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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 3 | 公路隧道火灾的数值模型显示文摘 | Cox,G 何声虎 | 1989 | 隧道译丛1989，，8： | 5 |
| 4 | 用可调式涡轮增压技术降低排放并改善扭矩特性显示文摘目前,欧洲80%的轿车柴油机已采用涡轮增压。随着排放标准的日益严格,在不久的将来,涡轮增压机型有望接近100%。目前的一个主要热点是在高速柴油机上采用可调式涡轮增压技术(VGT)。在一台1.8L直喷式柴油机上做了大量的稳态试验研究,旨在对可调式涡轮增压发动机与配置带放气阀增压器的基准发动机进行比较,以观其潜在的益处。在欧洲试验循环中对排放产物十分重视的部分负荷工况下,分别控制可调增压器的叶片位置和废气再循环(EGR)阀的位置,以优化排放指标。在不牺牲固定式增压发动机的燃油耗、烟度的前提下,在一些间断工况点测得的NO_X减少到45%。在满足最高爆发压力、烟度和涡轮前温度限制条件下,可调增压发动机与装有固定增压基准发动机相比最大扭矩提高了10%。 | Hawley J G Wallace F J Cox A 栾敏 董复兴 | 2000 | 国外内燃机2000，，3： | 3 |
| 5 | Donor-specific cell-free DNA as a biomarker in liver transplantation:A review显示文摘Due to advances in modern medicine,liver transplantation has revolutionised the prognosis of many previously incurable liver diseases.This progress has largely been due to advances in immunosuppressant therapy.However,despite the judicious use of immunosuppression,many liver transplant recipients still experience complications such as rejection,which necessitates diagnosis via invasive liver biopsy.There is a clear need for novel,minimally-invasive tests to optimise immunosuppression and improve patient outcomes.An emerging biomarker in this‘‘precision medicine’‘liver transplantation field is that of donorspecific cell free DNA.In this review,we detail the background and methods of detecting this biomarker,examine its utility in liver transplantation and discuss future research directions that may be most impactful. | Tess McClure Su Kah Goh Daniel Cox Vijayaragavan Muralidharan Alexander Dobrovic Adam G Testro | 2020 | World Journal of Transplantation2020，10，11： | 2 |
| 6 | Final results of the Department of Defense multicenter breast lymphatic mapping trial显示文摘 | Shivers S Cox C Leight G | | 0，，： | 2 |
| 7 | Outcome in elderly patients undergoing primary coronary intervention for acute myocardial infarction: results from the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications ( CADILLAC ) trial 显示文摘 | Guagliumi G Stone G W Cox D A | 2004 | Circulation2004，110，12： | 1 |
| 8 | Mutations of the BRAF gene in human cancer显示文摘 | Davies H Bignell G R Cox C Stephens P Edkins S Clegg S et al | 2002 | Nature2002，417，： | 1 |
| 9 | 显示文摘 | Aller E Brown D S Cox G G | 1995 | J Org Chem1995，60，： | 1 |
| 10 | Definitive ab initio studies of model SN2 reactions CH3X+F-(X=F,Cl,OH,SH,NH2,PH2) 显示文摘 | JASON M G CHAEHO P COX R S | 2003 | Chem Eur J2003，9，： | 1 |
| 11 | HPV 16 DNA in normal and malignant cervical epithelium:implications for the aetiology and behaviour of cervical neoplasia显示文摘 | Meanwell CA Cox MF Blackledge G | 1987 | Lancet1987，1，8535： | 1 |
| 12 | Relationships Between Protein Composition and Mixograph and Loaf Characteristics in Wheat 显示文摘 | Dong H Sears R G Cox T S | 1992 | Cereal Chem1992，69，2： | 1 |
| 13 | The age of infection with varicella-zoster virus in St Lucia, West Indies 显示文摘 | Garnett G Cox M Bundy D | 1993 | Epi- demiolInfect1993，110，2： | 1 |
| 14 | A numerical model of fire in road tunnels显示文摘 | COX G KUMAR S | 1987 | Tunnels and tunnelling1987，19，3： | 1 |
| 15 | Does minimally invasive esophagectomy(MIE) provide for comparable oncologic outcomes to open techniques A systematic review显示文摘 | Dantoc M M Cox M R Esliek G D | 2012 | J Gastrointest Surg2012，16，： | 1 |
| 16 | Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1),in pheochromocytomas显示文摘 | Aguiar R C Cox G Pomeroy S L | 2001 | J Clin Endocrinol Metab2001，86，6： | 1 |
| 17 | The Numerical Evaluation of B-Splines 显示文摘 | Cox M G | 1972 | J INST Maths Application1972，，10： | 1 |
| 18 | C shaped canal configurations in mandibular molar显示文摘 | Cook H G 3rd Cox F L | 1979 | J Am Dent Assoc1979，99，5： | 1 |
| 19 | Prognostic significance of platelet and microvessel counts in operable non - small cell lung cancer显示文摘 | Cox G Walker RA Andi A | 2000 | Lung cancer2000，29，3： | 1 |
| 20 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
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