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| 1 | Clinical outcome and predictors of survival after TIPS insertion in patients with liver cirrhosis显示文摘AIM:To determine the clinical outcome and predictors of survival after transjugular intrahepatic portosystemic stent shunt (TIPS) implantation in cirrhotic patients. METHODS:Eighty-one patients with liver cirrhosis and consequential portal hypertension had TIPS implantation (bare metal) for either refractory ascites (RA) (n= 27) or variceal bleeding (VB) (n = 54). Endpoints for the study were:technical success, stent occlusion and stent stenosis, rebleeding, RA and mortality. Clinical records of patients were collected and analysed. Baseline characteristics [e.g., age, sex, CHILD score and the model for end-stage liver disease score (MELD score), underlying disease] were retrieved. The Kaplan-Meier method was employed to calculate survival from the time of TIPS implantation and comparisons were made by log rank test. A multivariate analysis of factors influencing survival was carried out using the Cox proportional hazards regression model. Results were expressed as medians and ranges. Comparisons between groups were performed by using the Mann-Whitney Utest and the χ 2 test as appropriate. RESULTS:No difference could be seen in terms of age, sex, underlying disease or degree of portal pressure gradient (PPG) reduction between the ascites and the bleeding group. The PPG significantly decreased from 23.4 ± 5.3 mmHg (VB) vs 22.1 ± 5.5 mmHg (RA) before TIPS to 11.8 ± 4.0 vs 11.7 ± 4.2 after TIPS implantation (P = 0.001 within each group). There was a tendency towards more patients with stage CHILD A in the bleeding group compared to the ascites group (24 vs 6, P = 0.052). The median survival for the ascites group was 29 mo compared to > 60 mo for the bleeding group (P = 0.009). The number of radiological controls for stent patency was 6.3 for bleeders and 3.8 for ascites patients (P = 0.029). Kaplan-Meier calculation indicated that stent occlusion at first control (P = 0.027), ascites prior to TIPS implantation (P = 0.009), CHILD stage (P = 0.013), MELD score (P = 0.001) and those patients not having undergone liver transplantation (P = 0.024) were significant predictors of survival. In the Cox regression model, stent occlusion (P = 0.022), RA (P = 0.043), CHILD stage (P = 0.015) and MELD score (P = 0.004) turned out to be independent prognostic factors of survival. The anticoagulation management (P = 0.097), the porto-systemic pressure gradient (P= 0.460) and rebleeding episodes (P = 0.765) had no significant effect on the overall survival. CONCLUSION:RA, stent occlusion, initial CHILD stage and MELD score are independent predictors of survival in patients with TIPS, speaking for a close follow-up in these circumstances. | Hauke S Heinzow Philipp Lenz Michael Khler Frank Reinecke Hansjrg Ullerich Wolfram Domschke Dirk Domagk Tobias Meister | 2012 | World Journal of Gastroenterology2012，18，37： | 17 |
| 2 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 3 | High Prevalence of Viral Genomes and Multiple Viral Infections in the Myocardium of Adults With “Idiopathic” Left Ventricular Dysfunction显示文摘 | Uwe Kühl Matthias Pauschinger Michel Noutsias Bettina Seeberg Thomas Bock Dirk Lassner Wolfgang Poller Reinhard Kandolf Heinz-Peter Schultheiss | 2005 | Circulation2005，，7： | 2 |
| 4 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 5 | Trust in Leadership and Team Performance:Evidence from NCAA Basketball显示文摘 | DIRKS K T | 2000 | Journal of Applied Psychology2000，85，6： | 1 |
| 6 | The role of trust in organiza- tional settings 显示文摘 | Dirks K T Ferrin D L | 2001 | Organization Science2001，12，4： | 1 |
| 7 | High-resolution studies of rainfall on Norfolk Island Part II:interpolation of rainfall data 显示文摘 | Dirks K N Hay J E Stow C D | 1998 | Journal of Hydrology1998，208，3： | 1 |
| 8 | A holistic aging model for Li(NiMnCo)O 2 based 18650 lithium-ion batteries显示文摘 | Johannes Schmalstieg Stefan K?bitz Madeleine Ecker Dirk Uwe Sauer | 2014 | Journal of Power Sources2014，，： | 1 |
| 9 | The role of trust in organization set-tings显示文摘 | Dirks K T Ferrin D L | 2001 | Organization Science2001，12，： | 1 |
| 10 | Randomised comparison of epinephrine and vasopressin in patients with out-of-hospital ventvicular fibrillation显示文摘 | LINDNER K H DIRKS B STROHMENGER H U | 1997 | Lancet1997，349，： | 1 |
| 11 | Toward a theory of psychological ownership in organizations显示文摘 | Pierce J L Kostova T Dirks K T | 2001 | Academy of Management Review2001，26，2： | 1 |
| 12 | The repair of trust: A dynamic bilateral perspective and multilevel conceptualization显示文摘 | Kim P H Dirks K T and Cooper C D | 2009 | Academy of Management Review2009，34，3： | 1 |
| 13 | The Use of Rewards to Increase and Decrease Trust:Mediating Processes and Differential Effects显示文摘 | Ferrin D L Dirks K T | 2003 | Organization Science2003，，： | 1 |
| 14 | Trust in leadership and team performanee:Evidence from NCAA baskethall显示文摘 | Dirks K T | 2000 | Journal of Applied Psychology2000，85，： | 1 |
| 15 | The natural history of meconium peritonitis diagnosed in utero显示文摘 | Dirkes K Crombleholme TM Craigo SD | 1995 | J Pediatr Surg1995，30，： | 1 |
| 16 | The repair of trust : A dy-namic bilateral perspective and multilevel conceptualization显示文摘 | Kim P H Dirks K T Cooper C D | 2009 | Academy of Management Review2009，34，3： | 1 |
| 17 | The Role of Trust in Organizational Settings显示文摘 | Dirks K T Ferrin D L | 2001 | Organization Science2001，12，45： | 1 |
| 18 | Trust in Leadership:Meta-analytic Findings and Implications for Research and Practice显示文摘 | Ferrin D L | 2002 | Journal of Applied Psychology2002，，4： | 1 |
| 19 | Multiresolution reproducing kernel particle method for computational fluid dynamics 显示文摘 | Liu W K Sukky J Dirk T S | | International Journal for numericalmethods in fluids0，，： | 1 |
| 20 | Expression of p57(KIP2)potently blocks the growht oh human astrocytomas and induce cell senscence显示文摘 | TSUGU A SAKAI K DIRKS P B | 2000 | Am J Pathol2000，157，3： | 1 |
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