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| 1 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 2 | International experts consensus guidelines on robotic liver resection in 2023显示文摘The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still exist.Based on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice.The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation group.According to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were generated.Among them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM results.This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future. | Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau | 2023 | World Journal of Gastroenterology2023，29，32： | 2 |
| 3 | Computational fluid dynamic analysis and design optimization of jet pumps 显示文摘 | Fan J Eves J Thompson H M Toropov V V Kapur N Copley D Mincher A | 2011 | Computers Fluids2011，46，： | 1 |
| 4 | Significance of immune cell function monitoring in renal transplanta- tion after Thymoglobulin induction therapy 显示文摘 | Serban G Whittaker V Fan J | 2009 | Hum Immunol2009，70，11： | 1 |
| 5 | Measuring Education Inequality: Gini Coefficient of Education for 140 countries显示文摘 | Thomas V Yah Wang and Xibo Fan | 2003 | Journal of Education Planning and Administration2003，17，1： | 1 |
| 6 | Acute alterations in growth hormone-insulin-like growth factor axis in humans injected with endotoxin显示文摘 | LANG C H POLLARD V FAN J | 1997 | Am J Physiol1997，273，： | 1 |
| 7 | 查看详情显示文摘 | Fan W Snyder M A Kumar S Lee P S Yoo W C McCormick A V Penn R L Stein A Tsapatsis M | | 0，，： | 1 |
| 8 | Experimental and numerical investigations of flame pattern formation in a radial microchannel显示文摘 | Fan A W Minaev S Sereshchenko E V | | 0，，02： | 1 |
| 9 | The adoption and design methodologies of component-based enterprise systems显示文摘 | Stallaert J Whinston V B | 2000 | European Journal of Information Systems2000，9，1： | 1 |
| 10 | Changing patterns of strabismus: a decade of experience in Hong Kong显示文摘 | C B O Yu f HongkongD S P Fan V W Y Wong | 2002 | Br J Ophthalmol2002，86，： | 1 |
| 11 | Li-Cyeling properties of molten salt method prepared nano/submierometer and mi- crometer-sized CuO for lithium batteries 显示文摘 | Reddy M V Cai Y Fan J | 2013 | ACS Appl Mater Interfaees2013，5，10： | 1 |
| 12 | Automa tedtarget tracking and recognition using coupled view and identity manifolds for shape representation 显示文摘 | Venkataraman V Fan G Yu L | 2011 | Advances in Signal Processing2011，124，： | 1 |
| 13 | Effective therapy for nephritis in (NZB × NZW) F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F显示文摘 | Tao X Fan F Hoffmann V | 2008 | Arthritis Rheum2008，58，6： | 1 |
| 14 | DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma显示文摘 | Kim S K Fan Y Papadimitrakopoulou V | 1996 | Cancer Res1996，56，11： | 1 |
| 15 | Radiation induced temporal lobe necrosis 显示文摘 | Chong V F Fan Y F | 1997 | AJNR Am J Neuroradiol1997，18，4： | 1 |
| 16 | Angiogenesis in a delayed revascularization model is accelerated by angiogenic oligosaccharides of hyaluronan显示文摘 | Lees V C Fan T P West D C | 1995 | Lab Invest1995，73，： | 1 |
| 17 | Probabilistic power flow studies for transmission systems with photovoltaic generation using cumulants显示文摘 | Fan M ViRal V Heydt G T | 2012 | IEEE Transactions on Power Systems2012，27，4： | 1 |
| 18 | Optimized asym-metrical tangent phase mask to obtain defocus in-variant modulation transfer function in incoherentimaging systems 显示文摘 | LE V N CHEN S Q FAN Z G | 2014 | Opt Lett2014，39，7： | 1 |
| 19 | Nitrification and mass balance with a membrane bioreaetor for municipal wastewater treatment 显示文摘 | Fan X J Urbain V Qian Y | 1996 | Water Sci Technol1996，34，12： | 1 |
| 20 | Costs of pulmonary rehabilitation and predictors of adherence in the National Emphysema Treatment Trial 显示文摘 | Fan V S Giardino N D Blough D K | 2008 | COPD2008，5，2： | 1 |
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