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| 1 | Corrosion Resistance of Graphene-Reinforced Waterborne Epoxy Coatings显示文摘Graphene(G) was dispersed uniformly in water and used as an inhibitor in waterborne epoxy coatings.The effect of dispersed G on anticorrosion performance of epoxy coatings was evaluated.The composite coatings displayed outstanding barrier properties against H_2O molecule compared to the neat epoxy coating.Open circuit potential(OCP),Tafel and electrochemical impedance spectroscopy(EIS)analysis con-?rmed that the corrosion rate exhibited by composite coatings with 0.5 wt%G was an order of magnitude lower than that of neat epoxy coating.Salt spray test results revealed superior corrosion resistance offered by the composite coating. | Shuan Liu Lin Gu Haichao Zhao Jianmin Chen Haibin Yu | 2016 | Journal of Materials Science & Technology2016，32，5： | 67 |
| 2 | 乙型肝炎患者血清高迁移率族蛋白-1含量的检测及临床意义显示文摘目的观察不同病情的乙型肝炎患者血清中晚期炎症介质高迁移率族蛋白-1(HMGB1)的含量,通过与肝炎病情评价指标TBil和PTA进行相关性比对,初步阐明晚期炎症介质HMGB1在慢性重型乙型肝炎患者肝衰竭发生中可能发挥的作用。方法收集慢性重型乙型肝炎患者23例,CHB患者31例,健康对照者10名,抽取外周血10ml,按常规方法检测肝炎病情指标TBil和PTA。超滤管去除血清中的大分子蛋白质,再浓缩血清小分子蛋白,然后用Western blot的方法检测样品中HMGB1。利用纯化出的GST-HMGB1融合蛋白进行相对定量,计算出不同患者血清中HMGB1的水平,最后与肝炎病情评价指标TBil和PTA进行相关性比对。结果23例慢性重型乙型肝炎患者血清中HMGB1检出率为100%(23/23),平均含量为(83.4±21.3)μg/L;10例重度CHB患者血清中HMGB1检出率为90%(9/10),平均含量为(78.1±19.5)μg/L;11例中度CHB患者的血清中HMGB1检出率为55%(6/11),平均含量为(60.6±14.3)μg/L;10例轻度CHB患者及12例恢复患者中均仅1例检出HMGB1,检出率分别为10%和8%,含量分别为28.9μg/L和39.7μg/L;健康对照者血清中未能检出HMGB1。血清中HMGB1的含量与TBil呈正相关,与PTA呈负相关。结论慢性重型乙型肝炎患者血清中HMGB1的含量与疾病的严重程度密切相关,晚期炎症介质HMGB1在慢性重型乙型肝炎患者肝衰竭的发生中可能起重要的作用。 | 刘洪波 范学工 黄建军 李宁 彭建萍 李沙陵 Haichao Wang | 2007 | 中华肝脏病杂志2007，15，11： | 26 |
| 3 | Explicit diagnosis of the local ozone production rate and the ozone-NOx-VOC sensitivities显示文摘In the troposphere, ozone is a harmful gas compound to both human health and vegetation. Ozone is produced from the reaction of NO_x(@NO + NO_2) and VOCs(volatile organic compounds) with light. Due to the highly nonlinear relationships between ozone and its precursors, proper ozone mitigation relies on the knowledge of chemical mechanisms. In this study, an observation-based method is used to simulate ozone formation and elucidate its controlling factors for a rural site on the North China Plain. The instantaneous ozone production rate is calculated utilizing a box model using the dataset obtained from the Wangdu campaign. First, the model was operated in a time-dependent mode to calculate the ozone production rate at each time stamp. The calculated ozone formation rate showed a diurnal average maximum value of 17 ppbv/h(1-h diurnal averaged). The contribution of individual peroxy radicals to ozone production was analyzed. In addition, the functional dependence of calculated P(O_3) reveals that ozone production was in a NO_x-limited regime during the campaign. Furthermore, the missing peroxy radical source will further extend NO_x-limited conditions to earlier in the day, making NO_xlimitation dominate more of a day than the current chemical model predicts. Finally, a multiple scenarios mode,also known as EKMA(empirical kinetic modeling approach), was used to simulate the response of P(O_3) to the imaginary change in precursor concentrations. We found that ozone production was in the NO_x-limited region. However, the use of NO_2 measured by the molybdenum converter and/or the absence of a peroxy radical source in the current chemical model could over-emphasize the VOC-limited effect on ozone production. | Zhaofeng Tan Keding Lu Huabin Dong Min Hu Xin Li Yuhan Liu Sihua Lu Min Shao Rong Su Haichao Wang Yusheng Wu Andreas Wahner Yuanhang Zhang | 2018 | Science Bulletin2018，63，16： | 25 |
| 4 | Exploring atmospheric free-radical chemistry in China:the self-cleansing capacity and the formation of secondary air pollution显示文摘Since 1971,it has been known that the atmospheric free radicals play a pivotal role in maintaining the oxidizing power of the troposphere.The existence of the oxidizing power is an important feature of the troposphere to remove primary air pollutants emitted from human beings as well as those from the biosphere.Nevertheless,serious secondary air-pollution incidents can take place due to fast oxidation of the primary pollutants.Elucidating the atmospheric free-radical chemistry is a demanding task in the field of atmospheric chemistry worldwide,which includes two kinds of work:first,the setup of reliable radical detection systems;second,integrated field studies that enable closure studies on the sources and sinks of targeted radicals such as OH and NO3.In this review,we try to review the Chinese efforts to explore the atmospheric free-radical chemistry in such chemical complex environments and the possible link of this fast gas-phase oxidation with the fast formation of secondary air pollution in the city-cluster areas in China. | Keding Lu Song Guo Zhaofeng Tan Haichao Wang Dongjie Shang Yuhan Liu Xin Li Zhijun Wu Min Hu Yuanhang Zhang | 2019 | National Science Review2019，6，3： | 26 |
| 5 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 6 | Regulation of HMGB1 release by infl ammasomes显示文摘High mobility group box 1(HMGB1)is an evolutionarily conserved non-histone chromatin-binding protein.During infection or injury,activated immune cells and damaged cells release HMGB1 into the extracellular space,where HMGB1 functions as a proinflammatory mediator and contributes importantly to the pathogenesis of inflammatory diseases.Recent studies reveal that infl ammasomes,intracellular protein complexes,critically regulate HMGB1 release from activated immune cells in response to a variety of exogenous and endogenous danger signals.Double stranded RNA dependent kinase(PKR),an intracellular danger-sensing molecule,physically interacts with inflammasome components and is important for infl ammasome activation and HMGB1 release.Together,these studies not only unravel novel mechanisms of HMGB1 release during infl ammation,but also provide potential therapeutic targets to treat HMGB1-related infl ammatory diseases. | Ben Lu Haichao Wang Ulf Andersson Kevin J.Tracey | 2013 | Protein & Cell2013，4，3： | 21 |
| 7 | Network-Connected UAV Communications: Potentials and Challenges显示文摘This article explores the use of network-connected unmanned aerial vehicle(UAV) communications as a compelling solution to achieve high-rate information transmission and support ultra-reliable UAV remote command and control. We first discuss the use cases of UAVs and the resulting communication requirements, accompanied with a flexible architecture for network-connected UAV communications. Then, the signal transmission and interference characteristics are theoretically analyzed, and subsequently we highlight the design and optimization considerations, including antenna design, nonorthogonal multiple access communications, as well as network selection and association optimization. Finally, case studies are provided to show the feasibility of network-connected UAV communications. | Haichao Wang Jinlong Wang Jin Chen Yuping Gong Guoru Ding | 2018 | China Communications2018，15，12： | 14 |
| 8 | HMGB1对人肝癌细胞株HepG2体外增殖的影响显示文摘目的:观察HMGB1对人肝癌细胞株HepG2增殖的影响并初步探讨其可能机制。方法:采用不同剂量(0,10,50,100 ng/mL)重组HMGB1(rHMGB1)刺激HepG2细胞24 h,用MTT法检测HepG2细胞增殖,Western印迹和RT-PCR法检测cyclin D1,PCNA的表达。结果:不同剂量(10,50,100 ng/mL)rHMGB1组HepG2细胞增殖能力均明显高于对照组(P<0.05)。HMGB1抗体(20μg/mL)能中和HMGB1(10ng/mL)对HepG2细胞的促增殖作用(P<0.05)。Western印迹和RT-PCR显示,与对照组比较,HMGB1能明显促进HepG2细胞PCNA,cyclin Dl蛋白和mRNA的表达(P<0.05),HMGB1抗体能明显抑制HMGB1上调PCNA,cyclin Dl蛋白和mRNA的表达(P<0.05)。结论:HMGB1可能通过上调cyc-lin Dl和PCNA表达,促进HepG2细胞增殖。HMGB1抗体对肝细胞癌可能有治疗作用。 | 贺新春 范学工 周蓉蓉 WANG Haichao | 2010 | 中南大学学报(医学版)2010，35，5： | 13 |
| 9 | HF Communications: Past, Present, and Future显示文摘High frequency(HF) communication, commonly covering frequency range between 3 and 30 MHz, is an important wireless communication paradigm to offer over-thehorizon or even global communications with ranges up to thousands of kilometers via skywave propagation with ionospheric refraction. It has widespread applications in fields such as emergency communications in disaster areas, remote communications with aircrafts or ships and non-light-of-the-sight military operations. This tutorial article overviews the history of HF communication, demystifies the recent advances, and provides a preview of the next few years, which the authors believe will see fruitful outputs towards wideband, intelligent and integrated HF communications. Specifically, we first present brief preliminaries on the unique features of HF communications to facilitate general readers in the communication community. Then, we provide a historical review to show the technical evolution on the three generations of HF communication systems. Further, we highlight the key challenges and research directions. We hope that this article will stimulate more interests in addressing the technical challenges on the research and development of future HF radio communication systems. | Jinlong Wang Guoru Ding Haichao Wang | 2018 | China Communications2018，15，9： | 12 |
| 10 | Multi-Objective Optimization of Surface-Mounted and Interior Permanent Magnet Synchronous Motor Based on Taguchi Method and Response Surface Method显示文摘The surface-mounted and interior permanent magnet synchronous motor(SIPMSM)has the characteristics of multiple variables,strong coupling and nonlinearity.In order to improve the performance of SIPMSM,this paper presents a multi-objective optimal design process using Taguchi and response surface methodology(RSM).The peak value of cogging torque(PVCT),ratio value of average torque and permanent magnet weight(RTW),torque ripple and back-EMF total harmonics distortion(ETHD)are selected as optimization goals.The experiment matrix is established by Taguchi method,and analyzed the tendency and proportion of the effect of the optimization parameters on SIPMSM performance.The rules of choosing multi-objective optimization parameters are obtained.The least-squares method is used to establish the optimal objective function,and RSM is used to obtain the resolutions of the optimization objective function.Comparing the initial performance with optimized performance verifies the effectiveness of the proposed method. | Jikai Si Suzhen Zhao Haichao Feng Ruiwu Cao Yihua Hu | 2018 | Chinese Journal of Electrical Engineering2018，4，1： | 11 |
| 11 | Effects of weaning age on growth, nutrient digestibility and metabolism,and serum parameters in Hu lambs显示文摘This study was conducted to investigate the effect of weaning age on growth performance, nutrient digestion and metabolism, and serological indicators, and to obtain an optimal weaning age in Hu lambs.Forty-eight newborn Hu lambs(birth weight, 2.53 ± 0.14 kg) were randomly divided into 4 groups. The lambs in control group(ER) suckled their dams. The lambs in other three experimental groups were weaned on milk replacer at 10.20, and 30 days of age(EW10, EW20, and EW30 groups),respectively. The results were as follows: 1) lambs in EW10 and EW30 groups had a lower(P < 0.05) ADG than those in ER group within 10 days post-weaning; the weaned lambs began to show a higher(P < 0.05) ADG than those in ER group after 20 days post-weaning. 2) EW10 and EW20 groups had a higher(P < 0.05) creep feed intake than EW30 and ER groups from 15 to 60 days of age. 3) The apparent digestibility of dry matter, organic matter, gross energy, nitrogen, ether extract and phosphorus, and the deposition of nitrogen and phosphorus did not differ(P > 0.05) among groups; however, the apparent digestibility and deposition of calcium in early weaned lambs were lower(P < 0.05) than those in ewe-reared lambs. 4)The albumin content in EW30 group was lower(P < 0.05) than that in ER group; the globulin content in EW30 group was higher(P < 0.05) than that in other groups; the content of serum insulin-like growth factor-1 in weaned lambs tended to increase compared with lambs in ER group. Finally, the growth rate of lambs decreased within 10 days post-weaning, but early weaning boosted creep feed intake, leading to better growth and health later in life. The Hu lambs can be weaned on milk replacer and creep feed at 10 days of age. | Jianmin Chai Qiyu Diao Haichao Wang Yan Tu Xiaojing Tao Naifeng Zhang | 2015 | Animal Nutrition2015，，4： | 10 |
| 12 | Defect-rich MoS2 nanowall catalyst for efficient hydrogen evolution reaction显示文摘为氢进化反应设计有效 electrocatalysts (她的) 由于对干净精力的迫切要求吸引了实质的注意在不久的将来面对精力危机和随后的环境问题。在她的催化剂的大变化之中,铝二硫化物(瞬间 2) 由于它的丰富,低价格,高效率,和明确的催化机制被认为是最著名的催化剂。在这研究,有可控制的厚度的设计缺点的瞬间 2 nanowall (NW ) 催化剂被制作并且展出一显著地提高了她的表演。得益于高度暴露的活跃的边地点和不平的表面由柔韧的 NW 结构伴随了,有优化厚度的充满缺点的瞬间 2 NW 催化剂显示出 85 mV 的 ultralow 发作过电位, 310.6 | Junfeng Xie Haichao Qu Jianping Xin Xinxia Zhang Guanwei Cui Xiaodong Zhang Jian Bao Bo Tang Yi Xie | 2017 | Nano Research2017，10，4： | 8 |
| 13 | Efficient aerobic oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid on Ru/C catalysts显示文摘2,5-Furandicarboxylic(FDCA) is a potential substitute for petroleum-derived terephthalic acid, and aerobic oxidation of5-hydroxymethylfurfural(HMF) provides an efficient route to synthesis of FDCA. On an activated carbon supported ruthenium(Ru/C) catalyst(with 5 wt% Ru loading), HMF was readily oxidized to FDCA in a high yield of 97.3% at 383 K and 1.0 MPa O_2 in the presence of Mg(OH)_2 as base additive. Ru/C was superior to Pt/C and Pd/C and also other supported Ru catalysts with similar sizes of metal nanoparticles(1–2 nm). The Ru/C catalysts were stable and recyclable, and their efficiency in the formation of FDCA increased with Ru loadings examined in the range of 0.5 wt%–5.0 wt%. Based on the kinetic studies including the effects of reaction time, reaction temperature, O_2 pressure, on the oxidation of HMF to FDCA on Ru/C, it was confirmed that the oxidation of HMF to FDCA proceeds involving the primary oxidation of HMF to 2,5-diformylfuran(DFF) intermediate, and its sequential oxidation to 5-formyl-2-furancarboxylic acid(FFCA) and ultimately to FDCA, in which the oxidation of FFCA to FDCA is the rate-determining step and dictates the overall formation rate of FDCA. This study provides directions towards efficient synthesis of FDCA from HMF, for example, by designing novel catalysts more efficient for the involved oxidation step of FFCA to FDCA. | Lufan Zheng Junqi Zhao Zexue Du Baoning Zong Haichao Liu | 2017 | Science China Chemistry2017，60，7： | 8 |
| 14 | Cellulose conversion to polyols on supported Ru catalysts in aqueous basic solution显示文摘It is of great significance and challenge to achieve direct conversion of cellulose to specific polyols,e.g.,ethylene glycol and propylene glycol.For such selective conversion,a novel one-pot approach was studied by combination of alkaline hydrolysis and hydrogenation on supported Ru catalysts.A wide range of bases including solid bases,e.g.,Ca(OH)2 and La2O3,and phosphate buffers were examined in the cellulose reaction in water,and the cellulose conversions and polyol products depended largely on the basicity or pH values in the aqueous solutions.Ethylene glycol,1,2-propanediol,and especially 1,2,5-pentanetriol were obtained with selectivities of 15%,14% and 22%,respectively,at 38% cellulose conversion at pH 8 in phosphate buffer solution.These preliminary results provide potentials for efficient conversion of cellulose to targeted polyols by using the advantages of bases. | DENG TianYin,SUN JiYing & LIU HaiChao Beijing National Laboratory for Molecular Sciences,State Key Laboratory for Structural Chemistry of Stable and Unstable Species Green Chemistry Center,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China | 2010 | Science China Chemistry2010，53，7： | 8 |
| 15 | Betaine affects muscle lipid metabolism via regulating the fatty acid uptake and oxidation in finishing pig显示文摘Background: Betaine affects fat metabolism in animals, but the specific mechanism is still not clear. The purpose of this study was to investigate possible mechanisms of betaine in altering lipid metabolism in muscle tissue in finishing pigs.Methods: A total of 120 crossbred gilts(Landrace × Yorkshire × Duroc) with an average initial body weight of 70.1 kg were randomly allotted to three dietary treatments. The treatments included a corn–soybean meal basal diet supplemented with 0, 1250 or 2500 mg/kg betaine. The feeding experiment lasted 42 d.Results: Betaine addition to the diet significantly increased the concentration of free fatty acids(FFA) in muscle(P < 0.05). Furthermore, the levels of serum cholesterol and high-density lipoprotein cholesterol were decreased(P < 0.05) and total cholesterol content was increased in muscle(P < 0.05) of betaine fed pigs. Experiments on genes involved in fatty acid transport showed that betaine increased expression of lipoprotein lipase(LPL), fatty acid translocase/cluster of differentiation(FAT/CD36), fatty acid binding protein(FABP3) and fatty acid transport protein(FATP1)(P < 0.05). The abundance of fatty acid transport protein and fatty acid binding protein were also increased by betaine(P < 0.05). As for the key factors involved in fatty acid oxidation, although betaine supplementation didn't affect the level of carnitine and malonyl-CoA, betaine increased mR NA and protein abundance of carnitine palmitransferase-1(CPT1)and phosphorylated-AMPK(P < 0.05).Conclusions: The results suggested that betaine may promoted muscle fatty acid uptake via up-regulating the genes related to fatty acid transporter including FAT/CD36, FATP1 and FABP3. On the other hand, betaine activated AMPK and up-regulated genes related to fatty acid oxidation including PPARα and CPT1. The underlying mechanism regulating fatty acid metabolism in pigs supplemented with betaine is associated with the up-regulation of genes involved in fatty acid transport and fatty acid oxidation. | Sisi Li Haichao Wang Xinxia Wang Yizhen Wang Jie Feng | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 8 |
| 16 | Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period显示文摘Background:Early pregnancy failure has a profound impact on both human reproductive health and animal production.2/3 pregnancy failures occur during the peri-implantation period;however,the underlying mechanism(s)remains unclear.Well-organized modification of the endometrium to a receptive state is critical to establish pregnancy.Aberrant endometrial modification during implantation is thought to be largely responsible for early pregnancy loss.Result:In this study,using well-managed recipient ewes that received embryo transfer as model,we compared the endometrial proteome between pregnant and non-pregnant ewes during implantation period.After embryo transfer,recipients were assigned as pregnant or non-pregnant ewes according to the presence or absence of an elongated conceptus at Day 17 of pregnancy.By comparing the endometrial proteomic profiles between pregnant and non-pregnant ewes,we identified 94 and 257 differentially expressed proteins(DEPs) in the endometrial caruncular and intercaruncular areas,respectively.Functional analysis showed that the DEPs were mainly associated with immune response,nutrient transport and utilization,as well as proteasome-mediated proteolysis.Conclusion:These analysis imply that dysfunction of these biological processes or pathways of DEP in the endometrium is highly associated with early pregnancy loss.In addition,many proteins that are essential for the establishment of pregnancy showed dysregulation in the endometrium of non-pregnant ewes.These proteins,as potential candidates,may contribute to early pregnancy loss. | Haichao Zhao Linlin Sui Kai Miao Lei An Dong Wang Zhuocheng Hou Rui Wang Min Guo Zhilong Wang Jiqiang Xu Zhonghong Wu Jianhui Tian | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 8 |
| 17 | Proactive optimization of transmission power and 3D trajectory in UAV-assisted relay systems with mobile ground users显示文摘In this paper,an Unmanned Aerial Vehicle(UAV)-assisted relay communication system is studied,where a UAV is served as a flying relay to maintain a communication link between a mobile source node and a remote destination node.Specifically,an average outage probability minimization problem is formulated firstly,with the constraints on the transmission power of the source node,the maximum energy consumption budget,the transmission power,the speed and acceleration of the flying UAV relay.Next,the closed-form of outage probability is derived,under the hybrid line-of-sight and non-line-of-sight probability channel model.To deal with the formulated nonconvex optimization,a long-term proactive optimization mechanism is developed.In particular,firstly,an approximation for line-of-sight probability and a reformulation of the primal problem are given,respectively.Then,the reformulated problem is transformed into two subproblems:one is the transmission power optimization with given UAV’s trajectory and the other is the trajectory optimization with given transmission power allocation.Next,two subproblems are tackled via tailoring primal–dual subgradient method and successive convex approximation,respectively.Furthermore,a proactive optimization algorithm is proposed to jointly optimize the transmission power allocation and the three-dimensional trajectory.Finally,simulation results demonstrate the performance of the proposed algorithm under various parameter configurations. | Jiangchun GU Guoru DING Yitao XU Haichao WANG Qihui WU | 2021 | Chinese Journal of Aeronautics2021，34，3： | 7 |
| 18 | Influence of C/Ti stoichiometry in TiC_x on the grain refinement efficiency of Al–Ti–C master alloy显示文摘TiC_x contained Al–Ti–C is a kind of grain refiner for Al alloys. In this work, the influence of C/Ti stoichiometry, i.e. the x value in TiC_x on grain refinement efficiency was investigated. TiC_x particles have been obtained in five Al–5Ti–m C(m = 0.1, 0.5, 0.8, 1, 1.25) master alloys and the x values were measured to be0.72, 0.75, 0.79, 0.81 and 0.8, respectively. It was found that the refinement performance of the master alloys had a close relationship with the x value of TiC_x . The Al–5Ti–m C alloy with lower-x TiC_x shows better refinement efficiency and anti-fading capability. It is supposed that TiC_x particles with lower x are more preferred to release Ti atoms during nucleating process and have a better Ti-absorbing capability.This contributes to the Ti-rich zone formation at TiC_x /melt interface, thus enhancing the refinement and anti-fading capability. | Huabing Yang Tong Gao Haichao Wang Jinfeng Nie Xiangfa Liu | 2017 | Journal of Materials Science & Technology2017，33，7： | 6 |
| 19 | Association of a missense mutation in the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) with superovulation traits in Chinese Holstein heifers显示文摘Background: Upon binding luteinizing hormone in the ovary, the luteinizing hormone/choriogonadotropin receptor (LHCGR) is necessary for follicular maturation and ovulation, as well as luteal function. We detected mutations in the LHCGR gene and evaluated their association with superovulation. Methods: Using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing, we examined polymorphisms in LHCGR and the genotypes associated with superovulation traits in 127 Chinese Holstein heifers. Results: A G/T polymorphism (ss52050737) in exon 11 was significantly associated with the total number of ova and the number of transferable embryos. Conclusions: LHCGR may be a new predictor for superovulation in Chinese Holstein heifers. | Yong Yu Yunwei Pang Haichao Zhao Xiaoling Xu Zhonghong Wu Lei An Jianhui Tian | 2012 | Journal of Animal Science and Biotechnology2012，3，4： | 6 |
| 20 | 人HMGB1基因的克隆、融合表达与生物学活性显示文摘采用RT-PCR,从重症肝炎病人外周血单个核细胞(peripheral blood mononuclear cellsPBMCs)的mRNA中扩增高迁移率族蛋白1(high mobility group box-1protein,HMGB1)基因,构建重组表达质粒pGEX4T-1-HMGB1,转化入大肠杆菌,测序证实其序列与基因数据库中HMGB1基因(NM_002128)一致。诱导表达的融合蛋白GST-HMGB1,用Glutathione Sepharose4B亲和层析纯化,经Thrombin酶切得到HMGB1。结果显示:经Western-blotting检测,GST-HMGB1和HMGB1均具有免疫活性;ELISA和MTT检测发现,两者均能刺激RAW264.7细胞产生大量TNF-α,明显刺激HeLa细胞增殖。GST-HMGB1具有良好的生物学活性,为今后的研究打下了基础。 | 刘洪波 范学工 Haichao Wang 彭建萍 黄建军 李宁 | 2006 | 中国生物工程杂志2006，26，11： | 6 |
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