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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Biliary-colonic fistula caused by cholecystectomy bile duct injury显示文摘Biliary-colonic fistula is a rare complication after laparoscopic cholecystectomy. We present a case of post-cholecystectomy iatrogenic biliary injury that resulted in a fistula between the common hepatic duct and large bowel. Magnetic resonance cholangiopancreatography provided good visualization of injury even with concurrent normal level of alkaline phosphatase. Radiologic findings and surgical management of this condition are discussed in detail. | Francisco Igor B Macedo Victor J Casillas James S Davis Joe U Levi Danny Sleeman | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 2 |
| 3 | Rainbow trout has two genes for growth hormone显示文摘 | Agellon L B Davies S L Lin C M | 1988 | Mol Rep Develop1988，1，： | 1 |
| 4 | Seasonal variations of trace metal chemical forms in bed sediments of a karstic river in Lebanon: implications for self-purification 显示文摘 | Korfali S I Davies B E | 2005 | Environmental Geochemistry and Health2005，27，： | 1 |
| 5 | Stomatal control by chemical signaling and the exploitation of this mechanism to increase water use effeciency in agricuture显示文摘 | DAVIES WJ WILKINSON S LOVEYS B | 2002 | The New Phytologist2002，153，： | 1 |
| 6 | Use of hypertonic saline in the treatment of severe refractory posttraumatic intracranial hypertesion in pediatric traumatic brain injury显示文摘 | Khanna S Davis D Peterson B | 2000 | Crit Care Med2000，28，4： | 1 |
| 7 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 8 | The Nature and Biosynthesis of the Carotenoids of Different Color Varieties of Capsicum annuum显示文摘 | B H Davies S Matthew J T O Kirk | 1970 | Phytochemistry1970，，9： | 1 |
| 9 | Mechanisms of phthalate ester toxicity in the female reproductive system显示文摘 | LOVEKAMP S T DAVIS B J | 2003 | Environ Health Perspect2003，111，2： | 1 |
| 10 | Regulation of mammalian autophagy in physiology and pathophysiology显示文摘 | Ravikumar B Sarkar S Davies JE | 2010 | Physiol Rev2010，90，4： | 1 |
| 11 | Structure of a fish (rainbow trout) growth hormone gene and its evolutionary implications显示文摘 | Davies S L Chen T T | 1988 | Proc Natl Acad Sci USA1988，85，： | 1 |
| 12 | Comparison of parametricrepresentations of monosyllabic word recognition in continuously spoken sentences显示文摘 | MERMELSTEIN P | 1980 | IEEE Trans on Speech and Audio Processing1980，28，4： | 1 |
| 13 | The temperature of Europe during the Holoeene reconstructed from pollen data显示文摘 | Davis B A S Brewer S Stevenson A C | 2003 | Quaternary Science Reviews2003，22，1517： | 1 |
| 14 | Development of a healthy biscuit: an alternative approach to biscuit manufacture 显示文摘 | W J Boobier J S Baker B Davies | 2006 | Nutri J2006，5，： | 1 |
| 15 | Regulation of mammalian autophagy in physiology and pathophysiology显示文摘 | Ravikumar B Sarkar S Davies JE | 2010 | Physiol Rev2010，90，： | 1 |
| 16 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 17 | Ex-pression patterns of cell wall-modifying enzymes during grape ber-ry development显示文摘 | NUNAN K J DAVIES C ROBINSON S P FINCHER G B | 2001 | Planta2001，214，2： | 1 |
| 18 | Mode of International Entry:An Isomorphism Perspective显示文摘 | Davis P S Desai A B Francis J D | 2000 | Journal of International Business Studies2000，31，2： | 1 |
| 19 | The policy continuum-Policy authoring and conflict analysis显示文摘 | Davy S Jennings B Strassner J | 2008 | Computer Communications2008，31，： | 1 |
| 20 | Bioelectrochemical single-walled, carbon nanotubes显示文摘 | AZAMIAN B R DAVIS J J COLEMAN K S | 2002 | Journal of the American Chemical Society2002，124，12： | 1 |
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