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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Biliary-colonic fistula caused by cholecystectomy bile duct injury显示文摘Biliary-colonic fistula is a rare complication after laparoscopic cholecystectomy. We present a case of post-cholecystectomy iatrogenic biliary injury that resulted in a fistula between the common hepatic duct and large bowel. Magnetic resonance cholangiopancreatography provided good visualization of injury even with concurrent normal level of alkaline phosphatase. Radiologic findings and surgical management of this condition are discussed in detail. | Francisco Igor B Macedo Victor J Casillas James S Davis Joe U Levi Danny Sleeman | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 2 |
| 3 | X-ray interactions: photabsorption, scattering, transmission, and reflection at E-50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Tables1993，54，： | 2 |
| 4 | An interactive process planning system for prismatic parts显示文摘 | ESKICIOGLU H DAVIES B J | 1983 | Annals of CIRP1983，32，1： | 1 |
| 5 | Commutation failures in HVDC transmission systems显示文摘 | Thio C V Davies J B Kent K L | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
| 6 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 7 | X-ray interactions: photoabsorption scattering, transmission and reflection at E=50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，： | 1 |
| 8 | The Nature and Biosynthesis of the Carotenoids of Different Color Varieties of Capsicum annuum显示文摘 | B H Davies S Matthew J T O Kirk | 1970 | Phytochemistry1970，，9： | 1 |
| 9 | Di-( 2-ethylhexyl ) phthalate suppresses estradiol and ovulation in cycling rats 显示文摘 | Davis B J Maronpot R R Heindel J J | 1994 | Tox- icol Appl Pharmacol1994，128，2： | 1 |
| 10 | Three-dimensionalseismic imaging of dikefed submarine volcanoes显示文摘 | Davies R Bell B Cartwright J A | 2002 | Geology2002，30，： | 1 |
| 11 | Endotoxin removal devices for thetreatment of sepsis and septic shock 显示文摘 | DAVIES B COHEN J | 2011 | Lancet Infect Dis2011，11，1： | 1 |
| 12 | Long-term carbon dioxide fluxes from a very tall tower in a northern forest:flux measurement method,ology显示文摘 | BERGER B W DAVIS K J YI C | 2001 | Atmos Ocean Technol2001，18，： | 1 |
| 13 | The autonomous underwater glider 'Spray' 显示文摘 | Sherman J Davis R E Owens W B | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 14 | High-flow nasal cannulae for respiratory support of preterm infants: a review of the evi- dence 显示文摘 | Manley B J Dold SK Davis PG | 2012 | Neonatology2012，102，4： | 1 |
| 15 | Mechanisms of phthalate ester toxicity in the female reproductive system显示文摘 | LOVEKAMP S T DAVIS B J | 2003 | Environ Health Perspect2003，111，2： | 1 |
| 16 | Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein显示文摘 | Davis B Koster G Douet L J | | 0，，10： | 1 |
| 17 | Commutation Failures in HVDC Transmission Systems显示文摘 | THIO C V DAVIES J B KENT K L | | 0，，02： | 1 |
| 18 | Chromium oligopeptide activates insulin receptor tyrosin kinase activity 显示文摘 | Davis C M Vincent J B | 1997 | Biochem1997，36，15： | 1 |
| 19 | The expression of calbindin in chicks that are divergently selected for low or high incidence of tibial dyschondroplasia显示文摘 | SHIRLEY R B DAVIS A J COMPTON M M | 2003 | Poultry Science2003，82，12： | 1 |
| 20 | Integration of inspection planning system and CMM via DMIS 显示文摘 | TANG X Q DAVIES B J | 1995 | International Journal of Advanced Manufacturing Technology1995，10，6： | 1 |
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