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| 1 | 皮肤表面pH值及其临床意义显示文摘皮肤表面pH值是皮肤的生理指标之一,它随机体的不同生长发育时期和皮肤的生物状态的不同而不同。老年人及新生儿皮肤表面pH值较高;某些皮肤病可导致皮肤表面pH值升高。皮肤表面pH值升高可直接或间接影响角质形成细胞的代谢,从而引起角质形成细胞增生、分化的异常,皮肤屏障功能改变,角质层致密性降低等。因此,测量皮肤表面pH值对判断表皮乃至整个机体的生物状态具有重要参考价值;皮肤表面pH值维持在最佳生理水平对延缓皮肤老化、防止和治疗某些皮肤病具有一定的指导意义。 | 蔄茂强 辛淑君 Peter M Elias | 2007 | 中国皮肤性病学杂志2007，21，8： | 47 |
| 2 | 我国正常人皮肤表面皮脂和水分含量的研究显示文摘目的:了解我国不同年龄、不同性别正常人皮肤角质层含水量、皮肤表面皮脂含量及皮肤皮脂的分泌速度。方法:利用皮肤表面皮脂测量仪和皮肤水分含量测量仪对我国北方325名正常人的前额及前臂屈侧皮肤皮脂量和皮肤含水量进行测量。结果:12岁以前,男女前额皮脂量无差异;13岁以后,男性前额的皮脂量明显高于女性。除36~50岁年龄组外,女性前额的皮脂分泌快于男性。男女前臂的皮脂量无差异。除男性13~35岁组的前额皮肤含水量高于女性外,其他各年龄组各部位男、女皮肤含水量无显著差别。13~35岁组男、女性前额的含水量均高于前臂。其他各年龄组前额和前臂皮肤含水量无明显部位差异。13~35岁组男性前额皮肤含水量最高。结论:正常人皮肤表面含水量和皮脂含量因性别、年龄和部位的不同而有差异。 | 辛淑君 刘之力 史月君 Kenneth R Feingold Peter M Elias 蔄茂强 | 2007 | 临床皮肤科杂志2007，36，3： | 26 |
| 3 | 正常人皮肤表面酸碱度的研究显示文摘皮肤是人类机体的重要组成部分.皮肤表面的酸碱度不仅是皮肤的生理指标.同时也反映了整个机体的状态。迄今为止,关于正常人皮肤表面pH值的报道不尽相同。据报道,婴儿出生时,皮肤表而的pH较高。数天后则逐渐降低。Wilhelm等曾对29例成人皮肤表面的pH进行了研究,结果发现,皮肤表而的pH囚皮肤解剖部位的不同而不同:老年人的前额和踝部皮肤表而的pH值高于年轻者。Zlotogorski的研究也证实了Wilhelm等的结果.但是也有报道,皮肤表面的pH因性别的差异而不同。这种差异性有多种因素,可能与研究组别的大小和分组的条件等有关。关于我国正常人皮肤表面pH的研究报道较少,笔者根据人体生长发育期的生理特点进行年龄分组;根据皮肤的生理特点进行部位分组。对我国正常人不同年龄、不同性别和不同部位的皮肤pH进行检测,为临床工作提供参考。 | 辛淑君 刘之力 史月君 Kenneth R Feingold Peter M Elias 蔄茂强 | 2007 | 临床皮肤科杂志2007，36，5： | 11 |
| 4 | 特应性皮炎患者皮肤的水通透屏障功能改变及其临床意义显示文摘皮肤的生理指标包括皮肤的水通透屏障功能、角质层的水分含量以及皮肤表面的pH值等,这些生理指标反映了机体和皮肤局部的生理状态。除角质层的水分含量降低以及皮肤表面的pH值升高外,特应性皮炎(AD)患者皮肤屏障功能明显降低。这一变化是AD表皮病变所致,其可影响表皮和真皮的功能。皮肤生理的改变程度与病情有关,通过改善皮肤屏障功能可以缓解AD病情。因此,正确地了解AD患者皮肤屏障功能的改变对于病情的判断和疾病的防治有一定的临床指导意义。 | 蔄茂强 Peter M Elias | 2007 | 临床皮肤科杂志2007，36，10： | 11 |
| 5 | ESPEN Guidelines for Nutrition Screening 2002显示文摘 | J Kondrup S.P Allison M Elia B Vellas M Plauth | 2003 | Clinical Nutrition2003，，4： | 11 |
| 6 | 敏感性皮肤及其处理对策显示文摘敏感性皮肤是指皮肤对多种内外因素的耐受性降低、敏感性增强。敏感皮肤的发生与年龄、性别、身体解剖部位以及种族有关。敏感性皮肤者生活质量下降。由于其病因不明,有效控制敏感性皮肤一直是个挑战。近来研究显示,表皮通透屏障功能和瞬时感受器电位香草酸受体与敏感性皮肤的发生有关。因此,改善表皮通透屏障功能和瞬时感受器电位香草酸受体抑制剂可能有助于改善敏感性皮肤。 | 蕳茂强 Se Kyoo Jeong Byeong Deog Park Peter M Elias | 2016 | 中华皮肤科杂志2016，49，12： | 8 |
| 7 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 8 | 表皮通透屏障功能与表皮CD44表达关系的研究显示文摘目的:研究表皮通透屏障功能破坏后表皮CD44的表达。方法:外用胶带破坏裸鼠躯干部表皮通透屏障功能,分别于30min、1h、3h、6h、24h和48h后取皮肤标本,用免疫组化的方法观察CD44在表皮的表达。结果:在表皮通透屏障功能破坏后30min,表皮CD44的表达明显上调;1h和3h后,恢复至正常水平;6h后,表皮CD44的表达又明显增强,并持续到48h;人为地纠正屏障功能(封包)对表皮CD44的表达没有明显影响。结论:表皮通透屏障功能破坏后,表皮CD44的表达增强,其表达的改变与屏障功能本身无显著相关性。 | Mona Man 吕成志 辛淑君 Kenneth R Feingold Peter M Elias 蔄茂强 | 2008 | 临床皮肤科杂志2008，37，7： | 5 |
| 9 | 紫外线照射对表皮通透屏障功能的影响及其意义显示文摘紫外线照射是影响皮肤生物功能最常见的因素之一.大部分皮肤鳞状细胞癌和基底细胞癌发生在曝光部位;皮肤弹性降低、皱纹增多也是常见的紫外线导致的损伤.皮肤色素增多、炎症形成及晒伤等也是与紫外线照射有关的皮肤病.此外,紫外线照射对表皮通透屏障功能也有不同程度的影响.然而,在防治紫外线照射对皮肤的损伤过程中,改善表皮通透屏障功能常常被忽略.为此,本文仅就紫外线照射对表皮通透屏障功能的影响及意义做一简述. | 蔄茂强 Peter M Elias | 2010 | 中华皮肤科杂志2010，43，12： | 5 |
| 10 | Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?显示文摘Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue(NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is essential to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. Since antiviral immunity plays an essential role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe NA discontinuation in both groups. | Elia Moreno-Cubero Robert T Sánchez del Arco Julia Pena-Asensio Eduardo Sanz de Villalobos Joaquín Míquel Juan Ramón Larrubia | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 11 | 糖皮质激素对表皮功能的调节显示文摘糖皮质激素是临床上最常用的药物之一。它对表皮的发育、表皮屏障功能的形成、表皮脂代谢、角质层致密性、角质形成细胞的增生和分化均具有重要的调节作用。恰当地应用糖皮质激素能有利于治疗包括皮肤病在内某些疾病;使用不当可引起严重的不良反应。因此,很好地了解糖皮质激素对表皮功能的影响,对于指导临床合理应用糖皮质激素以及防治由其引起的不良反应具有重要意义。 | 蔄茂强 宋顺鹏 Kenneth R.Feingold Peter M Elias | 2009 | 临床皮肤科杂志2009，38，12： | 4 |
| 12 | 中国正常老年人与年轻人皮肤共振传导特性比较显示文摘目的研究中国正常老年人和年轻人不同部位皮肤共振传导特性。方法152例年龄20~40岁的正常年轻人和64例年龄60~88岁的正常老年人参加本研究。利用Reviscometer RVM600分别于左手背、左前臂屈侧、前额及左眼外眦处测量不同方向皮肤共振传导时间(CRRT)。结果CRRT因测量部位和方向的不同而不同。在前臂,除在2—8点方向外,其他各方向老年人的CRRT大于年轻人:0—6点方向,f=7.46;1—7点方向,f=3.38;3—9点方向,t=3.88;4—10点方向,f=6.82;5—11点方向,卜7.42,P值〈0.01或〈0.05。在手背部位,除在3—9点方向外,其他各方向年轻人的CRRT则大于老年人:0—6点方向,t=4.53;1—7点方向,t=5.71;2—8点方向,t=2.74;4—10点方向,t=2.67;5—11点方向,t=4.20,P值均〈0.01或〈0.05。在前额部位,年轻人的CRRT与老年人差异无统计学意义。在眼外眦部位的1—7点和2—8点方向,年轻人CRRT大于老年人:1—7点方向,t=3.18,P〈0.01;2—8点方向,k5.11,P〈0.01。男女之间各部位CRRT没有明显差异。结论CRRT因年龄、方向及部位的不同而不同,性别对CRRT没有明显影响。 | 辛淑君 朱英华 吕成志 Kenneth R. Feingold Peter M Elias 蔄茂强 | 2010 | 中华皮肤科杂志2010，43，4： | 4 |
| 13 | 钙离子对表皮屏障功能的调节显示文摘在正常的表皮内存在着钙离子浓度梯度,自基底细胞层到颗粒层,细胞内、外钙离子浓度由低到高;而角质层中钙离子浓度较低。这种钙离子浓度梯度对于表皮的增生、分化、细胞间连接及屏障功能起着重要的作用。细胞外低浓度钙促进角质形成细胞增生;高浓度钙促进角质形成细胞分化、细胞间黏附。完整的表皮屏障功能是保证表皮钙离子浓度梯度的前提,当屏障功能被破坏后,颗粒层细胞内、外的钙离子浓度降低有促进屏障功能恢复的作用。随着屏障功能恢复,表皮钙离子浓度梯度也恢复正常。许多与屏障功能相关的炎症性皮肤病和与表皮松解相关的皮肤病往往伴有表皮钙离子浓度梯度的异常。 | 吴艳 陈璨 Peter M Elias 蕳茂强 | 2010 | 临床皮肤科杂志2010，39，2： | 4 |
| 14 | 表皮生理功能改变在特应性皮炎皮肤瘙痒发生中的作用显示文摘瘙痒是指皮肤对于刺激所导致搔抓反应的欲望.很多系统和皮肤疾病均可导致皮肤瘙瘴,根据起源的不同可将瘙痒分为不同的类型。皮肤型瘙痒是由于皮肤病变而导致的瘙痒,是临床最常见的瘙痒类型’。皮肤型瘙痒患者往往伴有表皮生理功能(包括表皮通透屏障功能、角质层含水量和表皮酸碱度)异常,如银屑病、湿疹和特应性皮炎。改善表皮功能可能是治疗特应性皮炎患者皮肤瘙痒及相关疾病(包括患者生活和睡眠质量)的有效方法。 | 茼茂强 马琳 Peter M Elias 胡立志 | 2017 | 中华皮肤科杂志2017，50，12： | 4 |
| 15 | TLR2和TLR4在不同皮炎模型皮肤的表达显示文摘目的研究Toll样受体2(TLR2)和TLR4在不同皮肤炎症的表达是否有区别。方法分别外涂弗博酯、oxazolone或胶带法于裸鼠躯干部制作皮炎模型。用免疫组化的方法观察TLR2和TLR4在真皮和表皮的表达。结果皮炎上调TLR2在表皮的表达及TLR4在真皮的表达;分别外涂弗博酯及oxazolone所诱发的皮炎中炎症细胞浸润较为明显,其TLR2和TLR4的表达增强也较明显;胶带法所诱导的皮炎中其炎症细胞浸润较轻,TLR2和TLR4的表达也较轻。结论皮炎分别上调皮肤TLR2和TLR4在真皮和表皮的表达;TLR2表达增强的程度与炎症程度有关。 | 吕成志 Mona Man 张信江 Kenneth R Feingold Peter M Elias 蔺茂强 | 2009 | 中国皮肤性病学杂志2009，23，7： | 4 |
| 16 | 改善表皮通透屏障功能对特应性皮炎的防治作用显示文摘表皮通透屏障是皮肤的防御功能之一,它不仅影响物质透过皮肤进出机体以及微生物的侵入,对皮肤的其他生物功能也具有重要的调节作用。表皮通透屏障功能降低是一些皮肤病(包括特应性皮炎和银屑病)发病的主要因素之一。改善表皮通透屏障功能有助于防治这些皮肤病,已成为防治特应性皮炎的手段之一。 | 蔄茂强 Se Kyoo Jeong Byeong Deog Park Peter M Elias | 2015 | 中华皮肤科杂志2015，48，11： | 3 |
| 17 | ESPEN Guidelines for Nutrition Screening 2002显示文摘 | J Kondrup S.P Allison M Elia B Vellas M Plauth | 2003 | Clinical Nutrition2003，，4： | 2 |
| 18 | 雌激素对表皮功能的调节作用显示文摘除真皮、皮脂腺及毛囊外,表皮也是雌激素作用的主要器官之一。雌激素受体广泛地分布于角质形成细胞中;临床上,雌激素水平的降低可导致皮肤干燥和萎缩;妊娠期银屑病减轻,而产后则加重。雌激素对外伤的愈合及色素的生成有促进作用。此外,雌激素与皮肤黑素瘤及角质形成细胞的增生也有明显的关系。因此,进一步了解雌激素对皮肤功能的调节作用有助于对某些皮肤病的诊断、预防和治疗。 | 蔄茂强 宋顺鹏 Peter M Elias | 2009 | 中国皮肤性病学杂志2009，23，9： | 2 |
| 19 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 20 | 局部外用砷制剂对鼠角质层致密性的影响显示文摘目的:研究砷是否引起皮肤角质层功能的改变,为探索砷治疗皮肤病提供实验依据。方法:6~8周龄的裸鼠背部和躯干两侧分别外涂基质、0.5mmol/L和1.5mmol/L三化二砷。每日2次,每次60μL,共2周。用Courage-Khazaka多功能皮肤生理仪测量皮肤表面的基础黑素(melanin)含量、角质层含水量、皮肤表面皮脂含量、皮肤通透屏障功能及角质层的酸碱度。此外,对皮肤屏障功能的恢复速度、角质层的致密性也进行测量。结果:在此动物模型中,0.5mmol/L和1.5mmol/L的二三氧化二砷均导致角质层pH值升高和角质层的致密性降低:1.5mmol/L的三氧化二砷增加皮肤的黑素含量。与对照组相比,0.5mmol/L和1.5 mmol/L的三氧化二砷对角质层含水量、基础皮肤通透屏障功能以及屏障功能的恢复速度均无明显的影响。虽然两种浓度的砷均引起皮肤表面皮脂含量的轻微增加,但与对照组相比,差异无统计学意义。结论:砷可以引起角质层生理功能的改变,可以导致皮肤对砷通透性增加。在预防或治疗皮肤砷中毒时,增强角质层的防御功能是不可忽视的环节。 | 吕成志 辛淑君 张信江 史月君 Kenneth R Feingold Peter M Elias 蔄茂强 | 2007 | 临床皮肤科杂志2007，36，12： | 2 |
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