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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | A hybrid approach using the analytic hierarchy process and integer programming to screen weapon systems projects 显示文摘 | Greiner M A Fowler J W Shunk D L | 2003 | IEEE Transactions on Engineering Management2003，50，2： | 1 |
| 3 | Relationship of pretreatment transurethral resection of the prostate to survival without distant metastases in patients treated with ^125I-implantation for localized prostatic cancer显示文摘 | Fowler J E Jr Fisher H A Kaiser D L | 1984 | Cancer1984，53，9： | 1 |
| 4 | Canopy light environment and yield of narrow - row cotton as affected by canopy architecture显示文摘 | Reta - Sanchez D G Fowler J L | 2002 | Agrono- my Journal2002，94，： | 1 |
| 5 | Choledocholithiasis:endoscopic vers 118 laparopie management显示文摘 | Heili M J Wintz N K Fowler D L | | 0，，02： | 1 |
| 6 | Deposition of atmospheric pollutants to the LOIS area显示文摘 | Smith R I Cape J N Binnie J Murray T D Young M and Fowler D | 1997 | Science of the Total Environment1997，，： | 1 |
| 7 | The neural control of micturition 显示文摘 | Fowler C J Griffiths D Groat WC | 2008 | Nat Rev Neuro2008，9，： | 1 |
| 8 | Predictors of first repeat biopsy cancer detection with suspected local stage prostate cancer显示文摘 | Fowler J E Jr Bigler S A Miles D | 2000 | J Urol2000，163，3： | 1 |
| 9 | Barriers to Swift, Even Flow in the Internal Supply Chain of Perioperative Surgical Services De- partment: A Case Study显示文摘 | FREDENDALL L D CRAIG J B FOWLER P J etal | 2009 | Decision Sciences2009，40，2： | 1 |
| 10 | Melanotic neuroectodermal tumor of infancy: clinical, radiological, and pathological features显示文摘 | Fowler DJ Chisholm J Roebuck D | 2006 | Fetal Pediatr Pathol2006，25，2： | 1 |
| 11 | Computational Social Science显示文摘 | Lazer D Pentland A Adamic L Aral S Barabasi A L Brewer D Christakis N Contractor N Fowler J Gutmann M Jebara T King G Macy M Roy D Van Alstyne M | | 0，，5915： | 1 |
| 12 | Imaging the effects of methylphenidate on brain dopamine:new model on its therapeutic actions for attention-deficit/hyperactivity disorder显示文摘 | Volkow N D Wang G J Fowler J S | 2005 | Biol Psychiatry2005，57，11： | 1 |
| 13 | Heritability of cooperative behavior in the trust game显示文摘 | Cesarini D Dawes C T Fowler J H | 2008 | PNAS2008，105，10： | 1 |
| 14 | Addiction: beyond dopamine reward circuitry显示文摘 | Volkow N D Wang G J Fowler J S | 2011 | Proc Natl Acad Sci U S A2011，108，15： | 1 |
| 15 | Quantifying the effect of urban tree planting on concentrations and depositions of PMI0 in two UK conurbations显示文摘 | McDonald A G Bealey W J Fowler D | 2007 | Atmospheric Environment2007，41，38： | 1 |
| 16 | Addiction, a disease of compulsion and drive : involvement of the orbitofrontal cortex 显示文摘 | Volkow N D Fowler J S | 2000 | Cereb Cortex2000，10，3： | 1 |
| 17 | The global exposure of forest ecosystems to air pollutants 显示文摘 | Fowler D Cape J N Coyle M | 1999 | Water Air and Soil Pollution1999，116，1： | 1 |
| 18 | A decade of functional brain imaging applied to bladder control 显示文摘 | Fowler C J Griffiths D J | 2010 | Neurourol Urodyn2010，29，： | 1 |
| 19 | Canopy light environment and yield of narrow-row corron as affected by canopy architecture显示文摘 | RETA-SANCHEZ D G FOWLER J L | 2002 | Agronmy Journal2002，94，： | 1 |
| 20 | Some key environmental variables controlling nitrous oxide emissions from agricultural and semi-natural soils in Scotland显示文摘 | Skiba U M MacDonald J Fowler D | 1998 | Atmospheric Environment1998，32，： | 1 |
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