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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Introduction to a system for distributed databases (SDD-1)显示文摘 | Rothnie Jr J B Bernstein P A Fox S | 1980 | ACM Transactions on Database Systems (TODS)1980，5，1： | 1 |
| 3 | Radiation dose reduction for CT lung cancer screening using ASIR and MBIR: a phantom study显示文摘 | Mathieu K B Ai H Fox P S | 2014 | J Appl Clin Med Phys2014，15，2： | 1 |
| 4 | Potential clinical rele-vance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines显示文摘 | FOX B P TABONE C KANDPAL R P | | 0，，04： | 1 |
| 5 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 6 | A combined approach to improving large-scale production of tobacco etch virus protease显示文摘 | Blommel P G Fox B G | 2007 | Protein Expr Purif2007，55，1： | 1 |
| 7 | Trends in Biotechnology,显示文摘 | Fox D B Moody T S | 2001 | 19:292001，19，： | 1 |
| 8 | Algorithm 659: Implementing Sobol's quasirandom sequence generator 显示文摘 | Bratley P Fox B | 1988 | ACM Trans Math Software1988，14，1： | 1 |
| 9 | Abyssal anti-dunes显示文摘 | Fox P J Heezen B C Harian A M | 1968 | Nature1968，220，： | 1 |
| 10 | Accelerated Ripening of Cheddar Cheese at Elevated Temperatures显示文摘 | FORKERTSMA B FOX P F MCSWEENEY P L H | 1999 | Dairy Journal1999，6，： | 1 |
| 11 | Traumatic aneurysms of the superficial temporal artery: case report 显示文摘 | FOX J T CORDTS P R GWINN B C 2ND | 1994 | J Trauma1994，36，4： | 1 |
| 12 | Effects of soil type and effluent pre-treatment on soil aquifer Ixeatment显示文摘 | Kopchynski T Fox P Alsmaldi B | 1996 | Water Sci & Teehnol1996，34，1： | 1 |
| 13 | The afterglow of GRB 050709 and the nature of the short-hard γ-ray bursts显示文摘 | FOX D B FRAIL D A PRICE P A | 2005 | Nature2005，437，： | 1 |
| 14 | Quantification and localization of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection显示文摘 | Ward S M Fox B C Brown P J | 2007 | J Heptol2007，47，： | 1 |
| 15 | Dissecting intramural haematoma of the oesophagus显示文摘 | Modi P Edwards A Fox B | 2005 | Eur J Cardiothorac Surg2005，27，1： | 1 |
| 16 | Compariation of AFLP and Pedigree-based genetic diversity assessment methods us- ing wheat euhivars from the Pacific Northwest 显示文摘 | Barrett B A Kidwell K K Fox P N | 1998 | Crop Sci1998，38，： | 1 |
| 17 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 18 | Microbiology and biochemistry of fossa (pit) cheese 显示文摘 | GOBBETTI M FOLKERTSMA B FOX P F | 1999 | Int Dairy J1999，9，： | 1 |
| 19 | Absenceof effects of short-term fasting on plasma ghrelin andbrain expression of ghrelin receptors in the tilapia,Oreochromis mossambicus 显示文摘 | RILEY L G FOX B K BREVES J P | 2008 | Zoological Science2008，25，8： | 1 |
| 20 | The Pim kina-ses control rapamycin - resistant T cell survival and activation 显示文摘 | FOX C J HAMMERMAN P S THOMPSON C B | 2005 | J Exp Med2005，201，2： | 1 |
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