|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Grazing effects on herbage nutritive values depend on precipitation and growing season in Inner Mongolian grassland显示文摘Aims Grasslands are widely used for production of livestock,which depend on the nutritive value of herbage species.However,there are still large uncertainties as to how grazing,precipitation and growing season interactively affect herbage nutritive value.Methods Here,based on a grazing experiment with seven grazing intensities in an Inner Mongolian grassland since the year 2005,we analysed nutritive value of four dominant grass species from June to September in both a relatively wetter year(2008)and a drier year(2010).Herbage with high nutritive value is characterized by high concentration of crude protein,high concentration of cellulase digestible organic matter and low concentration of neutral detergent fibre.Important Findings We found that(i)grazing significantly increased the nutritive value of Leymus chinensis,Agropyron michnoi and Cleistogenes squarrosa but had minor effects on the nutritive value of Stipa grandis.(ii)For all species,nutritive values were greater in the wetter year than in the drier year and were greatest in the early growing season(June)and lowest at the end of the growing season(September).Inter-annual and inter-seasonal variations in nutritive value were much greater for L.chinensis and A.michnoi than for C.squarrosa and S.grandis,suggesting higher water use efficiency for the latter two species.(iii)Grazing significantly decreased the drought resistance of three species,but not of S.grandis.(iv)Grazing significantly increased inter-month variation in nutritive value for L.chinensis and A.michnoi but had relatively minor or no effects on that of C.squarrosa and S.grandis.Therefore,grazing effects on species nutritive values showed strong inter-annual and seasonal patterns,and species-specific responses might be related to species traits(i.e.water use efficiency,digestibility).Our results have important implications for ecosystem management of arid and semiarid grasslands under intense grazing and global climatic change. | Haiyan Ren Guodong Han Zhichun Lan Hongwei Wan Philipp Schönbach Martin Gierus Friedhelm Taube | 2016 | Journal of Plant Ecology2016，9，6： | 14 |
| 2 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 3 | β-diversity Patterns of Plant Community in Fragmented Habitat in a Degenerated Meadow in Songnen Plain,China显示文摘A number of isolated islands of Leymus chinensis + herbosa community were investigated in fragmented habitat islands,by Braun-Blanquet field survey approach,in a degenerated meadow in the Songnen Plain,China in 2007.These islands were classified as large,medium,and small scales on the basis of the island area(100-1000m2,large island;50-100m2,middle island;10-50m2,small island).Each scale of the investigation involved eight islands.The responses of β-diversity patterns of plant taxon to the habitat fragmentation at local community and metacommunity levels were analyzed on different scales of 24 isolated islands.The results indicated that at the local community level,there were 57 species belonging to 20 families and 49 genera in large islands,49 species belonging to 16 families and 40 genera in middle islands,and 27 species belonging to eight families and 23 genera in small islands.β-diversity indexes for species,genus and family in large,middle,and small islands varied greatly,and the highest value of the indexes was not noted in the largest island.However,the average of the data obtained at the three scales showed that across large islands,Whittaker indexes were low and Bray-Curtis similarity indexes were high,while across small islands,Whittaker indexes were high and Bray-Curtis similarity indexes were low.At the metacommunity level,Whittaker indexes for species and genus showed a great significantly negative double logarithmic correlation(p<0.01) with the island area,whereas the Bray-Curtis indexes for species,genus and family showed a great significantly positive double logarithmic correlation(p<0.01) with the island area.At both local community and metacommunity levels,turnovers of species and genus could respond more sensitively to spatial changes of plant diversity patterns than that of family.Hence,the species and the genus could be used for the analysis of β-diversity patterns of plant community. | HAN Dayong LI Haiyan YANG Yunfei | 2009 | Chinese Geographical Science2009，19，4： | 11 |
| 4 | Biological soil crust distribution in Artemisia ordosica communities along a grazing pressure gradient in Mu Us Sandy Land, Northern China显示文摘This study investigated the distribution pattern of biological soil crust (BSC) in Artemisia ordosica communities in Mu Us Sandy Land. Three experimental sites were selected according to grazing pressure gradient. In each experimental site, the total vegetation cover, A. ordosica cover, BSC cover, litter-fall cover, BSC degree of fragmentation, BSC thickness and soil properties were investigated in both fixed and semi-fixed sand dunes and simultaneously analyzed in the laboratory. The results showed that at the same grazing pressure, BSC cover and composition were significantly affected by the fixation degree of sand dunes. In addition, BSC cover in the fixed sand dunes was 83.74% on average, whereas it is proportionally dominated by 28% mosses, 21% lichens, and 51% algae. Meanwhile, BSC cover in the semi-fixed sand dunes was 23.54% on average, which is proportionally dominated by 6.3% mosses, 2.5% lichens, and 91.2% algae. Fine sand, organic matter, and total nitrogen (N) contents in the fixed sand dunes were all significantly higher than those in the semi-fixed sand dunes. Litter-fall cover decreased along the grazing pressure gradient, whereas BSC fragmentation degree increased. Fine sand content decreased along with the increase of grazing pressure, whereas medium sand content increased in both fixed and semi-fixed dunes. The organic matter and total N contents in the no grazing site were significantly higher than those in light and normal grazing sites. However, there were no significant differences between the light and normal grazing sites. In addition, there were also no significant differences in BSC thickness between the light and normal grazing sites in the fixed sand dunes. However, a significant decrease was observed in both BSC cover and thickness in the normal grazing site. The BSC in the semi-fixed dunes was more sensitive to disturbance. | JunHong ZHANG Bo WU YongHua LI WenBin YANG YaKai LEI HaiYan HAN Ji HE | 2013 | Journal of Arid Land2013，5，2： | 10 |
| 5 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 6 | The internalization pathway,metabolic fate and biological effect of superparamagnetic iron oxide nanoparticles in the macrophage-like RAW264.7 cell显示文摘The potential applications of superparamagnetic iron oxide nanoparticles (SPIONs) in several nanomedical fields have attracted intense interest based on the cell-nano interaction. However, the mechanisms underlying cell uptake, the intracellular trail, final fate and the biological effects of SPIONs have not yet been clearly elucidated. Here, we showed that multiple endocytic pathways were involved in the internalization process of SPIONs in the RAW264.7 macrophage. The internalized SPIONs were biocompatible and used three different metabolic pathways: The SPIONs were distributed to daughter cells during mitosis; they were degraded in the lysosome and free iron was released into the intracellular iron metabolic pool; and, the intact SPIONs were potentially exocytosed out of the cells. The internalized SPIONs did not induce cell damage but affected iron metabolism, inducing the upregulation of ferritin light chain at both the mRNA and protein levels and ferroportin 1 at the mRNA level. These results may contribute to the development of nanobiology and to the safe use of SPIONs in medicine when administered as a contrast medium or a drug delivery tool. | GU JingLi XU HaiFei HAN YeHua DAI Wei HAO Wei WANG Chun Yu GU Ning XU HaiYan CAO JiMin | 2011 | Science China(Life Sciences)2011，54，9： | 8 |
| 7 | MRS and diffusion tensor image in mild traumatic brain injuries显示文摘Objective:To analyze characters of magnetic resonance spectroscopy(MRS) and diffusion tensor imaging(DTI) in the diagnosis of mild trauma brain injuries(MTBI) in frontal lobe and to compare with conventional magnetic resonance imaging(MRI).Methods:A total of 21 patients were selected,who all aged 12-51 years old and had injury within 24 hours.Computer tomography (CT) and the Glasgow Coma Scale were used to evaluate the degree of injury.All patients were diagnosed as MTBI,and 19 had conventional MRI,MRS and DTI.The major parameters of MRS were Probe-P sequence,TE= 144 or 35 ms,and both single voxel spectrum and chemical shift imging were included.The major parameters of DTI were diffusion directions =15,b value = 1000 s/mm^2. Frational anisotropic(FA) map and average ADC map were obtained to evaluate DTI result. Positive deletion ratio was observed and the imaging changes were compared between injured side and normal side.Results:All 21 patients had CT scan and Glasgow scale.A total of 19 patients had conventional MRI.DTI and MRS.Results of CT and conventional MRI showed no significant abnormality in lobe,and Glasgow scale showed mild type.MRS result showed significant decrease in N-acetyl aspartate(NAA) and NAA/creatine(Cr) in 13 cases(68.4%) (P<0.001),and increase in lactic acid(Lac) in 7 cases(36.8%).FA mapping of the frontal lobe displayed significant changes in 7 cases(36.8%),with 5 out of the 7 cases having increase in FA value.And there was no significant difference in average ADC.Conclusions:MRS and DTI might be more sensible than other methods,such as CT and conventional MRI in diagnosis of MTBI.The particular changes were reduced NAA and increased Lac for MRS.and increased FA values for DTI. | Jing Chen Hu Jin Ying Zhang Qizhou Liang Haiyan Liao Ziyi Guo Xiangjun Han | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 6 |
| 8 | Brine-freeze-thaw Durability and Crack Density Model of Concrete in Salt Lake Region显示文摘The brine-freeze-thaw durability (defined as the durability under freeze-thaw cycles in Qinghai salt lake brine) of concrete (ordinary Portland cement concrete (OPC), high performance concrete (HPC-a), high performance concrete with steel fiber (HPC-b), and high performance concrete with high Young's modulus polyethylene fiber (HPC-c)) was systematically investigated by the relative dynamic elastic modulus, the relative mass, the appearance, the scanning electron microscopy, and the X-ray diffraction. In addition, the low-temperature physical and chemical corrosion mechanism and a crack density model after the modified relative dynamic elastic modulus being taken into consideration were proposed. The results show that the deterioration of OPC is the severest, followed by HPC-a, HPC-c and HPC-b. The admixture or the fiber is mixed into concrete, which can improve the brine-freeze-thaw durability of concrete. The critical mass growth of the failure of concrete is 3.7%. The cause of the deterioration of concrete under the brine-freeze-thaw cycles is physical and chemical corrosion, not freezing and thawing. The crack density model can effectively describe the deterioration evolution of concrete. | 巩位 余红发 MA Haiyan HAN Wenliang | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，3： | 5 |
| 9 | Altered Local Field Potential Relationship Between the Parafascicular Thalamic Nucleus and Dorsal Striatum in Hemiparkinsonian Rats显示文摘The thalamostriatal pathway is implicated in Parkinson's disease(PD); however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex(CM/Pf, or the Pf in rodents) and the dorsal striatum(DS) remain unclear.Therefore, we simultaneously recorded local field potentials(LFPs) in both the Pf and DS of hemiparkinsonian and control rats during epochs of rest or treadmill walking. The dopamine-lesioned rats showed increased LFP power in the beta band(12 Hz–35 Hz) in the Pf and DS during both epochs, but decreased LFP power in the delta(0.5 Hz–3 Hz) band in the Pf during rest epochs and in the DS during both epochs, compared to control rats. In addition,exaggerated low gamma(35 Hz–70 Hz) oscillations after dopamine loss were restricted to the Pf regardless of the behavioral state. Furthermore, enhanced synchronization of LFP oscillations was found between the Pf and DS after the dopamine lesion. Significant increases occurred in the mean coherence in both theta(3 Hz–7 Hz) and beta bands,and a significant increase was also noted in the phase coherence in the beta band between the Pf and DS during rest epochs. During the treadmill walking epochs, significant increases were found in both the alpha(7 Hz–12 Hz)and beta bands for two coherence measures. Collectively,dramatic changes in the relative LFP power and coherence in the thalamostriatal pathway may underlie the dysfunction of the basal ganglia-thalamocortical network circuits in PD, contributing to some of the motor and non-motor symptoms of the disease. | Haiyan Zhang Jing Yang Xuenan Wang Xiaomeng Yao Hongyu Han Yunfeng Gao Hongli Chang Tianyu Xiang Shuang Sun Yanan Wang Xiusong Wang Min Wang | 2019 | Neuroscience Bulletin2019，35，2： | 5 |
| 10 | Influencing factors and control measures of excavation on adjacent bridge foundation based on analytic hierarchy process and finite element method显示文摘Many uncertain factors in the excavation process may lead to excessive lateral displacement or overlimited internal force of the piles,as well as inordinate settlement of soil surrounding the existing bridge foundation.Safety control is pivotal to ensuring the safety of adjacent structures.In this paper,an innovative method is proposed that combines an analytic hierarchy process(AHP)with a finite element method(FEM)to reveal the potential impact risk of uncertain factors on the surrounding environment.The AHP was adopted to determine key influencing factors based on the weight of each influencing factor.The FEM was used to quantify the impact of the key influencing factors on the surrounding environment.In terms of the AHP,the index system of uncertain factors was established based on an engineering investigation.A matrix comparing the lower index layer to the upper index layer,and the weight of each influencing factor,were calculated.It was found that the excavation depth and the distance between the foundation pit and the bridge foundation were fundamental factors.For the FEM,the FE baseline model was calibrated based on the case of no bridge surrounding the foundation pit.The consistency between the monitoring data and the numerical simulation data for a ground settlement was analyzed.FE simulations were then conducted to quantitatively analyze the degree of influence of the key influencing factors on the bridge foundation.Furthermore,the lateral displacement of the bridge pile foundation,the internal force of the piles,and the settlement of the soil surrounding the pile foundation were emphatically analyzed.The most hazardous construction condition was also determined.Finally,two safety control measures for increasing the numbers of support levels and the rooted depths of the enclosure structure were suggested.A novel method for combining AHP with FEM can be used to determine the key influencing aspects among many uncertain factors during a construction,which can provide some beneficial references for engineering design and construction. | Shuangxi FENG Huayang LEI Yongfeng WAN Haiyan JIN Jun HAN | 2021 | Frontiers of Structural and Civil Engineering2021，15，2： | 5 |
| 11 | Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system显示文摘Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells(MSC) trapped in the lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as lung cancer-targeted drug delivery vehicles by loading nanoparticles(NP)with anti-cancer drug. MSC showed a higher drug intake capacity than fibroblasts. In addition, MSC showed predominant lung trapping in both rabbit and monkey. IR-780 dye, a fluorescent probe used to represent docetaxel(DTX) in NP, delivered via MSC accumulated in the lung. Both in vitro MSC/A549 cell experiments and in vivo MSC/lung cancer experiments validated the intercellular transportation of NP between MSC and cancer cells. In vivo assays showed that the MSC/NP/DTX drug delivery system exerted primary tumor inhibition efficiency similar to that of a NP/DTX drug system. Collectively, the MSC/NP drug delivery system is promising for lung-targeted drug delivery for the treatment of lung cancer and other lung-related diseases. | Xusheng Wang Haiyan Chen Xiaowei Zeng Wenpeng Guo Yu Jin Shan Wang Ruiyun Tian Yanjiang Han Ling Guo Jimin Han Yaojiong Wu Lin Mei | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 4 |
| 12 | A Near Infrared Cyanine-Based Fluorescent Probe for Highly Selectively Detecting Glutathione in Living Cells显示文摘包含 thiol 组的氨基酸在把生物氧化作为减小平衡起重要作用。由于 biothiols 的重要细胞的功能,开发有效方法检测 biothiols 在是必要的复杂化生物系统。在这个工作,我们发展了一基于花青荧光灯探查作为一个检测的组利用 thioether,它出现了荧光灯“刺激”向 GSH 和它的反应能被用作 biomarker 决定细胞的 GSH。 | Xiaole Sheng Dan Chen Meijiao Cao Yufeng Zhang Xie Han Xiaoqiang Chen Shenghua Liu Haiyan Chen Jun Yin | 2016 | Chinese Journal of Chemistry2016，34，6： | 3 |
| 13 | Mass loss and nutrient dynamics during litter decomposition in response to warming and nitrogen addition in a desert steppe显示文摘Plant litter decomposition has been studied extensively in the context of both warming and increased atmospheric nitrogen deposition. However, the temporal patterns of mass loss and nutrient release in response to warming and nitrogen addition remain unclear. A 2-year decomposition experiment aimed to examine the effects of warming and nitrogen addition on decomposition rate, and nitrogen and phosphorus dynamics. The effects of warming and nitrogen addition on decomposition of litter of Stipa breviflora, a dominant species in a desert steppe of northern China, were studied. Warming and nitrogen addition significantly enhanced litter mass loss by 10% and 16%, respectively, and moreover promoted nitrogen and phosphorus release from the litter in the first year of decomposition, followed by an immobilization period. The interactive effects of warming and nitrogen addition on mass loss, nitrogen and phosphorus concentrations of litter were also found during the decomposition. This study indicates that warming and nitrogen addition increased litter mass loss through altering litter quality. These findings highlight that interactions between climate change and other global change factors could be highly important in driving decomposition responses. | Haiyan REN Jie QIN Baolong YAN Alata Baoyinhexige Guodong HAN | 2018 | Frontiers of Agricultural Science and Engineering2018，5，1： | 3 |
| 14 | Simultaneous determination of doxorubicin and its dipeptide prodrug in mice plasma by HPLC with fluorescence detection显示文摘A simple and sensitive high performance liquid chromatography with fluorescence detection(HPLC–FD)has been developed for simultaneous quantification of doxorubicin(DOX) and its dipeptide conjugate prodrug(PDOX) in mice plasma.The chromatographic separation was carried out on an Amethyst C_(18)–H column with gradient mobile phase of 0.1% formic acid and 0.1% formic acid in acetonitrile at a flow rate of 1.0 mL/min.The excitation and emission wavelengths were set at 490 and 550 nm,respectively.The method was comprehensively validated.The limits of detection were low up to 5.0 ng/m L for DOX and 25.0 ng/m L for PDOX.And the limits of quantification were low up to 12.5 ng/m L for DOX and 50 ng/m L for PDOX,which were lower than those for most of the current methods.The calibration curves showed good linearity(R^2>0.999) over the concentration ranges.The extraction recoveries ranged from 84.0% to 88.2% for DOX and from 85.4% to 89.2% for PDOX.Satisfactory intra-day and inter-day precisions were achieved with RSDs less than 9.1%.The results show that the developed HPLC–FD method is accurate,reliable and will be helpful for preclinical pharmacokinetic study of DOX and PDOX. | Jing Han Jue Zhang Haiyan Zhao Yan Li Zilin Chen | 2016 | Journal of Pharmaceutical Analysis2016，6，3： | 3 |
| 15 | Effect of the Morphology of ZnO Support on the Desulfurization and Regeneration Performance of Ni/ZnO Catalyst显示文摘The Ni/ZnO desulfurization catalyst has been highly valued for its high desulfurization rate and low octane value loss. However, during the process of desulfurization, ZnO is prone to deactivation and the active component Ni is susceptible to agglomeration, which can affect the performance of the catalyst. In order to solve these problems, the modification of ZnO support has been extensively studied. The granular, short rod-shaped and nanowire-structured ZnO were synthesized by controlling the concentration of NaOH, and the desulfurization catalyst was prepared with ZnO serving as the support after loading of metallic Ni. The catalyst was characterized by X-ray diffraction, N2 adsorption-desorption, SEM, TEM and other analytical methods. The desulfurization performance of the catalyst was investigated with n-heptane - thiophene used as model compounds. Test results showed that the morphology and size of ZnO support has great influence on the desulfurization performance of the catalyst. Desulfurization catalyst prepared with nanowire-structured ZnO support has the best desulfurization performance, with its desulfurization rate reaching 98.2%. The result was achieved mainly due to the nanowire structure of ZnO support which could effectively restrain the agglomeration of metallic Ni on the surface and reduce the particle size of the active component of metallic Ni so as to improve its dispersion on the surface of the support. In addition, the nanowire structure can reduce the diffusion resistance of thiophene in the reaction process and provide a channel conducive to sulfur transfer and diffusion, which makes it perform well in the desulphurization reaction process and regeneration process. | Kang Lei Wang Haiyan Han Bing Li Shuanglin Sun Na Yang Zhanxu | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，2： | 3 |
| 16 | Injectable bioactive polymethyl methacrylate-hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty显示文摘Poly methyl methacrylate(PMMA)bone cement is used in augmenting and stabilizing fractured vertebral bodies through percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP).However,applications of PMMA bone cement are limited by the high elasticity modulus of PMMA,its low biodegradability,and its limited ability to regenerate bone.To improve PMMA bio activity and biodegradability and to modify its elasticity modulus,we mixed PMMA bone cement with oxidized hyaluronic acid and carboxymethyl chitosan in situ cross-linking hydrogel loaded with bone morphogenetic protein-2(BMP-2)to achieve novel hybrid cement.These fabric ated PMMA-hydrogel hybrid cements exhibited lower setting temperatures,a lower elasticity modulus,and better biodegradability and biocompatibility than that of pure PMMA cement,while retaining acceptable setting times,mechanical strength,and inj ectability.In addition,we detected release of BMP-2 from the PMMA-hydrogel hybrid cements,significantly enhancing in vitro osteogenesis of bone marrow mesenchymal stem cells by up-regulating the gene expression of Runx2,Coll,and OPN.Use of PMMA-hydrogel hybrid cements loaded with BMP-2 on rabbit femoral condyle bone-defect models revealed their biodegradability and enhanced bone formation.Our study demonstrated the favorable mechanical properties,biocompatibility,and biodegradability of fabricated PMMA-hydrogel hybrid cements loaded with BMP-2,as well as their ability to improve osteogenesis,making them a promising material for use in PKP and PVP. | Xin Sun Xin Zhang Xin Jiao Jie Ma Xingzhen Liu Han Yang Kangping Shen Yaokai Gan Jinwu Wang Haiyan Li Wenjie Jin | 2022 | Bio-Design and Manufacturing2022，5，2： | 3 |
| 17 | Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment显示文摘Breast cancer brain metastases(BCBMs)are one of the most difficult malignancies to treat due to the intracranial location and multifocal growth.Chemotherapy and molecular targeted therapy are extremely ineffective for BCBMs due to the inept brain accumulation because of the formidable bloodbrain barrier(BBB).Accumulation studies prove that low density lipoprotein receptor-related protein 1(LRP1)is promising target for BBB transcytosis.However,as the primary clearance receptor for amyloid beta and tissue plasminogen activator,LRP1 at abluminal side of BBB can clear LRP1-targeting therapeutics.Matrix metalloproteinase-1(MMP1)is highly enriched in metastatic niche to promote growth of BCBMs.Herein,it is reported that nanoparticles(NPs-K-s-A)tethered with MMP1-sensitive fusion peptide containing HER2-targeting K and LRP1-targeting angiopep-2(A),can surmount the BBB and escape LRP1-mediated clearance in metastatic niche.NPs-K-s-A revealed infinitely superior brain accumulation to angiopep-2-decorated NPs-A in BCBMs bearing mice,while comparable brain accumulation in normal mice.The delivered doxorubicin and lapatinib synergistically inhibit BCBMs growth and prolongs survival of mice bearing BCBMs.Due to the efficient BBB penetration,special and remarkable clearance escape,and facilitated therapeutic outcome,the fusion peptide-based drug delivery strategy may serve as a potential approach for clinical management of BCBMs. | Naveed Ullah Khan Jiang Ni Xiufeng Ju Tongtong Miao Haiyan Chen Liang Han | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 3 |
| 18 | Effects of Dietary Vitamins A,B_2,and B_6 Supplementation on Growth and Feed Utilization of Juvenile Chinese Soft-shelled Turtle Pelodiscus sinensis according to an Orthogonal Array Experiment显示文摘An orthogonal experimental design OA_9(3~3) was used to evaluate the effects of vitamins(A, B_2, and B_6) on the growth and digestive ability of the juvenile Chinese soft-shelled turtle, Pelodiscus sinensis(initial weight, 5.9±0.2 g). A total of 135 turtles were divided into 9 groups, which each included 15 individuals. The results revealed that vitamin A(VA) had the strongest impacts on the growth rate and feed utilization among the three vitamins; 35,000 IU kg^(-1) VA had optimal effects on the feeding intake and specific growth rate, and 20,000 IU kg^(-1) VA had optimal effects on protein digestibility and the feed conversion ratio. Vitamin B_2(VB_2) was essential for regulating protein deposition and the energy efficiency for growth of the turtles; 120 mg kg^(-1) VB_2 resulted in increased protein and energy deposition, and 180 mg kg^(-1) VB_2 had greater beneficial effects on the growth rate. Vitamin B_6(VB_6) had important effects on protein and feed efficiency; however, VB_6 at an excessive level(120 mg kg^(-1)) restricted turtle growth. Based on the above growth results, dietary supplementation of VA, VB_2 and VB_6 at levels of 35,000 IU kg^(-1), 180 mg kg^(-1) and 70 mg kg^(-1), respectively, were recommended for the juvenile soft-shelled turtle. | Junwei LI Zhencai YANG Xiaoling HAN Quansen XIE Haiyan LIU | 2016 | Asian Herpetological Research2016，7，4： | 2 |
| 19 | Automated rapid iterative negative geotaxis assay and its use in a genetic screen for modifi ers of Aβ_(42)-induced locomotor decline in Drosophila显示文摘The negative-geotaxis climbing assay is used to efficiently study aging and neurodegeneration in Drosophila.To make it suitable for large-scale study,a method called the rapid iterative negative geotaxis(RING) assay has been established by simultaneously photographing the climbing of multiple groups of flies when they are manually tapped down in test tubes.Here,we automated the assay by using a well-controlled electric motor to drive the tapping,and a homemade program to analyze the climbing height of flies.Using the automated RING(aRING) assay,we found that the climbing ability of a strain of wild-type flies,males in particular,declined rapidly before day 21 after eclosion,but slowly from day 21 to 35.We also found that the expression of arctic mutant Aβ_(42) accelerated the age-dependent decline in the climbing ability of flies.Moreover,using aRING,we examined the effect of third chromosome deficiencies on the accelerated locomotor decline in Aβ_(42)-expressing flies,and isolated 7 suppressors and15 enhancers. | Haiyan Liu Meng Han Qingyi Li Xiao Zhang Wen-An Wang Fu-De Huang | 2015 | Neuroscience Bulletin2015，31，5： | 2 |
| 20 | Analysis of the correlation between the longitudinal trajectory of SOFA scores and prognosis in patients with sepsis at 72 hour after admission based on group trajectory modeling显示文摘Background:To identify the distinct trajectories of the Sequential Organ Failure Assessment(SOFA)scores at 72 h for patients with sepsis in the Medical Information Mart for Intensive Care(MIMIC)-IV database and determine their effects on mortality and adverse clinical outcomes.Methods:A retrospective cohort study was carried out involving patients with sepsis from the MIMIC-IV database.Group-based trajectory modeling(GBTM)was used to identify the distinct trajectory groups for the SOFA scores in patients with sepsis in the intensive care unit(ICU).The Cox proportional hazards regression model was used to investigate the relationship between the longitudinal change trajectory of the SOFA score and mortality and adverse clinical outcomes.Results:A total of 16,743 patients with sepsis were included in the cohort.The median survival age was 66 years(interquartile range:54-76 years).The 7-day and 28-day in-hospital mortality were 6.0%and 17.6%,respectively.Five different trajectories of SOFA scores according to the model fitting standard were determined:group 1(32.8%),group 2(30.0%),group 3(17.6%),group 4(14.0%)and group 5(5.7%).Univariate and multivariate Cox regression analyses showed that,for different clinical outcomes,trajectory group 1 was used as the reference,while trajectory groups 2-5 were all risk factors associated with the outcome(P<0.001).Subgroup analysis revealed an interaction between the two covariates of age and mechanical ventilation and the different trajectory groups of patients’SOFA scores(P<0.05).Conclusion:This approach may help identify various groups of patients with sepsis,who may be at different levels of risk for adverse health outcomes,and provide subgroups with clinical importance. | Rui Yang Didi Han Luming Zhang Tao Huang Fengshuo Xu Shuai Zheng Haiyan Yin Jun Lyu | 2022 | Journal of Intensive Medicine2022，2，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员