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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 3 | A novel orthotopic and metastatic mouse model of breast cancer in human mammary microenvironment(摘要)显示文摘 | Wang, J Xia, TS Liu, XA Ding, Q Du, Q Yin, H Wang, S | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 4 |
| 4 | On the zeros and asymptotic behavior of minimizers to the Ginzburg-Landau functional with variable coefficient显示文摘 | Ding S J Liu Z H | 1997 | J Partial Diff Eqs1997，10，： | 2 |
| 5 | Theoretical study of BexZn1-xO alloys显示文摘 | Ding S F Fan G H Li S T | 2007 | Physiea B2007，394，： | 1 |
| 6 | Time domain buffeting analysis of suspension bridge subjected to turbulent wind with effective action angle显示文摘 | Ding Q Lee P K K Lo S H | 2000 | Journal of Sound and Vibration2000，233，2： | 1 |
| 7 | A viral protein inhibits the long range signaling activity of the gene silencing signal 显示文摘 | Guo H S Ding S W | 2002 | The EMBO Journal2002，21，： | 1 |
| 8 | Aeolian origin of the redearth in southeast China显示文摘 | Xiong S F Sun D H Ding Z L | 2002 | Journal of Quaternary Science2002，17，： | 1 |
| 9 | Analysis of nonylphenol polyethoxylates and their degradation products in river water and sewage effluent by gas chromatography- ion trap (tandem) mass spectrometry with electron impact and chemical ionization 显示文摘 | DING W H TZING S H | 1998 | Journal of Chromatography A1998，824，1： | 1 |
| 10 | A viral protein inhibits the long range signaling activity of the gene silencing signal显示文摘 | Guo H S Ding S W | 2002 | The EMBO J2002，21，3： | 1 |
| 11 | 显示文摘 | Ding S J Ju C P Lin J H C | 2000 | Journal of Materials Science:Materials in Medicine2000，11，1： | 1 |
| 12 | XPS studies on the electronic structure of bonding between solid and solutes:Adsorption of arsenate,chromate,phosphate,Pb2+,and Zn2+ ions on amorphous black ferric oxyhydroxide显示文摘 | DING M JONG B H W S DE ROOSENDAAL S J | 2000 | Geochimica et Cosmochimica Acta2000，64，6： | 1 |
| 13 | 显示文摘 | Kong H Z Wee A T S Ding J | 2004 | International Journal of Nanoscience2004，3，45： | 1 |
| 14 | Simulation of stationary Gaussian stochastic wind velocity field显示文摘 | Ding Q S Zhu L D Xiang H F | 2006 | Wind and Structures2006，9，3： | 1 |
| 15 | Temperature-Dependent Photoluminescence of ZnO Nanorods Prepared by a Simple Solution Route显示文摘 | Lv Y Z Zhang Y H Li C P Ren L R Guo L Xu H B Ding L Yang C L Ge W K and Yang S H | 2007 | Luminescence2007，，： | 1 |
| 16 | Combined fascial flap and expanded skin flap for enveloping Medpor framework in microtia reconstruction显示文摘 | YANG S L ZHENG J H DING Z | 2009 | Aesthetic Plast Surg2009，33，4： | 1 |
| 17 | Hydrotreating of light cycle oil using WNi catalysts containing hydrothermally and chemically treated zeolite Y 显示文摘 | DING L H ZHENG Y ZHANG Z S | 2007 | Catal Today2007，125，3： | 1 |
| 18 | The Differential Expres- sion of Hepatic Genes Between Prelaying and Laying Geese显示文摘 | S T Ding C F Yen P H Wang | 2007 | Poultry Science2007，86，： | 1 |
| 19 | Numerical Simulation and Analysis of Tapered Interference Fit of Atomizer Disk 显示文摘 | Lin S H Li C J Ding J P | 2012 | AppIied Mechanics and Materials2012，201，： | 1 |
| 20 | On chip droplet characterization: a practical, high sensitivity measurement of droplet impedance in digital microfluidics显示文摘 | SADEGHI S DING H SHAH G J | 2012 | Analytical chemistry2012，84，4： | 1 |
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