. PHF2-S655 phosphorylation strikingly reduces in lung cancer patients and the higherphosphorylation level predicts better survival. Altogether, we reveal the mechanism of AMPK inhibiting lung cancer metastasis viaPHF2 mediated H3K9me2 demethylation, thereby promoting the clinical application of metformin and highlighting PHF2 as thepotential epigenetic target in cancer metastasis. | Ying Dong Hao Hu Xuan Zhang Yunkai Zhang Xin Sun Hanlin Wang Weijuan Kan Min-jia Tan Hong Shi Yi Zang Jia Li | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 11 | Downregulated miR-33b is a novel predictor associated with disease progression and poor prognosis in multiple myeloma显示文摘 | Fei Li Mu Hao Xiaoyan Feng Meirong Zang Yu Qin Shuhua Yi Zengjun Li Yan Xu Lili Zhou Weiwei Sui Shuhui Deng Dehui Zou Fenghuang Zhan Lugui Qiu | 2015 | Leukemia Research2015，，7： | 1 |
| 12 | Low serum mi R ‐19a expression as a novel poor prognostic indicator in multiple myeloma显示文摘 | Mu Hao Meirong Zang Erik Wendlandt Yan Xu Gang An Dasen Gong Fei Li Fang Qi Yanru Zhang Ye Yang Fenghuang Zhan Lugui Qiu | 2015 | Int. J. Cancer2015，，8： | 1 |
| 13 | Detection of re- spiratory syncytial virus fusion protein variants between 2009 and 2012 in China显示文摘 | Xia Q Zhou L Peng C Hao R Ni K Zang N Ren L Deng Y Xie X He L Tian D Wang L Huang A Zhao Y Zhao X Fu Z Tu W Liu E | 2014 | Arch Virol2014，159，5： | 1 |
| 14 | Performance of Emulsified Asphalt Full Thickness Cold Recycling Subgrade Materials显示文摘 | Jun Xiao Li Xiao Bo Yin Jian Yuan He Chao Zang Zong Rui Hao | 2014 | Advanced Materials Research2014，，915： | 1 |
| 15 | Low serum miR -19a ex- pression as a novel poor prognostic indicator in multiple myeloma 显示文摘 | Hao M Zang M Wendlandl E | 2015 | Int J Cancer2015，136，8： | 1 |
| 16 | Low serum miR - 19a expression as a novel poor prognostic indicator in multiple myeloma 显示文摘 | Hao M Zang M Wendlandt E | 2015 | IntJ Cancer2015，136，8： | 1 |
| 17 | Improved tolerance of OsbHLH1 transgenic Arabidopsis to low temperature stress显示文摘 | Wang Y J Hao Y J Dai J X Du B Zang J S Chen S Y | 2004 | Chinese High Technology Letters2004，14，4： | 1 |
| 18 | Synthesis, sepa ration and biodistribution of ^99Tc^m-CO-MJBI corn plex显示文摘 | Hao GY Zang JY Zhu L | 2004 | J Label Compd Radiopharm2004，47，： | 1 |
| 19 | Chemical sand stabilization: A review of material, mechanism, and problems显示文摘 | Zang Yunxiao Gong Wei Xie Hao | 2015 | Environmental Technology Reviews2015，4，1： | 1 |
| 20 | Low power NOC process element mapping-using genetic algorithm显示文摘 | Zang Mingxiang You Hao | 2012 | Computer Science2012，9，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员