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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | 基于NMR的代谢组学方法最新进展及应用(英文)显示文摘代谢组学的定义“对病理/生理刺激以及基因改变时生物体系动态的代谢响应进行多参数的定量测量”已被广泛接受.本文对代谢组学研究的最新进展及其在系统生物学中所发挥的作用进行了综述.在代谢组学方法研究方面,着重讨论了现代NMR技术的进展及其对代谢组学所产生的影响,同时也包括用于分离的HPLC及其与质谱的连用技术.对代谢组学广泛应用的概述,主要包括:对正常生理变化的新认识;药物和其他外源性化学物质的副作用;外源性物质对环境污染的影响以及逐渐增多的代谢组学方法在疾病检测中应用. | LINDON J C HOLMES E NICHOLSON J K | 2006 | 波谱学杂志2006，23，1： | 10 |
| 3 | Systematic review of the prevalence and development of osteoporosis or low bone mineral density and its risk factors in patients with inflammatory bowel disease显示文摘BACKGROUND The inflammatory bowel diseases(IBD),Crohn’s disease(CD)and ulcerative colitis(UC)are chronic,immune-mediated disorders of the digestive tract.IBD is considered to be a risk factor for developing osteoporosis;however current literature on this matter is inconsistent.AIM To assess prevalence and development of osteoporosis and low bone mineral density(BMD),and its risk factors,in IBD patients.METHODS Systematic review of population-based studies.Studies were identified by electronic(January 2018)and manual searches(May 2018).Databases searched included EMBASE and PubMed and abstracts from 2014-2018 presented at the United European Gastroenterology Week,the European Crohn’s and Colitis Organisation congress,and Digestive Disease Week were screened.Studies were eligible for inclusion if they investigated either the prevalence of osteoporosis or osteopenia and/or risk factors for osteoporosis or low BMD in IBD patients.Studies on children under the age of 18 were excluded.Only population-based studies were included.All risk factors for osteoporosis and low BMD investigated in any included article were considered.Study quality and the possibility of bias were analysed using the Newcastle-Ottawa scale.RESULTS Twelve studies including 3661 IBD patients and 12789 healthy controls were included.Prevalence of osteoporosis varied between 4%-9%in studies including both CD and UC patients;2%-9% in studies including UC patients, and 7%-15% instudies including CD patients. Among healthy controls, prevalence ofosteoporosis was 3% and 10% in two studies. CD diagnosis, lower body massindex (BMI), and lower body weight were risk factors associated withosteoporosis or low BMD. Findings regarding gender showed inconsistent results.CD patients had an increased risk for osteoporosis or low BMD over time, whileUC patients did not. Increased age was associated with decreased BMD, and therewas a positive association between weight and BMI and BMD over time. Greatheterogeneity was found in the included studies in terms of study methodologies,definitions and the assessment of osteoporosis, and only a small number ofpopulation-based studies was available.CONCLUSIONThis systematic review found a possible increase of prevalence of osteoporosis inCD cohorts when compared to UC and cohorts including both disease types.Lower weight and lower BMI were predictors of osteoporosis or low BMD in IBDpatients. The results varied considerably between studies. | Sofia Kärnsund Bobby Lo Flemming Bendtsen Jakob Holm Johan Burisch | 2020 | World Journal of Gastroenterology2020，26，35： | 8 |
| 4 | Clinical Presentation, Investigation, and Management of Pulmonary Vein Stenosis Complicating Ablation for Atrial Fibrillation显示文摘 | Douglas L. Packer Paul Keelan Thomas M. Munger Jerome F. Breen Sam Asirvatham Laura A. Peterson Kristi H. Monahan Mary F. Hauser K Chandrasekaran Lawrence J. Sinak David R. Holmes | 2005 | Circulation2005，，5： | 2 |
| 5 | Aspects of modeling of high voltage ferroelectric nonlinear ceramic capacitors 显示文摘 | CAMPBELL C K VANWYK J D HOLM M F K | 1992 | IEEE Trans Compon Hydirds Manuf Technol1992，15，2： | 2 |
| 6 | Relaxation effects in high-voltage barium titanate non-linear ceramic disk capacitors 显示文摘 | CAMPBELL C K VANWYK J D HOLM M F K | 1993 | IEEE Trans Compon Hydirds Manuf Technol1993，16，4： | 2 |
| 7 | Double-level cauda equina compression: an experimental study with continuous monitoring of intraneural blood flow in the porcine cauda equina显示文摘 | Takahashi K Olmarker K Holm S | 1993 | J Orthop Res1993，11，1： | 1 |
| 8 | Creating value through mutual commitment to business network relationships 显示文摘 | HOLM D B K ERIKSSON J JOHANSON | 1999 | Strategic Management J1999，20，： | 1 |
| 9 | Thermophily in the Geobacteraceae: Geotherrnobacter ehrlichii gen nov, sp nov, a novel thermophilic member of the Geobacteraceae from the 'Bag City' hydrothermal vent显示文摘 | Kashefi K Holmes D E Baross J A | 2003 | Applied and Environmental Microbiology2003，69，： | 1 |
| 10 | APOBEC-mediated viral restriction: not simply editing? 显示文摘 | Holmes R K Malim M H Bishop K N | 2007 | Trends Biochem Sci2007，32，3： | 1 |
| 11 | In vitro replication of mouse hepatitis virus strain A59显示文摘 | Compton J R Rogers D B Holmes K V | 1987 | J Virol1987，61，： | 1 |
| 12 | ChitosanN-sulfate,A watersoluble polyelectrolyte 显示文摘 | Holme K R Perlin A | 1997 | Carbohydrate Research1997，302，： | 1 |
| 13 | Passivity-Based Control of Bipedal Locomotion 显示文摘 | Spong M W Holm J K Dongjun Lee | 2007 | IEEE Robotics & Automation Magazine (S1070-9932)2007，14，30： | 1 |
| 14 | Design and selection of spray/mist elimination equipment 显示文摘 | HOLMES T L CHEN G K | 1984 | Chem Eng1984，91，21： | 1 |
| 15 | Toxicological applications of magnetic resonance显示文摘 | LINDON J C HOLMES E NICHOLSON J K | | 0，，： | 1 |
| 16 | Safety of percutaneous left atrial appendage closure: results from the Watchman Left Atrial Appendage System for Embolic Protection in Patients with AF (PROTECT AF) clinical trial and the Continued Access Registry 显示文摘 | REDDY V Y HOLMES D DOSHI S K | 2011 | Circulation2011，123，： | 1 |
| 17 | Planning to Teach with Digital Tools: Introducing the Interactive Whiteboard to Pre-Service Secondary Mathematics Teachers显示文摘 | Holmes K | 2009 | Australasian Journal of Educational Technology2009，25，3： | 1 |
| 18 | SARS-associated coronavirus显示文摘 | Holmes K | 2003 | N ENGL J MED2003，348，20： | 1 |
| 19 | Isolation of coronavirus envelope glycoproteins and interaction with the viral nucleocapsid 显示文摘 | Sturman L S Holmes K V Behnke J | 1980 | J Virol1980，33，： | 1 |
| 20 | Changing trends in non-melanoma skin cancer in South Wales,1988-1998显示文摘 | Holmes SA Malinovszky K Roberts DL | 2000 | Br J Dermatol2000，143，： | 1 |
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