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| 1 | Changing Connectivities of Chinese Cities in the World City Network,2010–2016显示文摘Against the backdrop of the sizable economic growth of China in recent years, this paper uses the most recent data gathering of the Globalization and World Cities(Ga WC) research network to update and supplement earlier research on the shifting global connectivity of Chinese cities. The update consists of an evaluation of the connectivity of Chinese cities in 2016, the supplement of an analysis of the changing position of Chinese cities in the world city network between 2010 and 2016. To this end, we build on a specification of the world city network as an ‘interlocking network' in which producer services firms play the crucial role in city network formation. Information about the presence of leading producer services firms in cities in 2010 and 2016 is used as the input to a bipartite network projection algorithm in order to measure cities' network connectivity. The first set of results discusses the geographies of urban connectivity in the world city network in 2016. The second set of results discusses standardized measures of change to reveal the major dimensions of the transformations between 2010 and 2016. We find that, with the exception of Hong Kong, Macao and Kaohsiung of Taiwan, all Chinese cities record connectivity gains. This wholesale rise in connectivity is nonetheless geographically uneven, with above all Beijing, Chengdu/Chongqing and Changsha/Wuhan becoming more connected. We conclude that the wholesale rise of Chinese cities in the world city network and their changing trajectories in the post-crisis era are embedded in shifting external and internal political economies. | Ben DERUDDER CAO Zhan LIU Xingjian SHEN Wei DAI Liang ZHANG Weiyang Freke CASET Frank WITLOX Peter J.TAYLOR | 2018 | Chinese Geographical Science2018，28，2： | 17 |
| 2 | Regulation of the water status in three co-occurring phreatophytes at the southern fringe of the Taklamakan Desert显示文摘Aims We investigated the regulation of the water status in three predominant perennial C3 phreatophytes(Alhagi sparsifolia,Populus euphratica,Tamarix ramosissima)at typical sites of their occurrence at the southern fringe of the hyperarid Taklamakan Desert(north-west China).Methods In the foreland of the river oasis of Qira(Cele),we determined meteorological variables,plant biomass production,plant water potentials(WL)and the water flux through the plants.We calculated the hydraulic conductance on the flow path from the soil to the leaves(kSL)and tested the effects of kSL,WL and the leaf-to-air difference in the partial pressure of water vapour(Dw)on stomatal regulation using regression analyses.Important Findings Despite high values of plant water potential at the point of turgor loss,all plants sustained WL at levels that were high enough to maintain transpiration throughout the growing season.In A.sparsifolia,stomatal resistance(rs;related to leaf area or leaf mass)was most closely correlated with kSL;whereas in P.euphratica,~70%of the variation in rs was explained by Dw.In T.ramosissima,leaf area-related rs was significantly correlated with WL and kSL.The regulation mechanisms are in accordance with the growth patterns and the occurrence of the species in relation to their distance to the ground water. | Frank M.Thomas Andrea Foetzki Dirk Gries Helge Bruelheide Xiangyi Li Fanjiang Zeng Ximing Zhang | 2008 | Journal of Plant Ecology2008，1，4： | 13 |
| 3 | Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model显示文摘Osteoarthritis(OA) is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor(EGFR) signaling as an important regulator of cartilage matrix degradation during epiphyseal cartilage development. To study its function in OA progression, we performed surgical destabilization of the medial meniscus(DMM) to induce OA in two mouse models with reduced EGFR activity, one with genetic modification(EgfrWa5/1mice) and the other one with pharmacological inhibition(gefitinib treatment). Histological analyses and scoring at 3 months post-surgery revealed increased cartilage destruction and accelerated OA progression in both mouse models. TUNEL staining demonstrated that EGFR signaling protects chondrocytes from OA-induced apoptosis, which was further confirmed in primary chondrocyte culture. Immunohistochemistry showed increased aggrecan degradation in these mouse models, which coincides with elevated amounts of ADAMTS5 and matrix metalloproteinase 13(MMP13), the principle proteinases responsible for aggrecan degradation, in the articular cartilage after DMM surgery. Furthermore, hypoxia-inducible factor 2a(HIF2a), a critical catabolic transcription factor stimulating MMP13 expression during OA, was also upregulated in mice with reduced EGFR signaling. Taken together, our findings demonstrate a primarily protective role of EGFR during OA progression by regulating chondrocyte survival and cartilage degradation. | Xianrong Zhang Ji Zhu Fei Liu Yumei Li Abhishek Chandra L Scott Levin Frank Beier Motomi Enomoto-Iwamoto Ling Qin | 2014 | Bone Research2014，2，3： | 9 |
| 4 | CONSTRAINED RATIONAL CUBIC SPLINE AND ITS APPLICATION显示文摘In this paper, a kind of rational cubic interpolation function with linear denominator is constructed. The constrained interpolation with constraint on shape of the interpolating curves and on the second-order derivative of the interpolating function is studied by using this interpolation, and as the consequent result, the convex interpolation conditions have been derived. | Qi Duan Huan-ling Zhang Xiang Lai Nan Xie Fu-hua(Frank)Cheng | 2001 | Journal of Computational Mathematics2001，19，2： | 9 |
| 5 | Qingbaikouan and Crygenian in South China:Constraints by SHRIMP Zircon U-Pb dating显示文摘The Qingbaikouan System is the lowest unit of the Neoproterozoic Erathem in Chinese stratigraphic succession,and it now provides a precise geochronological framework and geological time scale for mapping and stratal correlation in China.However,a sensitive high-resolution ion microprobe(SHRIMP)U-Pb zircon age date(1368±12 Ma)obtained from a bentonite in the Qingbaikouan Xiamaling Formation indicates that it belongs to the Mesoproterozoic Erathem instead.This change is a milestone in understanding the Precambrian Stratigraphic Time Scale in China,and it has had great influence on Precambrian correlations in Asia.Otherwise,a large amount of geochronological work has been done in the'Jiangnan Orogen Belt'of South China,and new isotopic data have redefined the traditional recognition of metamorphosed Mesoproterozoic strata from the Sibao orogeny to the Neoproterozoic Erathem.Based on SHRIMP zircon U-Pb age data,the authors regard the Sibao orogeny(equal to the Wuling orogeny)as a movement at ca 820 Ma,meaning that the Sibao orogeny was not equivalent to the Grenvillian orogeny.Finally,we report here the first SHRIMP U-Pb age of the boundary between the top of the Qingbaikouan Gongdong Formation(786.8±5.6 Ma)and the bottom of the Chang’an(diamictite)Formation(778.4±5.2 Ma),which is the age of the lowest diamictite of the Nanhuan System in China. | GAO Linzhi DING Xiaozhong YIN Chongyu ZHANG Chuanheng Frank R. ETTENSOHN | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 8 |
| 6 | A novel deletion mutation, c.1296delT in the BCOR gene, is associated with oculo-facio-cardio-dental syndrome显示文摘The purpose of the present study was to analyze the clinical phenotypes of a girl with oculo-facio-cardio-dental(OFCD)syndrome and to identify the potential pathogenic mutation responsible for her disease. The patient underwent detailed clinical examinations and phenotype data were collected over a follow-up period of 9 years. Mutation analysis of the candidate gene BCOR was performed with polymerase chain reaction and Sanger sequencing. BCOR of 60 unrelated normal individuals were also sequenced as a control group. Clinical phenotyping and follow-up study results indicate that this patient had multiple system anomalies including ocular, facial, cardiac, dental, and limb malformations. In addition, papilloma of the choroid plexus was identified, which represents the first report of this phenotype in an OFCD patient. A novel deletion mutation, c.1296 delT in exon4 of the BCOR gene, was identified in this patient and was not found in her parents or in 60 normal unrelated individuals. This deletion was a frameshift mutation and is proposed to encode a premature stop codon, thus producing a truncated protein. Our patient fitted the diagnostic criteria for OFCD syndrome and we report the first papilloma of the choroid plexus in an OFCD patient, expanding the recognized phenotypic spectrum of this disease. Meanwhile, we identified a novel deletion mutation that may cause OFCD syndrome. | Jingshang Zhang Hongyan Jia Jinda Wang Ying Xiong Jing Li Xiaoxia Li Jing Zhao Xiaohui Zhang Qisheng You Guyu Zhu Frank F.Tsai Mark Espina Xiuhua Wan | 2019 | Science China(Life Sciences)2019，62，1： | 6 |
| 7 | Environmental changes during the past 13500 cal. a BP deduced from lacustrine sediment records of Lake Qinghai, China显示文摘A 475-cm long sediment core (QH-2005) from Lake Qinghai was used to carry out multi-proxy analysis of δ18O and body length of ostracod valves and redness and grain size of sediments, in order to reconstruct environ-mental changes during the past 13500 cal. a BP. The age model was based on 6 14C dates for bulk orgnic carbon (BOC) and 2 14C dates for lignin. The lignin 14C dates are apparently younger than the corresponding layers' BOC 14C dates, indicating that the reservoir age varied from 728 to 1222 a since the Late Glacial and from 2390 to 2490 a immediately before the pre-bomb era. Hence, the 14C age model for Core QH-2005 was corrected by the changing reservoir age. Ostracod δ18O values were primarily related to dilution and evaporative enrichment of the lake water. The reconstructed salinity based on ostracod body length coincides well with ostracod δ18O values. High redness and mean grain size (MZ) values indicate increased riverine supply to Lake Qinghai associated with increasing monsoon rainfall. Multi-proxy results show that climate during 13500-10900 cal. a BP was relatively cold and dry with fre-quent short-term fluctuations; a warm and wet climate began at about 10900 cal. a BP and culminated around 6500 cal. a BP as a result of monsoon strengthening; the climate became cold and dry afterwards and has remained rela-tively stable since 3400 cal. a BP. Our data also reveal short-term (millennial/centennial timescales) climatic fluctua-tions including: Younger Dryas events, ice-rafting events 8 and 1 (by ~11000 cal. a BP and ~1600 cal. a BP respec-tively), 8200 cal. a BP cold event, Little Ice Age and the Medieval Warm Period. | WANG Yong SHEN Ji XU Xingna LIU Xingqi SIROCKO Frank ZHANG Enlou JI Junfeng | 2011 | Chinese Journal Of Geochemistry2011，30，4： | 6 |
| 8 | Appropriately adapted properties of hot-extruded Zn-0.5Cu-xFe alloys aimed for biodegradable guided bone regeneration membrane application显示文摘Appropriately adapted comprehensive mechanical properties,degradation behavior and biocompatibility are prerequisites for the application of Zn-based biodegradable implants.In this study,hot-extruded Zn-0.5Cu-xFe(x=0.1,0.2 and 0.4 wt%)alloys were fabricated as candidates for biodegradable materials for guided bone regeneration(GBR)membranes.The hot-extrusion process and Cu alloying were expected mostly to enhance the mechanical properties,and the Fe alloying was added mainly for regulating the degradation.The microstructure,mechanical properties and in vitro degradation behavior were systematically investigated.The ZnCuFe alloys were composed of a Zn matrix and FeZn13 phase.With increasing Fe content,a higher FeZn13 phase precipitation with larger particles was observed.Since elongation declined significantly until fracture with increasing Fe content up to 0.4 wt%,the ZnCuFe(0.2 wt%)alloy achieved a good balance between mechanical strength and ductility,with an ultimate tensile strength of 202.3 MPa and elongation at fracture of 41.2%.Moreover,the addition of Fe successfully accelerated the degradation of ZnCuFe alloys.The ZnCuFe(0.2 wt%)alloy showed relatively uniform corrosion in the long-term degradation test.Furthermore,extracts of the ZnCuFe(0.2 wt%)alloy showed no apparent cytotoxic effects against L929 fibroblasts,Saos-2 osteoblasts or TAg periosteal cells.The ZnCuFe(0.2 wt%)alloy exhibited the potential to inhibit bacterial adhesion of Streptococcus gordonii and mixed oral bacteria.Our study provides evidence that the ZnCuFe(0.2 wt%)alloy can represent a promising material for the application as a suitable GBR membrane. | Wentai Zhang Ping Li Gang Shen Xiaoshan Mo Chao Zhou Dorothea Alexander Frank Rupp Jürgen Geis-Gerstorfer Haijun Zhang Guojiang Wan | 2021 | Bioactive Materials2021，6，4： | 6 |
| 9 | Development mechanism of internal local corrosion of X80 pipeline steel显示文摘The occurrence and development mechanism of internal local corrosion has always been a controversial topic,and especially under flow conditions.In this paper,an improved high shear force loop was experimentally used,and local flow field is induced by simulating corrosion defects on the surface of X80 pipeline steel specimens.The characteristics of corrosion products deposited on the surface of specimens in CO2-saturated NACE solution were investigated by means of electrochemical impedance spectroscopy(EIS),scanning electron microscopy(SEM),X-ray diffraction(XRD),and energy dispersive spectrometry(EDS).The 3D micromorphology of the corrosion test surface after remove the corrosion scale used to measure the size of localized corrosion pit.Under the influence of local defects,the wall shear stress(WSS)and turbulent kinetic energy of local flow fields enhanced significantly,and pressure fluctuations in local flow field were induced.The results showed that the characteristics of surface corrosion products varied with flow velocity.The corrosion scales formed in various regions of specimens with defects exhibited different surface micro-morphologies and chemical compositions.Overall,these data offer new perspectives for better understanding the mechanisms behind local corrosion. | Zhuowei Tan Liuyang Yang Dalei Zhang Zhenbo Wang Frank Cheng Mingyang Zhang Youhai Jin | 2020 | Journal of Materials Science & Technology2020，47，14： | 6 |
| 10 | Two dimensional metal halide perovskites: Promising candidates for light-emitting diodes显示文摘Two dimensional halide perovskites are emerging as attractive electroluminescent materials for developing high-performance light-emitting devices owing to their unique structures and/or superior optoelectronic properties.This review begins with an introduction to the working principles of and the key figures for evaluating the performance of LEDs.Secondly,the structure and optoelectronic properties of two dimensional perovskites are summarized and discussed. Their advantages in LED application over their 3D counterparts are systematically analyzed.Following the theoretically discussion,the progresses on the preparation of two dimensional perovskite materials as well as their performances in LEDs have been summarized. At last,several challenges and prospects are presented for achieving high performance 2D perovskite-based LEDs. | Lu Zhang Yucheng Liu Zhou Yang Shengzhong(Frank)Liu | 2019 | Journal of Energy Chemistry2019，28，10： | 5 |
| 11 | 120 mm Single-crystalline perovskite and wafers: towards viable applications显示文摘As the large single-crystalline silicon wafers have revolutionized many industries including electronics and solar cells, it is envisioned that the availability of large single-crystalline perovskite crystals and wafers will revolutionize its broad applications in photovoltaics, optoelectronics, lasers, photodetectors, light emitting diodes(LEDs), etc. Here we report a method to grow large single-crystalline perovskites including single-halide crystals: CH3NH3PbX3(X=I, Br, Cl), and dual-halide ones:CH3NH3Pb(ClxBr1.x)3 and CH3NH3Pb(BrxI1.x)3, with the largest crystal being 120 mm in length. Meanwhile, we have advanced a process to slice the large perovskite crystals into thin wafers. It is found that the wafers exhibit remarkable features:(1)its trap-state density is a million times smaller than that in the microcrystalline perovskite thin films(MPTF);(2) its carrier mobility is 410 times higher than its most popular organic counterpart P3HT;(3) its optical absorption is expanded to as high as910 nm comparing to 797 nm for the MPTF;(4) while MPTF decomposes at 150 °C, the wafer is stable at high temperature up to270 °C;(5) when exposed to high humidity(75% RH), MPTF decomposes in 5 h while the wafer shows no change for overnight;(6) its photocurrent response is 250 times higher than its MPTF counterpart. A few electronic devices have been fabricated using the crystalline wafers. Among them, the Hall test gives low carrier concentration with high mobility. The trap-state density is measured much lower than common semiconductors. Moreover, the large SC-wafer is found particularly useful for mass production of integrated circuits. By adjusting the halide composition, both the optical absorption and the light emission can be fine-tuned across the entire visible spectrum from 400 nm to 800 nm. It is envisioned that a range of visible lasers and LEDs may be developed using the dual-halide perovskites. With fewer trap states, high mobility, broader absorption, and humidity resistance, it is expected that solar cells with high stable efficiency maybe attainable using the crystalline wafers. | Yucheng Liu Xiaodong Ren Jing Zhang Zhou Yang Dong Yang Fengyang Yu Jiankun Sun Changming Zhao Zhun Yao Bo Wang Qingbo Wei Fengwei Xiao Haibo Fan Hao Deng Liangping Deng Shengzhong (Frank) Liu | 2017 | Science China Chemistry2017，60，10： | 5 |
| 12 | Path towards high-efficient kesterite solar cells显示文摘Kesterite structure semiconductor Cu_2ZnSn(S,Se)_4 is one of the most promising candidate as a light absorber material to overtake the next generation of thin film solar cells, owing to its low cost, non-toxic,and earth abundant source materials. The Shockley-Queisser limit of the single junction Cu_2ZnSn(S,Se)_4 solar cell is over 30%, signifying a large potential of this family of solar cells. In the past years, with the development of synthesis techniques, Cu_2ZnSn(S,Se)_4 solar cells have attracted considerable attention and the power conversion efficiency of Cu_2ZnSn(S,Se)_4 solar cell has experienced a rapid progress.Presently, the certified champion efficiency of CZTSSe solar cells has reached to 12.6%, which is far below the efficiency of Cu(In,Ga)Se_2 solar cell. In this review, the developments of Cu_2ZnSn(S,Se)_4 solar cells in recent years are briefly reviewed. Then the fundamental understanding of Cu_2 Zn Sn(S,Se)4 solar cells is introduced, including materials and device structure, as well as the band alignment of hetero-junction and their impacts on device performance. After that, we mainly review the progress and achievements in the preparation processes, through vacuum and non-vacuum based processes. Finally, we outline the challenges and perspectives of this promising solar cell. | Dongxiao Wang Wangen Zhao Yi Zhang Shengzhong(Frank)Liu | 2018 | Journal of Energy Chemistry2018，27，4： | 4 |
| 13 | Stand structure and productivity of Populus euphratica along a gradient of groundwater distances at the tarim River(NW china)显示文摘Aims Along central-Asian rivers in arid regions,lowering of the ground-water level constitutes a major threat to the riparian forests,whose tree layers are dominated by Euphrates poplar(Populus euphratica).Some of these fragile ecosystems are supplied with additional(‘eco-logical’)water for protection and conservation.We investigated interrelationships among groundwater distance,stand structure and above-ground wood production(at the tree and the stand level)in P.euphratica stands along a groundwater gradient(distances of 2.0-12.0 m)that also included a plot supplied with‘ecological water’.Methods We measured the height,diameter at breast height and basal area of poplar trees and determined the annual above-ground wood production for the three most recent years on the basis of tree-ring analyses and allometric regressions at three sites at the upper,mid-dle and lower reaches of the tarim River,Xinjiang,NW china.Important Findingsthe distribution of age classes differed significantly among the plots:in accordance with their life histories,stands growing at a larger distance to the groundwater harboured a larger fraction of old trees(>80 years)and,in most cases,a smaller fraction of young trees(≤20 years).the annual above-ground wood production per ha was highest on a plot with a short groundwater distance(2.0 m;maxi-mum of the 3-year investigation period:3.0 t ha−1 a−1)and lowest,at a plot with a large distance to the water table(6.6 m;minimum:0.23 t ha^(−1)a^(−1)).However,the plot located close to the groundwater(and to the river)at the middle reaches exhibited a relatively large interannual variation in above-ground wood production,which can be attributed to interannual variations in the river discharge.At the middle and the lower reaches,these interannual variations on plots with the most favourable water supply were even more obvious at the tree level.For the fraction of mature trees(60-99 years old),no significant differences in above-ground wood production were found between the plots with the most and the least favourable water supply.Overall,the productivity at the stand level was most closely correlated with the stand density(number of trees per ha,tree cover percentage).Productivity was negatively related to tree age,whereas groundwater distance alone was not a good predictor of above-ground wood production.In conclusion,vigorous growth of P.euphratica is possible at sites with groundwater distances of up to 12 m.Supply with‘ecological water’may be beneficial to trees growing at groundwater distances not larger than~6 m.However,allocation of water should focus on stands with a short distance to the groundwater because only under these conditions,natural gen-erative reproduction of the poplars is possible. | Frank M.Thomas Michael Jeschke Ximing Zhang Petra Lang | 2017 | Journal of Plant Ecology2017，10，5： | 4 |
| 14 | Delivery of Cas9 Protein into Mouse Zygotes through a Series of Electroporation Dramatically Increases the Efficiency of Model Creation显示文摘Previously we established Zygote Electroporation of Nucleases(ZEN) technology as an efficient and high-throughput way to generate genetically modified mouse models.However,there were significant variations of the targeting efficiency among different genomic loci using our previously published protocol.In this study,we improved the ZEN technology by delivering Cas9 protein into mouse zygotes through a series of electroporation.Using this approach,we were able to introduce precise nucleotide substitutions,large segment deletion and short segment insertion into targeted loci with high efficiency. | Wenbo Wang Peter M.Kutny Shannon L.Byers Charles J.Longstaff Michael J.DaCosta Changhong Pang Yingfan Zhang Robert A.Taft Frank W.Buaas Haoyi Wang | 2016 | Journal of Genetics and Genomics2016，43，5： | 4 |
| 15 | Novel hierarchical structure of MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites for dramatically enhanced electromagnetic absorbing properties显示文摘In order to prevent the microwave leakage and mutual interference,more and more microwave absorbing devices are added into the design of electronic products to ensure its routine operation.In this work,we have successfully prepared MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) hierarchical composites by one-pot hydrothermal method and focused on the relationship between structures and electromagnetic absorbing properties.Supported by comprehensive characterizations,M0S_(2) nanosheets were proved to be anchored on the surface and interlayer of Ti_(3)C_(2)T_(x) through a hydrothermal process.Additionally,TiO_(2) nanoparticles were obtained in situ.Due to these hierarchical structures,the MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites showed greatly enhanced microwave absorbing performance.The MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites exhibit a maximum reflection loss value of -33.5 dB at 10.24 GHz and the effective absorption bandwidth covers 3.1GHz(13.9-17 GHz)at the thickness of 1.0 mm,implying the features of wide frequency and light weight.This work in the hierarchical structure of MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites opens a promising door to the exploration of constructing extraordinary electromagnetic wave absorbents. | Heng DU Qipeng ZHANG Biao ZHAO Frank MARKEN Qiancheng GAO Hongxia LU Li GUAN Hailong WANG Gang SHAO Hongliang XU Rui ZHANG Bingbing FAN | 2021 | Journal of Advanced Ceramics2021，10，5： | 4 |
| 16 | OPTIMAL POLICY WITH A TOTAL ORDER QUANTITY COMMITMENT CONTRACT IN THE PRESENCE OF A SPOT MARKET显示文摘In this paper,the optimal policy is considered when the buyer faces two supply sources:one is the contract supplier from which the buyer orders over a specific contract period(say,a year) at a pre-agreed price,and the other is the spot market.However,when ordering from the contract supplier,the buyer must fulfill a pre-determined total order quantity,or the so-called definite total order quantity commitment,over the whole contract period.In other words,the commitment secures the buyer a fixed price but obliges him/her a total order quantity over the contract period.Although the spot market gives the buyer more flexibility in terms of order quantities,its prices are volatile.Such a combination of contract and spot procurements is often observed in practice.Within the contract period,there are multiple sub-periods,during each of which the buyer reviews the inventory,issues an individual order,and uses the on-hand inventory to meet the random demand.Thus,in each(ordering) period,the buyer will weigh between the current known spot price(by procuring from the spot market) and a lower future price(by waiting while consuming the remaining commitment).An optimal dual ordering policy is characterized for each period,depending on the on-hand inventory level,the spot price,and the remaining commitment quantity.The optimal policy in each period is also shown to be independent of the contract price.Through a numerical study,the inventory cost is demonstrated to be(1) insensitive to the contract price when the total commitment quantity is lower than the total expected demand over the contract period and(2) non-increasing in the variability of spot prices. | Wei ZHANG Youhua (Frank) CHEN Zhongsheng HUA Weili XUE | 2011 | Journal of Systems Science and Systems Engineering2011，20，1： | 3 |
| 17 | Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence显示文摘Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C(CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids, was found to be a critical regulator of cancer cell senescence. However, whether loss of CPT1C could induce senescence as a result of lipotoxicity remains unknown. An LC/MS-based lipidomic analysis of PANC-1,MDA-MB-231, HCT-116 and A549 cancer cells was conducted after siRNA depletion of CPT1C. Cellular lipotoxicity was further confirmed by lipotoxicity assays. Significant changes were found in the lipidome of CPT1C-depleted cells, including major alterations in fatty acid, diacylglycerol, triacylglycerol, oxidative lipids, cardiolipin, phosphatidylglycerol, phosphatidylcholine/phosphatidylethanolamine ratio and sphingomyelin. This was coincident with changes in expressions of mRNAs involved in lipogenesis.Histological and biochemical analyses revealed higher lipid accumulation and increased malondialdehyde and reactive oxygen species, signatures of lipid peroxidation and oxidative stress. Reduction of ATP synthesis, loss of mitochondrial transmembrane potential and down-regulation of expression of mitochondriogenesis gene m RNAs indicated mitochondrial dysfunction induced by lipotoxicity, which could further result in cellular senescence. Taken together, this study demonstrated CPT1C plays a critical role in the regulation of cancer cell lipotoxicity and cell senescence, suggesting that inhibition of CPT1C may serve as a new therapeutic strategy through induction of tumor lipotoxicity and senescence. | Huizhen Zhang Yongtao Wang Lihuan Guan Yixin Chen Panpan Chen Jiahong Sun Frank J.Gonzalez Min Huang Huichang Bi | 2021 | Journal of Pharmaceutical Analysis2021，11，3： | 3 |
| 18 | A comparative investigation of the properties of coal-water slurries prepared from Australia and Shenhua coals显示文摘Two coal samples of similar rank were chosen from Australia and China to investigate the differences in Coal-Water Slurry (CWS) made from them. The effect of ash content and particle size gradation on these properties was also studied. Different grinding times were used when grinding the two coals and particle size analysis of these ground coals was used to select samples with a ''double-peak'' particle size distribution. All the ''double-peak'' samples were used to prepare a CWS. The concentration, viscosity, fluidity, and stability of each CWS were measured. The results show that the properties of a CWS prepared from a coal sample with a ''double-peak'' size distribution are better than those CWS prepared from samples with a mono-modal particle distribution. The ash content of Australian coal is 21.72% higher than the ash content of Shenhua coal. The highest coal concentration in slurry from the Australia coal is 11.01% higher than in CWS from the Shenhua coal. The fluidity and stability of the CWS prepared from the Australian coal are both better than the fluidity and stability of slurry prepared from Shenhua coal. High ash content in the Australian coal improves the pulping results of a CWS made from it. | Yun Zengjie Wu Guoguang Meng Xianliang Zhang Yuliang Shi Frank He Yaqun Luo Xiaoqiang | 2011 | Mining Science and Technology2011，21，3： | 3 |
| 19 | High-quality perovskite MAPbI_3 single crystals for broad-spectrum and rapid response integrate photodetector显示文摘Organic–inorganic single-crystalline perovskites have attracted significant attentions due to their exceptional progress in intrinsic properties' investigation and applications in photovoltaics and optoelectronics. In this study, the large perovskite CH3NH3PbI3 single crystal with the largest length of 80 mm was prepared through the method of inverse-temperature crystallization. Meanwhile, the mass production of integrate photodetectors have been fabricated on the single-crystalline wafer and the photoresponse performances were investigated. The results show that the single-crystalline photodetectors have broad spectrum response to 900 nm, rapid response speed(<40 μs) and excellent stability. These findings are of great importance for future promising perovskite single crystalline for integrated photoelectronic application. | Yunxia Zhang Yucheng Liu Zhou Yang Shengzhong(Frank)Liu | 2018 | Journal of Energy Chemistry2018，27，3： | 3 |
| 20 | Fabrication of copper nanorods by low-temperature metal organic chemical vapor deposition显示文摘Copper nanorods have been synthe-sized in mesoporous SBA-15 by a low-temperature metal organic chemical vapor deposition (MOCVD) employing copper (II) acetylacetonate, Cu(acac)2, and hydrogen as a precursor and reactant gas, re- spectively. The hydrogen plays an important role in chemical reduction of oganometallic precursor which enhances mass transfer in the interior of the SBA-15 porous substrate. Such copper nanostructures are of great potentials in the semiconductor due to their unusual optical, magnetic and electronic properties. In addition, it has been found that chemically modi- fying the substrate surface by carbon deposition is crucial to such synthesis of copper nanostructures in the interior of the SBA-15, which is able to change the surface properties of SBA-15 from hydrophilic to hydrophobic to promote the adsorption of organic cupric precursor. It has also been found that the copper nanoparticles deposited on the external sur- face are almost eliminated and the copper nanorods are more distinct while the product was treated with ammonia. This approach could be achieved under a mild condition: a low temperature (400℃) and vac-uum (2 kPa) which is extremely milder than the con- ventional method. It actually sounds as a foundation which is the first time to synthesize a copper nanorod at a mild condition of a low reaction temperature and pressure. | ZHANG Ying Frank Leung-Yuk Lam HU Xijun YAN Zifeng | 2006 | Chinese Science Bulletin2006，51，21： | 3 |
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