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| 1 | Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion显示文摘(MALAT1 ) 联系转移的肺腺癌抄本 1 被建议是一长(7 kb ) 非编码的 RNA。MALAT1 是在许多人的癌的 overexpressed,但是它的功能仍然保持未知。在人的颈的癌症前进调查 MALAT1 的角色,我们设计了并且使用了短发卡 RNA 在 CaSki 房间禁止 MALAT1 表示并且在房间增长和侵略上验证了它的效果。在基因表示的变化被反向的 transcriptasepolymerase 链反应分析。我们的数据证明 MALAT1 通过基因表示的规定涉及颈的癌症房间生长,房间周期前进,和侵略,例如 caspase-3, -8, Bax, Bcl-2,和 Bcl-xL,建议 MALAT1 能有在颈的癌症生物学的重要含意。我们的调查结果在颈的癌症前进说明 MALAT1 的生物意义并且提供 MALAT1 可以在人的颈的癌症的预防作为一个治疗学的目标服务的新奇证据。 | Fengjie Guo Yalin Li Yan Liu Jiajia Wang Yuehui Li Guancheng Li | 2010 | Acta Biochimica et Biophysica Sinica2010，42，3： | 89 |
| 2 | Correlation between lower gastrointestinal tract symptoms and quality of life in patients with stable chronic obstructive pulmonary disease显示文摘OBJECTIVE:To explore correlations between the symptoms of constipation and abdominal distention and severity of chronic obstructive pulmonary disease(COPD)in patients with stable disease.METHODS:We studied 191 patients with stable COPD(according to defined criteria)in this cross-sectional study from four three-level class A Chinese medicine hospitals in China.We built an Epidata 3.0 database and performed statistical analysis with SPSS,version 17.0.We analyzed correlations between the frequency of lower gastrointestinal tract symptoms(constipation and abdominal distention)and scores for major pulmonary symptoms(cough,sputum and wheezing)based on the St.George's Respiratory Questionnaire(SGRQ),6-minute walking distance(6MWD)and frequency of acute exacerbations of COPD(AECOPD).RESULTS:In addition to their pulmonary symptoms,39.79%and 40.31%of study patients withstable COPD reported constipation and abdominal distention,respectively.Scores for major pulmonary symptoms(cough,sputum and wheezing),AECOPD and SGRQ values in patients with constipation and abdominal distention were significantly greater,and the 6MWD markedly shorter,than in those without them.According to Pearson's correlation analysis,there were strong correlations between these lower gastrointestinal tract symptoms and scores for pulmonary symptoms,SGRQ,6MWD and AECOPD.CONCLUSION:Lower gastrointestinal tract symptoms such as constipation and abdominal distention can adversely affect pulmonary symptoms,frequency of acute exacerbations and quality of life in patients with stable COPD. | Yan Sun Fengjie Zheng Yuhang Li Ruohan Wu Yuchao Liu Miao Liu Jinchao Zhang Kuo Gao | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 10 |
| 3 | Effect of yellow rice wine on anti-aging ability in aged mice induced by D-galactose显示文摘The present study is focused on investigation of the health protective effect of yellow rice wine(YRW)in mice and the potential underlying mechanism.Symptoms of aging were induced in mice by using Dgalactose(D-gal),and different doses of YRW(4,8,and 12 mL/kg BW)were orally administrated to D-galtreated mice for a period of six weeks.The in vivo data obtained in the present study preliminary indicated that YRW markedly increased the activity of antioxidant enzymes and reduced the concentration of MDA both in the brain and liver.Furthermore,a forced swim test showed that moderate intake of YRW(8 mL/kg BW)significantly decreased the duration of immobility,reduced the blood content of urea nitrogen and lactic acid,and increased hepatic glycogen storage.Besides,results from the Morris water maze test suggested that YRW significantly reversed cognitive impairment and also alleviated neuroapoptosis in the experimental mice by regulating the gene expressions of Bax/Bcl-2 and caspase-3.The above results indicated YRW has a potential anti-aging effect in mice and provided us certain molecular evidence for this action. | Rong Liu Zukang Fu Fengjie Zhang Qingzhong Mao Chunguang Luan Xinglin Han Jie Xue Deliang Wang Si Qin Feike Hao | 2020 | Food Science and Human Wellness2020，9，2： | 8 |
| 4 | Development and validation of an analytical method for detecting chlorantraniliprole residues in fresh tea leaves显示文摘An efficient method using multiwalled carbon nanotubes(MWCNTs)as dispersive solid-phase extraction sorbent was established for determining chlorantraniliprole residues in fresh tea leaves,which are known to be a troublesome matrix containing abundant pigments,via gas chromatography with an electron capture detector.Acetonitrile was used as the extraction solvent,with sodium chloride enhancing the analyte partition in the organic phase.The optimal mixture of MWCNTs and primary secondary amine(PSA)was based on the distribution of the target analyte recovery and on the clean-up efficiency;while matrix-matched calibration was recommended to combat the matrix effect.Mean recoveries of 95.2%–108.8%were obtained with intraday and interday precisions of less than 7.9%and 10.3%,respectively.Good linearity was observed for concentrations of 0.02–1.0 mg/kg with a correlation coefficient of 0.9984.The limits of detection and quantification were 0.005 mg/kg and 0.02 mg/kg,respectively.The method was employed to investigate the dissipation dynamics of chlorantraniliprole in fresh tea leaves with real field samples.Consequently,the dissipation rates of chlorantraniliprole in fresh tea leaves followed pseudo-first-order kinetics with a half-life of 1.9 d,and the average chlorantraniliprole residue content was below 0.02 mg/kg with a harvest withholding period of 14 d. | Tengfei Liu Minghui Dong Fengjie Zhou Daifeng Yang Xueming Zhang | 2019 | Food Science and Human Wellness2019，8，4： | 5 |
| 5 | Effects of Rat Cytomegalovirus on the Nervous System of the Early Rat Embryo显示文摘The purpose of the study was to investigate the impact of rat cytomegalovirus(RCMV) infection on the development of the nervous system in rat embryos,and to evaluate the involvement of Wnt signaling pathway key molecules and the downstream gene neurogenin 1(Ngn1) in RCMV infected neural stem cells(NSCs).Infection and control groups were established,each containing 20 pregnant Wistar rats.Rats in the infection group were inoculated with RCMV by intraperitoneal injection on the first day of pregnancy.Rat E20 embryos were taken to evaluate the teratogenic rate.NSCs were isolated from E13 embryos,and maintained in vitro.We found:1) Poor fetal development was found in the infection group with low survival and high malformation rates.2) The proliferation and differentiation of NSCs were affected.In the infection group,NSCs proliferated more slowly and had a lower neurosphere formation rate than the control.The differentiation ratio from NSCs to neurons and glial cells was significantly different from that of the control,showed by immunofluorescence staining.3) Ngn1 mRNA expression and the nuclear β-catenin protein level were significantly lower than the control on day 2 when NSCs differentiated.4) The Morris water maze test was performed on 4-week pups,and the infected rats were found worse in learning and memory ability.In a summary,RCMV infection caused abnormalities in the rat embryonic nervous system,significantly inhibited NSC proliferation and differentiation,and inhibited the expression of key molecules in the Wnt/β-catenin signaling pathway so as to affect NSCs differentiation.This may be an important mechanism by which RCMV causes embryonic nervous system abnormalities. | Xiuning Sun YingJun Guan Fengjie Li Xutong Li Xiaowen Wang Zhiyu Guan Kai Sheng Li Yu Zhijun Liu | 2012 | Virologica Sinica2012，27，4： | 4 |
| 6 | Porcine intestinal antimicrobial peptide as an in-feed antibiotic alternative improves intestinal digestion and immunity by shaping the gut microbiota in weaned piglets显示文摘Antibiotic resistance of pathogens,which is caused by the abuse of in-feed antibiotics,threatens the sustainable development of livestock production.The present study aimed to investigate the efficiency of porcine intestinal antimicrobial peptide(PIAP)as an alternative to in-feed antibiotics in terms of growth performance,intestinal morphology,digestive enzymes and immunity,and microbiota community of the post-weaning piglets.A total of 204 piglets(Duroc×Landrace×Yorkshire,weaned at 28 d age)with a similar body weight of 7.97±1.04 kg were randomly allocated to 4 groups(51 piglets per group):(1)control group:basal diet;(2)AB group:antibiotic,basal diet+chlortetracycline(1000 mg/kg from d 1 to24;500 mg/kg from d 25 to 37);(3)P1 group:basal diet+a relatively low dose of PIAP(400 mg/kg from d 1 to 24;300 mg/kg from d 25 to 37);(4)P2 group,basal diet+a relatively high dose of PIAP(600 mg/kg from d 1 to 24;500 mg/kg from d 25 to 37).The results showed that serum indicators of hepatocyte damage and relative organ weight were not affected by these treatments(P>0.05).Compared with the AB treatment,the P1 treatment remarkably decreased jejunal crypt depth and increased jejunal and ileal villus height:crypt depth ratio(P<0.05).The values of jejunal maltase,lactase,sucrase,intestinal alkaline phosphatase,and secretory immunoglobulin A(SIg A)in the P1 group were sharply increased compared with those in the control and P2 groups(P<0.05).Compared with the control group,the P1 group decreased serum concentrations of D-lactate,diamine oxidase,and endotoxin(P<0.05),and increased the abundance of Lactobacillus reuteri(P<0.05)in the colonic feces.Furthermore,there was a positive correlation between the abundance of L.reuteri and the concentrations of maltase,lactase,sucrase,and SIg A(P<0.05).Collectively,dietary supplementation with a relatively low dose of PIAP(400 mg/kg from d 1 to 24;300 mg/kg from d 25 to 37)demonstrates beneficial effects on intestinal morphology,digestive enzymes,immunity,and permeability by shaping the gut microbiota composition in weaned piglets.This study will provide a valuable reference for using PIAP as an in-feed antibiotic alternative in swine production. | Fengjie Ji Huansheng Yang Qiye Wang Jianzhong Li Hanlin Zhou Shengmin Liu | 2023 | Animal Nutrition2023，，3： | 3 |
| 7 | Formation Mechanism of Ground Fissures Originated from the Hanging Wall of Normal Fault:A Case in Fen-Wei Basin,China显示文摘This paper takes Fen-Wei Basin(FWB)as a case to study the ground fissures controlled by normal fault.Based on the field investigation,geophysical exploration,drilling,GNSS data and numerical calculation,the characteristics and mechanism of ground fissures originated from the hanging wall of normal faults are revealed.The results show that the distribution of ground fissures in the hanging wall and heading wall of the active faults is not uniform.Ground fissures are mostly distributed in the hanging wall of active faults and show a linear distribution on the surface,their strike is consistent with the fault,mainly characterized by vertical offset and horizontal tension.Ground fissures destroy the farmland and building foundation through which they pass and cause the rupture or displacement.In profile section,the ground fissure shows the characteristics of normal faults and dislocates the strata,and is connected with the underlying faults.Numerical analysis shows that the vertical displacement of normal fault activity in hanging wall is much larger than that in heading wall,which is the reason that tectonic ground fissures mainly originate from hanging wall.The range of dangerous area of ground fissures is controlled by the depth of fault,the strength of the ground fissures disaster is mainly controlled by the activity of fault.The formation of the ground fissures originated from the hanging wall of the fault experienced three stages:the main fault activity stage,the secondary fault activity stage and the fissure formation stage. | Zhijie Jia Jianbing Peng Quanzhong Lu Jianwei Qiao Feiyong Wang Mingdong Zang Yang Liu Junyan Zhao Fengji Zhu | 2022 | Journal of Earth Science2022，33，2： | 2 |
| 8 | Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula显示文摘Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis(AD).Methods: Sixty specific-pathogen free male BALB/c mice were randomly divided into the control group,model group, whole formula group(WF), exterior-releasing formula group(ERF), interior-clearing formula group(ICF), and positive control group(PC). A mouse model of AD was established using the semiantigen 2,4-dinitrofluorobenzene induction method. The lesion scores, transepidermal water loss and p H, and skin histopathology of mice in each group were observed. The expressions of filaggrin, loricrin,and involucrin were detected by the streptavidin peroxidase immunohistochemical method and western blotting, and their mRNA expressions were detected by quantitative polymerase chain reaction.Results: Mice in the WF, ERF, ICF, and PC groups showed reduced skin lesion performance, improved histopathology, decreased skin lesion score, transepidermal water loss and pH, and upregulated expressions of proteins including filaggrin, loricrin, and involucrin, and their mRNAs. The most obvious regulatory effect was observed in the WF group, followed by the ICF, ERF, and PC groups, accordingly.Conclusions: Mahuang Lianqiao Chixiaodou decoction and its disassembled formula can improve the skin barrier function in a mouse model of AD by upregulating filaggrin, loricrin, and involucrin, and their mRNA expressions, and the most optimal effect was noted in the WF group, followed by the ICF and ERF groups, which suggests that the effect of clearing heat and resolving dampness in improving the skin barrier function of AD is more obvious and is one of the key treatments for AD. | Jingang Liu Yan Sun Huimin Yuan Yuda Li Jing Feng Yushan Gao Yang Tang Shujing Zhang Hang Wang Fengjie Zheng | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，4： | 2 |
| 9 | Sugarcane bagasse dietary fiber as an adjuvant therapy for stable chronic obstructive pulmonary disease:a four-center,randomized,double-blind,placebo-controlled study显示文摘OBJECTIVE:To evaluate the efficacy and safety of sugarcane bagasse dietary fiber as an adjuvant therapy for improving quality of life in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:This was a multicenter,randomized,double-blind,placebo-controlled trial.A total of196 participants were randomized into a trial group(treated with 6 g/day sugarcane bagasse plus conventional treatment,n = 98) and a control group(treated with placebo plus conventional treatment,n = 98).All efficacy analyses were performed according to the intention-to-treat(ITT) principle.A per-protocol analysis set(PPS) was used to analyze the cases that completed the clinical trial with good compliance.The trial period was 30 days,with a 6-month follow-up.Pre-and post-treatmentpulmonary symptom scores(cough,sputum,wheezing,and dyspnea) were recorded for both groups.The St.George's Respiratory Questionnaire(SGRQ) and the modified Medical Research Council(m MRC) dyspnea scale were assessed before treatment and at the end of the 6-month follow-up.RESULTS:The ITT population was 178 and the PPS population was 166.Post-treatment pulmonary clinical symptoms and severity of dyspnea(m MRC and SGRQ evaluation) were significantly improved in both the trial group and the control group(ITT and PPS:P < 0.05).However,there was no statistical difference between the two groups in post-treatment pulmonary symptoms and m MRC.There was a greater reduction in the SGRQ subscales of activity,effect and total score in the trial group compared with the control group(ITT and PPS:P < 0.01).There was no statistical difference in pre-and post-treatment safety variables in either group.CONCLUSION:Sugarcane bagasse combined with conventional treatment improved quality of life in patients with stable COPD.Sugarcane bagasse appears to be a safe herbal medicine with potential for treating patients with stable COPD when taken orally as an adjuvant therapy. | Liu Miao Zheng Fengjie Ni Lei Sun Yan Wu Ruohan Zhang Tianyu Zhang Jinchao Zhong Xianggen Li Yuhang | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 2 |
| 10 | Olfactory and gustatory dysfunctions of COVID-19 patients in China:A multicenter study显示文摘Introduction:With the spread of the epidemic worldwide,an increasing number of doctors abroad have observed the following atypical symptoms of coronavirus disease 2019(COVID-19):olfactory or taste disorders.Therefore,clarifying the incidence and clinical characteristics of olfactory and taste disorders in Chinese COVID-19 patients is of great significance and urgency.Materials and Methods:A retrospective study was conducted,which included 229 severe acute respiratory syndrome coronavirus 2 confirmed patients,through face-to-face interviews and telephone follow-up.Following the completion of questionnaires,the patients participating in the study,were categorized according to the degree of olfactory and taste disorders experienced,and the proportion of each clinical type of patient with olfactory and taste disorders and the time when symptoms appeared were recorded.Results:Among the 229 patients,31(13.54%)had olfactory dysfunction,and 44(19.21%)had gustatory dysfunction.For the patients with olfactory dysfunction,6(19.35%)developed severe disease and became critically ill.Olfactory dysfunction appeared before the other symptoms in 21.43%of cases.The proportion of females with olfactory and gustatory dysfunction was higher than that of males(P<0.001).Conclusions:The incidence of olfactory and gustatory dysfunction was much lower than that reported abroad;the prognosis of patients with olfactory dysfunction is relatively favorable;olfactory and gustatory dysfunction can be used as a sign for early screening;females are more prone to olfactory and gustatory dysfunction. | Jianhui Li Yi Sun Enqiang Qin Hu Yuan Mingbo Liu Wenqi Yi Zhu Chen Chengcheng Huang Fengjie Zhou Ruiyao Chen Leibo Zhang Ning Yu Qiong Liu Xuejun Zhou Jingjing He Boyu Li Fusheng Wang Changliang Yang Shiming Yang | 2022 | World Journal of Otorhinolaryngology-Head and Neck Surgery2022，8，4： | 2 |
| 11 | Asymptotic behavior for a reaction-diffusion equation with inner absorption and boundary flux显示文摘 | ZHENG Sining LI Fengjie LIU Bingchen | 2006 | Applied Mathematics Letters2006，19，： | 1 |
| 12 | Non-simultaneous blow-up and blow-up rates for reaction-diffusion equa- tions显示文摘 | LIU Bingchcn LI Fengjie | 2012 | Nonlinear Analysis: Real World Applications2012，13，： | 1 |
| 13 | Root foraging for zinc and cadmium requirement in the Zn/Cd hyperaccumulator plant Sedum alfredii显示文摘 | LIU Fengjie TANG Yetao DU Ruijun | 2010 | Plant Soil2010，327，1： | 1 |
| 14 | Degenerate bifurcations of nontwisted heterodimensional cycles with codimension 3 显示文摘 | Liu Dan Geng Fengjie Zhu Deming | 2008 | Nonl Anal2008，68，： | 1 |
| 15 | Identification of HTA as a novel-specific marker for human hepatocellular carcinoma显示文摘 | Yan Liu Yuehui Li Fengjie Guo Miao Dai Jiajia Wang Jinyue Hu Guancheng Li | 2010 | Journal of Cancer Research and Clinical Oncology2010，，8： | 1 |
| 16 | The Chemopreventive Effect of Tamoxifen Combined with Celecoxib on DMBA chemically-Induced Breast Cancer显示文摘Objective: To investigate the chemopreventive effect of tamoxifen combined with a COX-2 selective inhibitor, celecoxib, on breast cancer in rats chemically induced by 7,12-dimethylben(a)anthracene (DMBA). Methods:DMBA was irrigated into the stomaches of SD female rats to build breast cancer model. A total of 120 rats were divided into four groups: control group, tamoxifen group, celecoxib group and combined group. The incidence rate, latent period, number and volume of breast cancer were detected and analyzed. Results:The tumor incidence rate of tamoxifen group (48.15%, 13/27) and celecoxib group (50.00%, 14/28) were lower than that of control group (85.71%, 24/28), but higher than that of combined group (21.43%, 6/28). The tumor's latent period of tamoxifen group (97.54±1.85 d) and celecoxib group (96.79±2.89 d) were longer than that of control group (89.50±5.99 d), but shorter than that of combined group (103.67±3.39 d). The average tumor number of tamoxifen group (1.77±0.73) and celecoxib group (1.71±0.61) were less than that of control group (3.50±1.62), but more than that of combined group (1.17±0.42). The average tumor volume of tamoxifen group (1.78±0.71 cm3) and celecoxib group (2.05±1.04 cm3) were smaller than that of control group (6.42±3.96 cm3), but bigger than that of combined group (0.71±0.96 cm3) (P < 0.05 respectively). Conclusion:Celecoxib and tamoxifen are effective drugs in preventing the occurrence of rat breast cancer chemically induced by DMBA. Furthermore, combination of them has better chemopreventive effect. | Xiaoxu Liu Huafeng Kang Xijing Wang Zhijun Dai Fengjie Xue Xinghuan Xue | 2007 | Journal of Nanjing Medical University2007，21，2： | 1 |
| 17 | Improvement of xylanase production by penicillium oxalicum ZH-30 using response surface methodology显示文摘 | Li Yin Cui Fengjie Liu Zhiqiang | 2007 | Enzyme and Microbial Technology2007，，40： | 1 |
| 18 | Application of Plackett–Burman experimental design and Doehlert design to evaluate nutritional requirements for xylanase production by Alternaria mali ND-16显示文摘 | Yin Li Zhiqiang Liu Fengjie Cui Zhisheng Liu Hui Zhao | 2007 | Applied Microbiology and Biotechnology2007，，2： | 1 |
| 19 | Effects of fufang yimucao oral liquid on acute ache model mice显示文摘BACKGROUND: Fufang yimucao oral liquid has markedly effects on ameliorating circulation,restraining uterine constriction induced by oxytocin,alleviating dysmenorrhea,as a traditional medicine on promoting blood circulation by removing blood stasis,yimucao could ameliorate abnormal hemorrheological when hemorrhagic shock happens,enhance the hemoperfusion of organs and actively react on the result of hemorrhagic shock. OBJECTIVE: To investigate the abirritation of fufang yimucao oral liquid on pain model mice induced by hot board method and acetic acid twist body method and dysmenorrhea model mice induced by estradiol. DESIGN: Entirely randomly grouping and control experiment. SETTING: Pharmacological Laboratory,Henan College of Traditional Chinese Medicine. MATERIALS: A total of 200 female Kunming genus mice of grade 2 and weighing 18-21 g were collected. Fufang yimucao oral liquid,mainly consist of yimucao,danggui,chuanxiong,muxiang,and so on,was produced by Henan Joyline&Joysun Pharmaceutical Stock Co.,Ltd. (batch number: 050701); yimucao oral liquid was produced by Shangqiu Lvyuan Pharmaceutical Co.,Ltd. (batch number: 050108); estradiol slice by Shanghai Xinyi Kangjie Pharmaceutical Co.,Ltd. (batch number: 050301); YSL-6A intelligence hot plate instrument by Shandong Equipments Station of the Medical Science. METHODS: The experiment was carried out in the Animal Experiment Center of the Henan College of Traditional Chinese Medicine from August to November 2005. The high-,middle-and low-dosage fufang yimucao oral liquid in the experiment was 1,0.5 and 0.25 in volume fraction,respectively,and yimucao oral liquid was 0.5. ① Among 80 mice,60 mice were eligible in pain threshold tested by hot plate,and randomly dividing into 5 groups with 12 in each group. Mice in the high-,middle-and low-dose fufang yimucao oral liquid groups were perfused with 1 mL,0.5 mL and 0.25 mL/mL fufang yimucao,and mice in the yimucao group and saline group were perfused with the same volume yimucao oral liquid and saline,respectively,once a day for 3 successive days. Half an hour and one hour after administration for the last time,the range of pain was tested in hot plate and the increasing numerical value was counted. ② Another 60 mice were randomly divided into 5 groups. The grouping ways,numbers of animal and administration were as the same as those mentioned above. Forty minutes after administration for the last time,mice were given the celiac injecting with the fresh acetic acid,then observed and registered the delitescence of turned body and the times of turning in 10 minutes. ③ The rest of 60 mice were randomly divided into 6 groups with 10 in each group. The five groups were divided as the same as mentioned above,and the last group was the blank control group. Mice in the 5 former groups were given synestrin tablets CMC suspension with the dose of 2 mg/kg,0.1 g/L and 0.2 mL/10 g once a day for 12 successive days. Ten days later,mice were administrated as the same ways and dosage mentioned above. Mice in blank control group were perfused with the same volume of saline. Two days after modeling and 40 minutes after administration,mice were injected with oxytocin to observe the latent period and the frequency of twisting reaction in 10 minutes. MAIN OUTCOME MEASURES: Effect of fufang yimucao oral liquid on mice pain model induced by hot board method,twisting body response induced by acetic acid and mice dysmenorrhea model. RESULTS: ① Effect of fufang yimucao oral liquid on mice pain model induced by hot board: Thirty minutes after administration,the pain threshold of yimucao oral liquid group and high-,middle-and low-dose fufang yimucao oral liquid groups were respectively (25.42±2.10),(22.40±3.42),(25.24±2.51) and (19.80 ±2.00) s,which were markedly higher than saline group (17.98±1.68) s,P < 0.05-0.01. Sixty minutes after administration,the pain threshold of yimucao oral liquid group and high-,middle-and low-dose fufang yimucao oral liquid groups were respectively (27.42±2.17),(23.83±2.66),(27.64±2.64) and (21.51±2.41) s,which were markedly higher than saline group (17.8±1.75) s,P < 0.01. ② Effect of fufang yimucao oral liquid on twisting body response induced by celiac injecting acetic acid: The twisting body latent period of yimucao oral liquid group and high-,middle-and low-dose fufang yimucao oral liquid groups were respectively (2.43±0.19),(2.09±0.20),(2.60±0.14) and (1.85±0.35) s,which were markedly higher than saline group (1.45±0.22) s,P < 0.01. The twisting body times in 10 minutes of yimucao oral liquid group and high-,middle-and low-dose fufang yimucao oral liquid groups were respectively (14.8±4.0),(15.8± 3.5),(12.2±3.7) and (18.7±3.3) times,which were markedly lower than saline group (25.0±5.0) times,P < 0.01. ③ Effect of fufang yimucao oral liquid on mice dysmenorrhea model: After injecting estradiol,the twisting body latent period of yimucao oral liquid group and high-,middle-and low-dose fufang yimucao oral liquid groups were respectively (61.8±20.8),(105.8±29.8),(78.9±14.0) and (71.9±20.0) s,which were higher than the saline group (31.6±14.71) s,P < 0.01. The twisting body times in 10 minutes of yimucao oral liquid group and high-,middle-and low-dose fufang yimucao oral liquid groups were respectively (18.1±4.2),(9.5±2.8),(16.2±3.5) and (19.9±4.6) times,which were lower than the saline group (28.5±4.7) times,P < 0.01. CONCLUSION: Fufang yimucao oral liquid has a good effect on abirritation,condignly as yimucao oral liquid,besides it does not have obvious dependent effect. | Fengjie Wang Mingsan Miao Yulin Zhang Jingjing Shi Yalei Yang Huili Liu | 2007 | Neural Regeneration Research2007，2，6： | 1 |
| 20 | Simultaneous and non-simultaneous blow-up for a cross-coupled parabolic system显示文摘 | Sining ZHENG Bingchen LIU Fengjie LI | | 0，，01： | 1 |
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