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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Plant thermal hysteresis proteins显示文摘 | URRUTIA M E DUMAN J G KNIGHT C A | 1992 | Biochim Biophys Acta1992，1121，1： | 1 |
| 3 | Elevated serum CA12 levels in mitral stenotic patientswith heart failure 显示文摘 | Duman C Ercan E Tengiz I | 2003 | Cardiology2003，100，： | 1 |
| 4 | Effects of pentoxifylline on TNF-alph'a production by peripheral blood mononuclear cells in patients with nonalcoholic steatohepatitis显示文摘 | Duman DG Ozdemir F Birben E | 2006 | Gastroenterology2006，130，4： | 1 |
| 5 | Elevated serum CA125 levels in mitral stenotic patients with heart failure 显示文摘 | Duman C Ercan E Tengiz I | 2003 | Cardiology2003，100，1： | 1 |
| 6 | Elevated serum CA 125 levels in mitraI stenotic patients with heart failure显示文摘 | Duman C Ercan E Tengiz I | | 0，，09： | 1 |
| 7 | The Quadratic Assignment Problem in the Context of the Printed Circuit Board Assembly Process显示文摘 | DUMAN E OR I | | 0，，： | 1 |
| 8 | The role of the vacuum-assistedclosure therapy in the salvage of venous congestion of the free flap:case report显示文摘 | Uygur F Duman H UlkQ r E | 2008 | Int Wound J2008，5，1： | 1 |
| 9 | Inverse magnetocaloric effect in ferromagnetic Ni-Mn-Sn alloys显示文摘 | Krenke T Duman E Acet M | 2005 | Nat Mater2005，4，6： | 1 |
| 10 | A new approach for immobilization of oligonucleotides onto piezoelectric quartz crystal for preparation of a nucleic acid sensor for following hybridization显示文摘 | Duman M Saber R Piskin E | 2003 | Biosens Bioelectron2003，18，11： | 1 |
| 11 | Plant thermal hysteresis proteins显示文摘 | Urrutia M E Duman J G Knight C A | 1992 | Biochim Biophy Acta1992，1121，1： | 1 |
| 12 | Jaw bone changes in rats after treatment with zoledronate and pamidronate 显示文摘 | Senel FC Duman MK Muci E | 2010 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2010，109，3： | 1 |
| 13 | Serum carbohydrate antigen 125 lev- els in advanced heart failure:relation to B-type natriuretic peptide and left atrial volume 显示文摘 | Duman D Palit F Simsek E | 2008 | European Journal of Heart Failure2008，10，6： | 1 |
| 14 | Midterm results of Oxford phase 3 unicondylar knee arthroplasty for medial osteoarthritis显示文摘 | Asian H Ersan O Baz AB Duman E Aydin E AtesY | 2007 | Acta Orthop Traumatol Turc2007，41，： | 1 |
| 15 | The value of aortic pulse wave velocity in predicting coronary artery disease diagnosis and severity显示文摘 | Duman OO Goldeli O Gursul E | 2015 | Acta Cardiol2015，70，3： | 1 |
| 16 | Serum carbohydrate antigen 125 levels in advanced heart failure: Relation to B - type natri- uretic peptide and left atrial volume显示文摘 | Duman D Palit F Simsek E | 2008 | Eur J Heart Fail2008，10，6： | 1 |
| 17 | Serum carbohydrate antigen125levels in advanced heart failure:Relation to B-type natriuretic and left atrial volume显示文摘 | Duman D Palit F Simsek E | 2008 | Eur J Heart Fail2008，10，： | 1 |
| 18 | The many faces of CREB 显示文摘 | CARLEZON JR W A DUMAN R S NESTLER E J | 2005 | Trends in Neurosciences2005，28，： | 1 |
| 19 | Reconstruction of distal forefoot burn defect with retrograde medial plantar flap显示文摘 | Uygur F Duman H Ulkor E | 2008 | Burns2008，34，26： | 1 |
| 20 | Elevated serum CA 125 levels in mitral patients with heart failure显示文摘 | DUMAN C ERCAN E TENGIZ I | 2003 | Cardiology2003，10，： | 1 |
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