|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 3 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 4 | Characterization of flavonoids in cranberry (Vaccinium macrocarpon) powder显示文摘 | VVEDENSKAYA I O ROSEN R T GUIDO J E RUSSELL D J MILLS K A VORSA N | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 5 | A distributed operating system for the 1990s显示文摘 | Sape J M Guido V R Andrew S T | 1990 | IEEE Computer1990，23，5： | 1 |
| 6 | Serum levels of eosinophile cationic protein in allergic disease sand natural allergen exposure显示文摘 | Margherila T Laura M Guido DP | 1996 | J Allergy Clin Immunol1996，97，6： | 1 |
| 7 | Damage Detection of a Prestressed Concrete Beam Using Modal Strains 显示文摘 | Jtirg F U Anne T Guido D R | 2005 | Journal of Structural Engineering2005，131，9： | 1 |
| 8 | Impact of a self-expanding, plastic esophageal stent on various esophageal stenoses, fistulas, and leakages: a single-center experience in 39 patients显示文摘 | Klaus R Guido G Ulrich T | 2005 | Gastrointest Endosc2005，61，7： | 1 |
| 9 | Politcal and monetary institutions and public finance policies in the industrial counutries显示文摘 | Grilli V Donato M A Guido T A | 1991 | Economic Policy1991，，13： | 1 |
| 10 | Serum levels of eosinophil cationic protein in allergic diseases and natural allergen exposure 显示文摘 | Marghefila T Laura M Guido DP | 1996 | J Allergy Clin Immunol1996，97，6： | 1 |
| 11 | Tyrosine Kinase Inhibitors:From Rational Design to Clinical Trials显示文摘 | Perter T Guido B Elisabeth B | 2001 | Med Res Rev2001，21，6： | 1 |
| 12 | SJES14110700138146显示文摘 | Michael Manns Stanislas Pol Ira M Jacobson Patrick Marcellin Stuart C Gordon Cheng-Yuan Peng Ting-Tsung Chang Gregory T Everson Jeong Heo Guido Gerken Boris Yoffe William J Towner Marc Bourliere Sophie Metivier Chi-Jen Chu William Sievert Jean-Pierre Bron | 2014 | The Lancet2014，，9954： | 1 |
| 13 | Adsorption of Trichoderma reesei CBH Ⅰ and EG Ⅱ and their catalytic domains on steam pretreated softwood and isolated lignin 显示文摘 | HETTI P FOLKE T GUIDO Z | 2004 | Biotechnology2004，107，1： | 1 |
| 14 | Heparan sulfate proteoglyean expression in human primary liver tumors 显示文摘 | Roskams T de Vos R Guido D | 1998 | J Pathol1998，185，： | 1 |
| 15 | Outcome of hyperleukocytic adult acute myeloid leukaemia:A single-center retrospective study and review of literature显示文摘 | GUIDO N MICHELE N ALESSANDRA T | 2008 | Leukemia Res2008，32，： | 1 |
| 16 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 1 |
| 17 | Extent of pre-operative L-DOPA-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation显示文摘 | Joanna García Thomas Carlsson Máté D?br?ssy Guido Nikkhah Christian Winkler | 2011 | Experimental Neurology2011，，2： | 1 |
| 18 | Introduction to the special issue on normative muhiagent systems 显示文摘 | Guido B Leendert T Harko V | 2008 | Autonomous Agents and Multi-Agent Systems2008，7，1： | 1 |
| 19 | A comparison of different focus functions for use in autofocus algorithms显示文摘 | Frans C A Groen Ian T Young Guido Ligthart | 1985 | Cytometry1985，6，2： | 1 |
| 20 | A microscle langrangian particle model for the dispersion of primary pollutants in a street canyon, sensitivity analysis and first validation rials显示文摘 | Guido L Maatteo T | 1995 | Atmos Environ1995，29，23： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员