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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | On Linear Operators Having Supercyclic Vectors 显示文摘 | Herzog G | 1992 | Stuid Math1992，103，3： | 1 |
| 3 | Depression, Anx- iety, and Somatoform Disorders: Vague or Distinct Categories in Primary Care? Results from a Large Cross-sectional Study 显示文摘 | Hanel G Henningsen P Herzog W | 2009 | J Psychosom Res2009，67，3： | 1 |
| 4 | Effects of topographic variability on the scaling of plant species richness in gradient dominated landscapes 显示文摘 | Hofer G Wagner H H Herzog F Edwards PJ | 2008 | Ecography2008，31，： | 1 |
| 5 | Frequency ofcatamenial seizure exacerbation in women with localization-re-lated epilepsy显示文摘 | Herzog A G Harden C L Liporace J | 2004 | Ann Neurol2004，56，3： | 1 |
| 6 | Progress in CT imaging for the cardiac surgeon显示文摘 | Herzog C Wimmer Greinecker G Schwarz W | 2004 | Semin Thorac Cardiovasc Surg2004，16，3： | 1 |
| 7 | ADAMTS13 autoantibodies in patients with thrombotic microangiopathies and other immunomedi- ated diseases显示文摘 | Rieger M Mannucci PM Kremer Hovinga JA Herzog A Ger- stenbauer G Konetschny C | 2005 | Blood2005，106，4： | 1 |
| 8 | The benefits of maximum efficiency hydraulic fluids显示文摘 | HERZOG S N NEVEU C D PLACEK D G | 2005 | Machinery Lubrication2005，7，： | 1 |
| 9 | Field evaluation of fourteen soybean genotypes for resistance to Whitefly( Homoptera: Aleyrodidae) infestations 显示文摘 | Lambert A L Mepherson R M Herzog G A | 1997 | Journal of Economic Entomology1997，90，2： | 1 |
| 10 | Recurrent antecedent hypoglycemia alters neuronal oxidative metabolism in vivo显示文摘 | Jiang L Herzog R I Mason G F | 2009 | Diabetes2009，58，6： | 1 |
| 11 | Determination of trace metals by underpotential deposition-stripping voltammetry at solid electrodes显示文摘 | Herzog G Arrigan D W M | 2005 | Trends Anal Chem2005，24，3： | 1 |
| 12 | Frustrated Two - photon Creation via Interference 显示文摘 | HERZOG T J RARITY J G WEINFURTER H | 1994 | Phys Rev Lett1994，72，： | 1 |
| 13 | Field evaluation of fourteen soybean genotype for resistance to whitefly (Homoptera: Aleyrodidae) infestation显示文摘 | LAMBERT A L MCPHERSON R M HERZOG G A | 1997 | J Econ Entomol1997，90，2： | 1 |
| 14 | The interaction of Neu- ropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF显示文摘 | Neufeld G Kessler O Herzog Y | 2002 | Adv Exp Med Biol2002，515，： | 1 |
| 15 | Acute myocardial in-farction and renal dysfunction:a high-risk combination显示文摘 | Wright R S Reeder G S Herzog C A | 2002 | AnnIntern Med2002，137，7： | 1 |
| 16 | Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes显示文摘 | Kleiner- Fisman G Herzog J Fisman DN | 2006 | Mov Disord2006，2114，： | 1 |
| 17 | Isotopic co-mposition of zinc,copper,and iron in lunar samples显示文摘 | Moynier F Albarede F Herzog G F | 2006 | Geochim Cosmochim Acta2006，70，： | 1 |
| 18 | Analytical Color Gamut Representations 显示文摘 | HERZOG P G | 1996 | Journal of Imaging Science and Technology1996，40，6： | 1 |
| 19 | Isotopic and elemental abundances of copper and zinc in lunar samples,Zagami,Pelé's hairs,and a terrestrial basalt显示文摘 | Herzog G F Moynier F Albarède F | 2009 | Geochimica et Cosmochimica Acta2009，73，19： | 1 |
| 20 | Multi-detector CT: head and neck imaging 显示文摘 | MACK M G BALZER J O HERZOG C | 2003 | Eur Radiol2003，13，5： | 1 |
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