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| 1 | Non-viral causes of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignancy and represents an international public health concern as one of the most deadly cancers worldwide.The main etiology of HCC is chronic infection with hepatitis B and hepatitis C viruses.However,there are other important factors that contribute to the international burden of HCC.Among these are obesity,diabetes,non-alcoholic steatohepatitis and dietary exposures.Emerging evidence suggests that the etiology of many cases of HCC is in fact multifactorial,encompassing infectious etiologies,comorbid conditions and environmental exposures.Clarification of relevant non-viral causes of HCC will aid in preventative efforts to curb the rising incidence of this disease. | Wojciech Blonski David S Kotlyar Kimberly A Forde | 2010 | World Journal of Gastroenterology2010，16，29： | 25 |
| 2 | Colorectal cancer in patients under 50 years of age:A retrospective analysis of two institutions' experience显示文摘AIM:To investigate the epidemiological characteristics of colorectal cancer(CRC)in patients under 50 years of age across two institutions.METHODS:Records of patients under age 50 years of age who had CRC surgery over a 16 year period were assessed at two institutions.The following documents where reviewed:admission notes,operative notes,and discharge summaries.The main study variables included:age,presenting symptoms,family history,tumor location,operation,stage/differentiation of disease,and post operative complications.Stage of disease was classified according to the American Joint Committee on Cancer TNM staging system:tumor depth;node status;and metastases.RESULTS:CRC was found in 180 patients under age50 years(87 females,93 males;mean age 41.4±6.2years).Young patients accounted for 11.2%of cases during a 6 year period for which the full data set wasavailable.Eight percent had a 1stdegree and 12%a 2nd degree family CRC history.Almost all patients(94%)were symptomatic at diagnosis;common symptoms included:bleeding(59%),obstruction(9%),and abdominal/rectal pain(35%).Evaluation was often delayed and bleeding frequently attributed to hemorrhoids.Advanced stage CRC(Stage 3 or 4)was noted in 53%of patients.Most tumors were distal to the splenic flexure(77%)and 39%involved the rectum.Most patients(95%)had segmental resections;6 patients had subtotal/total colectomy.Poorly differentiated tumors were noted in 12%and mucinous lesions in 19%of patients of which most had Stage 3 or 4 disease.Twenty-two patients(13%)developed recurrence and/or progression of disease to date.Three patients(ages 42,42and 49 years)went on to develop metachronous primary colon cancers within 3 to 4 years of their initial resection.CONCLUSION:CRC was common in young patients with no family history.Young patients with symptoms merit a timely evaluation to avoid presentation with late stage CRC. | Elizabeth A Myers Daniel L Feingold Kenneth A Forde Tracey Arnell Joon Ho Jang Richard L Whelan | 2013 | World Journal of Gastroenterology2013，19，34： | 9 |
| 3 | Budd-Chiari syndrome:A single-center experience显示文摘AIM:To investigate challenges,risk factors,prognostic indicators,and treatment outcomes associated with Budd-Chiari syndrome(BCS)at a tertiary care center.METHODS:A retrospective cohort study was conducted at the University of Pennsylvania in patients with a diagnosis of BCS or hepatic vein thrombosis.All patients receiving care at the University of Pennsylvania,and who had at least 2 clinical encounters in the University of Pennsylvania Health system from January1,2008 to September 10,2013 were eligible for study inclusion.Data were extracted from the electronic medical record of each patient,and recorded in a secure Research Electronic Data Capture database.Logistic regression analyses were applied to identify predictors of outcome of liver transplant(LT)or death.RESULTS:Between January 1,2008 and September10,2013,forty-seven patients were identified.Median age was 42.4 years.Thirty-one(66.0%)were women.A majority were Caucasian(68.1%).At diagnosis,43(91.5%)patients had ascites,27(57.4%)patients had a hematologic disorder associated with a hypercoagulable state and 26(55.3%)had cirrhosis.Forty(85.1%)patients were on anticoagulation(AC),30(63.8%)of whom were maintained on warfarin.Two patients(4.3%)underwent thrombolytic therapy.A transjugular intrahepatic portosystemic shunt(TIPS)was placed in21(44.7%)patients,19(90.5%)of whom were also on AC.Twenty-one(44.7%)received AC alone.Over a median of 974 d,8(17.0%)patients received LT,and10(21.3%)died.The median time from listing to death was 26 mo[interquartile range(IQR)=16,65)].TIPS with AC was utilized more frequently in younger patients(P=0.02).Age,cirrhosis and chronic kidney disease(CKD)were significant predictors of LT or death.CONCLUSION:AC alone was employed as frequently as TIPS with AC,though the latter was used more frequently in younger patients with polycythemia vera.There were no significant differences in treatment outcome regardless of the therapeutic intervention employed.Significant predictors of poor prognosis included age,cirrhosis and CKD. | Tanya M Pavri Alan Herbst Rajender Reddy Kimberly A Forde | 2014 | World Journal of Gastroenterology2014，20，43： | 2 |
| 4 | Do statins reduce hepatitis C RNA titers during routine clinical use?显示文摘AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral titers.RESULTS: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy. | Kimberly A Forde Connie Law Rose O’Flynn David E Kaplan | 2009 | World Journal of Gastroenterology2009，15，40： | 2 |
| 5 | Theory and Performance of Narrow Correlator Spacing in a GPS Receiver显示文摘 | Van Dierendonck A J Fenton P Ford T | 1992 | Navigation1992，39，3： | 1 |
| 6 | Clinical application of the P3 component of event-related potentials 显示文摘 | Pfefferbraum A Wenegrat BG Ford JM | 1984 | Electroencephalogr Clin Neurophysiol1984，59，： | 1 |
| 7 | Psychological correlates of flow in sport显示文摘 | Jackson S A Kiniecik j C Ford S | 1998 | Journal of Sport and Exercise Psychology1998，20，3： | 1 |
| 8 | Cosmic strings and black holes显示文摘 | Aryal M Ford L Vilenkin A | 1986 | Phys Rev1986，34，： | 1 |
| 9 | GRAS Substances显示文摘 | Bernard L Oser R A Ford | 1998 | Food Technology1998，52，9： | 1 |
| 10 | Genetic improvement in the yield of winter:afurther evaluation 显示文摘 | AUSTIN R B FORD M A MORGAN C L | 1989 | J Agric Sci1989，112，： | 1 |
| 11 | The role of the surgeon in the evolution of flexible endoscopy显示文摘 | Morgenthal C B Richards W O Dunkin B J Forde K A Vitale G Lin E | 2007 | Surg Endosc2007，21，6： | 1 |
| 12 | Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans 显示文摘 | Castillo U F Strobel G A Ford E J | 2002 | Microbiology2002，148，9： | 1 |
| 13 | Munumbicins, wide spectrum antibiotics produced by Streptomyces endophytic on Kennedia nigriscans显示文摘 | CASTILLO U F STROBEL G A FORD E J | 2002 | Microbiology2002，148，： | 1 |
| 14 | Neonicotinoid insecticides induce salicylate-associated plant defense responses 显示文摘 | FORD K A CASIDA J E CI-{ANDRAN D | 2010 | PNAS2010，107，17： | 1 |
| 15 | Evaluation of the oral subchronic tox-icity of HHCB(1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-g-2-benzopyran)in the rat显示文摘 | Api A M Ford R A | 1999 | Toxi-cology Letters1999，111，12： | 1 |
| 16 | A long-wavelength fluorescent chemodosimeter selective for Cu(Ⅱ)ion in water显示文摘 | Dujols V Ford F Czarnik A W | 1997 | Journal of the American Chemical Society1997，119，31： | 1 |
| 17 | Acin: a 1, 3-di- hydroisobenzofuran from Pestalotiopsis microspora possessing an- tioxidant and antimycotic activities显示文摘 | Harper J K Ford E J Strobe1 G A | 2003 | Tetrahedron2003，59，： | 1 |
| 18 | Neural processes associated with antisaccade task performance investigated with event- related fMRI显示文摘 | FORD K A GOLTZ H C BROWN M R G | 2005 | Journal of Neurophysiology2005，94，1： | 1 |
| 19 | Estimation,variation and importance of leaf curvature in Zea mays hybrids显示文摘 | Ford ED Cocke A Horton L Fellner M | 2008 | Agr Forest Meteorol2008，148，： | 1 |
| 20 | Assessing variation in the radial profile of sap flux density in Pinus species and its effect on daily water use显示文摘 | Ford C Mcguire M A Mitchell R J | 2004 | Tree Physiology2004，24，3： | 1 |
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