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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Growth hormone receptor is a target for presenilin-dependent gam- ma-secretase cleavage 显示文摘 | Cowan J W Wang X D Guan R He K Jiang J Baumann G Black R A Wolfe M S Frank S J | 2005 | J Biol Chem2005，280，19： | 1 |
| 3 | Photodynamic therapy for condylomata acuminata with local application of 5-aminolivulinic acid显示文摘 | Frank R G Bos J D | 1996 | Genitourinary Med1996，72，1： | 1 |
| 4 | Evolutionary relationships of cultivated psychrophilicand barophilic deep-sea bacteria显示文摘 | Delong E F Franks D G Yayanos A A | 1997 | Appl Environ Microbiol1997，63，： | 1 |
| 5 | Manufacturing DNA microarrays of high spot homogeneity and reduced background signal显示文摘 | Frank D Suaanne G Markus B | 2001 | Nucleic Acids Res2001，29，7： | 1 |
| 6 | Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease显示文摘 | Jiang Changtao Xie Cen Li Fei Zhang Limin Nichols Robert G Krausz Kristopher W Cai Jingwei Qi Yunpeng Fang Zhong-Ze Takahashi Shogo Tanaka Naoki Desai Dhimant Amin Shantu G Albert Istvan Patterson Andrew D Gonzalez Frank J | 2015 | Journal of Clinical Investigation2015，，1： | 1 |
| 7 | HfO2 and Al2O3 gate dielectrics on GaAs grown by atomic layer deposition显示文摘 | Frank M M Wilk G D Starodub D | 2005 | Appl Phys Lett2005，86，15： | 1 |
| 8 | Evolutionary relationships of cultivated psychrophilic and bar- ophilic deep-sea bacteria显示文摘 | DELONG E F FRANKS D G YAYANOS A A | 1997 | Appl Enviorn Mierobiol1997，63，5： | 1 |
| 9 | Linking Organizational Learn-ing and Customer Capital Through an Ambidexterity Context:AnEmpirical Investigation in SMEs显示文摘 | Juan G Cegarra-Navarro Frank D | 2007 | Int J of Human Resource Man-agement2007，，17： | 1 |
| 10 | Evolutionary relationships of cultivated psychrophilic and barophilic deep sea bacteria 显示文摘 | Delong E F Franks D G Yayanos A A | 1997 | Applied and Environmental Microbiology1997，63，5： | 1 |
| 11 | Impacts of mixed use and density on utilization of three modes of travel: single occupant vehicle, transit, and walking 显示文摘 | Frank L D Pivo G | 1994 | Transportation ResearchRecord1994，1466，： | 1 |
| 12 | The product of the ybdE gene of the Escherichia coli chromosome is involved in detoxification of silver ions 显示文摘 | FRANKE S GRASS G NIES D H | 2001 | Microbiology2001，147，4： | 1 |
| 13 | The molecular basis for differential dioxin sensitivity in birds:Role of the aryl hydrocarbon receptor显示文摘 | Karchner S I Franks D G Kennedy S W | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，103，16： | 1 |
| 14 | Impacts of mixed use and density on utilization of three modes of travel: single-occupant vehicle, transit, and walking显示文摘 | Frank L D Pivo G | 1994 | Transportation research record1994，，1466： | 1 |
| 15 | Evolutionary relationships of cultivate psy-chrophilic and barophilic deep-sea bacteria显示文摘 | Delong E F Franks D G Yayanos A A | 1997 | Appl Environ Microbiol1997，63，： | 1 |
| 16 | Reaction kinetics of the denaturation of whey protein in milk显示文摘 | Frank D Heinz G K | 1988 | Journal of food Science1988，53，1： | 1 |
| 17 | Post - ERCP pancreatitis and its pre- vention显示文摘 | FRANK C D ADLER D G | 2006 | Nat Clin Pract Gastroenterol Hepatol2006，3，12： | 1 |
| 18 | Kunashir(Kuriles)Oak 400-year reconstruction of temperature and relation to the Pacific Decadal Oscillation显示文摘 | Jacoby G Solomina O Frank D | 2004 | Palaeognography Palaeoclimatology Palaeoecology2004，209，： | 1 |
| 19 | Autonomous Driving Goes Downtown显示文摘 | Franke U Gavrila D G(o)rzig S | 1998 | IEEE Intelligent Systems & Their Applications1998，13，6： | 1 |
| 20 | Radiofrequeney thermal ablation= computer analysis of the size of the thermal injury created by overlapping ablations显示文摘 | Dodd G D 3rd Frank M S Aribandi M Chopra S Chintapalli K N | 2001 | AJR Am J Roentgenol2001，177，： | 1 |
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