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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 3 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 4 | 激活β_3肾上腺素能受体恢复一氧化氮/氧化还原平衡,增强高血糖患者的内皮功能显示文摘一氧化氮与O_2^-之间的平衡紊乱(即一氧化氮/氧化还原失衡)是糖尿病引起的血管功能障碍的中心病理环节。该研究目的为在高血糖动物模型中探索β_3肾上腺素能受体(β_3adrenergic receptor,β3AR)激活能否耦合激活内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)。 | 刘莉 叶鹏 Karimi Galougahi K Liu CC Garcia A Gentile C Fry NA Hamilton EJ Hawkins CL Figtree GA | 2016 | 中华高血压杂志2016，24，3： | 2 |
| 5 | Influence of temperature and vegetation cover on soluble inorganic and organic nitrogen in a spodosol显示文摘 | P.J Chapman B.L Williams A Hawkins | 2001 | Soil Biology and Biochemistry2001，，7： | 2 |
| 6 | Paper birch and lodgepole pine root reinforcement in coarse-, medium-, and fine-,textured soils显示文摘 | Campbell K A Hawkins C D B | 2003 | Canadian Journal of Forest Research2003，33，： | 1 |
| 7 | Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression显示文摘 | DRAKE J A HAWKINS K A | 2004 | Breast Cancer Res2004，6，5： | 1 |
| 8 | Relationship between earthquake disturbance, tropical rainstorms and debris movement: An overview from Taiwan显示文摘 | Chen H Hawkins A B | 2009 | Bulletin of Engineering Geology and the Environment2009，68，： | 1 |
| 9 | Consumer Digital Radio: from Concept to Reality 显示文摘 | Tuttlebee W H W Hawkins D A | 1998 | Electronics & Communication Engineering Journal1998，10，6： | 1 |
| 10 | Mariana Trough basalts (MTB):Trace element and Sr-Nd isotopic evidence for mixing between MORB-like and arc-like melts显示文摘 | VOLPE A M MACDOUGALL J D HAWKINS J W | 1987 | Earth and Planetary Science Letters1987，82，： | 1 |
| 11 | Shear transfer in rein- forced concrete-recent research 显示文摘 | Mattock A H Hawkins N M | 1972 | 17 (2) : 55 -751972，17，2： | 1 |
| 12 | Glutamate perme-ability at the blood-brain barrier in insulinopenic and insulin-resistant rats显示文摘 | Hawkins RA Mokashi A Dejoseph MR | | 0，，02： | 1 |
| 13 | Sensitivity of sandstone strength and eformability to changes in moisture content显示文摘 | Hawkins A B Mcconnell B J | 1992 | Engineering geology1992，25，2： | 1 |
| 14 | Recent advances in aqueous two-component systems for heavy-duty metal protection显示文摘 | C A HAWKINS A C SHEPPARD T G WOOD | 1997 | Progress in Organic Coatings1997，，32： | 1 |
| 15 | Influence of material and geometry variations on the behaviour of bonded tee connections in FRP ships 显示文摘 | ShenoiR A Hawkins G L | 1992 | Composites1992，23，5： | 1 |
| 16 | Carcass composting for managing farm mortali- ties :a review显示文摘 | Kalbasi A Mukhtar S Hawkins S E | 2005 | Compost Science & Utiliza- tion2005，13，： | 1 |
| 17 | Remission of type 2 diabetes after gastric bypass and banding: mechanisms and two year outcomes 显示文摘 | Pournaras DJ Osborne A Hawkins SC | 2010 | Ann Surg2010，252，： | 1 |
| 18 | Phylogenetic determination of the pace of transposable element proliferation in plants: copia and LINE-like elements in Gossypium显示文摘 | Hawkins J S Hu G Rapp R A | 2007 | Genome2007，51，1： | 1 |
| 19 | Sensitivity of sandstone strength and deformability to changes in moisture content 显示文摘 | HAWKINS A B MCCONNELL B J | 1992 | Quarterly Journal of Engineering Geology and Hydrogeology1992，25，2： | 1 |
| 20 | Growth and feeding of juvenile cod, Gadus morhua L显示文摘 | Hawkins A D Soofiani N M Smith G W | 1985 | J Cons Penn Int Explor Mer1985，42，： | 1 |
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