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| 1 | Diffusion weighted imaging in the liver显示文摘Diffusion weighted magnetic resonance imaging (DWI) is an imaging technique which provides tissue contrast by the measurement of diffusion properties of water molecules within tissues. Diffusion is expressed in an apparent diffusion coefficient (ADC), which reflects the diffusion properties unique to each type of tissue. DWI has been originally used in neuroradiology. More recently, DWI has increasingly been used in addition to conventional unenhanced and enhanced magnetic resonance imaging (MRI) in other parts of the body. The reason for this delay was a number of technical problems inherent to the technique, making DWI very sensitive to artifacts, which had to be overcome. With assessment of ADC values, DWI proved to be helpful in characterization of focal liver lesions. However, DWI should always be used in conjunction to conventional MRI since there is considerable overlap between ADC values of benign and malignant lesions. DWI is useful in the detection of hepatocellular carcinoma in the cirrhotic liver and detection of liver metastases in oncological patients. In addition, DWI is a promising tool in the prediction of tumor responsiveness to chemotherapy and the follow-up of oncological patients after treatment, as DWI may be capable of detecting recurrent disease earlier than conventional imaging.This review focuses on the most common applications of DWI in the liver. | Petra G Kele Eric J van der Jagt | 2010 | World Journal of Gastroenterology2010，16，13： | 48 |
| 2 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
| 3 | [^11C]methionine PET, histopathology, and survival in primary brain tumors and recurrence显示文摘 | Ceyssens S Van Laere K de Groot T Goffin J Bormans G Mortelmans L | 2006 | 中国神经肿瘤杂志2006，4，3： | 13 |
| 4 | 焦炭特性及其在高炉下部的变化过程显示文摘气化、石墨化和溶解是影响焦炭从高炉软熔带至炉缸间行为的三个主要过程。过去几年在一些专题项目中对这些过程进行了研究。简要叙述并讨论了这些过程的相互作用及其与焦炭特性的关系。对焦炭的气化反应进行了实验室测试研究,用以评价高炉条件下焦炭的特性。用高炉条件下的气化测试装置测试了几种焦炭试样,考查的质量指标包括反应性、结构变化和强度等。用实际尺寸的焦炭块对块状焦炭试样的高温行为进行了评估,将不同种类的焦炭试样加热到2 000℃,以鉴别其在高温下的行为。高温下焦炭将发生石墨化,对高温反应后的强度进行了评定,并作了显微观察,发现了一些现象和组织结构的变化。焦炭与液态渣铁相互作用的研究结果对焦炭在高炉下部的行为有了更好的理解。通过试验研究了焦炭抗液态铁水溶解的性能,对入炉前的焦炭和经高温反应的焦炭分别进行了试验。分析讨论了焦炭的抗气化、抗石墨化和抗铁水溶解性能与其结构、化学成分和强度的关系。 | B van der Velden C J Atkinson T Bakker J R H Stuurwold G J Tijhuis 徐万仁 | 2014 | 世界钢铁2014，，2： | 11 |
| 5 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 6 | 两种新型骨水泥的组织学和生物力学研究显示文摘我们研制了两种可被骨长入的骨水泥:一种是部分可吸收的骨水泥(PRC),以双酚α-甲基丙烯酸甘油酯(Bis-GMA)为基质,混合硅铝陶瓷和可吸收性聚合体颗粒调制成;另一种是磷酸钙骨水泥(CPC),由磷酸三钙、一水磷酸二氢钙、二水磷酸二钙和黄原胶组成。将这两种骨水泥分别植入家兔股骨和胫骨髁的骨缺损中,植入后2、4、12和24周取材,进行组织学观察和生物力学测试。结果发现,CPC组有递增的骨整合,伴有生物降解及巨噬细胞出现,力学测试显示抗压强度在4周之前一直降低,4周后才轻微升高,弹性模量随时间普遍降低。到第4周时,组织学观察还发现新生骨与CPC边缘直接接触。整个观察过程中未发现炎症反应。PRC组,骨整合及生物降解都很轻微,但在各个观察阶段,其抗压强度比松质骨和CPC组高(p<0.05),在4周之前,它的弹性模量高于松质骨和CPC组,4周后低于松质骨。(Bone 25:41S--45S;1999)。 | 卢建熙 I ABOUT G STEPHAN P VAN LANDUYT J DEJOU M FIOCCHI J LEMAITRE J-P PROUST | 2000 | 医用生物力学2000，15，3： | 10 |
| 7 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 8 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 9 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 10 | Kinetics of CO2 with primary and secondary amines in aqueous solutions显示文摘 | Little R J Versteeg G F Van Swaaij W P M | 1992 | Chem Eng Sci1992，47，： | 3 |
| 11 | Biomimetic extraction as a tool to identify chemicals with high bioconcentration potential: an illustration by two fragrances in sewage treatment plant effluents and surface waters显示文摘 | Verbruggen E M J van Loon W M G M and Tonkes M | | Environ Sci Te0，，： | 2 |
| 12 | Effectiveness of bovine microsatellites in resolving paternity cases in American bison显示文摘 | Mommens G Van Zeveren Peclman L J | 1998 | Bison L J Anim Genet1998，28，： | 2 |
| 13 | Factors relevant in bacterial pyrroloquinoline quinone production显示文摘 | van Kleef M A G Duine J A | 1989 | Applied and Environmental Microbiology1989，55，5： | 2 |
| 14 | A randomised, multicentre study of ceftriaxone versus standard therapy in the treatment of lower respiratory tract infections 显示文摘 | de Klerk G J van Steijn J H Lobatto S | 1999 | Int J Antimicrob Agents1999，12，2： | 2 |
| 15 | 二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性:随机安慰剂对照研究(摘要)显示文摘目的 研究接受胰岛素治疗的2型糖尿病患者中,二甲双胍所致维生素B12缺乏(〈150pmol/L)、低浓度维生素B12(150—220pmol/L)的发生率,以及叶酸和同型半胱氨酸的浓度。 | Jolien de Jager Adriaan Kooy Philippe Lehert Michiel G Wulffele Jan van der Kolk Daniel Bets Joop Verburg Ab J M Donker Coen D A Stehouwer 许翎岭(译) | 2010 | 英国医学杂志中文版2010，13，5： | 2 |
| 16 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 17 | Experimental investigation of size effect in concrete and sandstone under uniaxial tension显示文摘 | Van M R A Van J G M | 2000 | Engineering Fracture Mechanics2000，65，： | 2 |
| 18 | Submicron and ultrafine grained hardmetals for microdrills and metal cutting inserts显示文摘 | G Gille B Szesny K Dreyer H van den Berg J Schmidt T Gestrich G Leitner | 2002 | International Journal of Refractory Metals and Hard Materials2002，，1： | 2 |
| 19 | The dissolution of Na2O-MgO-CaO-SiO2 glass in aqueous HF solutions 显示文摘 | SPIERINGS G A C M van DIJK J | 1987 | J Mater Sci1987，22，： | 2 |
| 20 | Mycorrhizal fungal diversity determines plant biodiversity,ecosystem variability and productivity显示文摘 | van der Heijden M G A Klironomos J N Ursic M | 1998 | Nature1998，396，： | 2 |
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