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| 1 | Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells显示文摘AIM:To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells. METHODS: Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTR lengths. RESULTS: Evaluation of adhesion results shows that H pylori pathogenic strain HP26695 has a significantly higher (P < 0.05) adhesion to all the cell lines and clones tested, when compared to the non-pathogenic strain HPTx30a. Bacteria showed a significantly higher (P < 0.05) adhesion to the GP202 cell line, when compared to the MKN45 cell line. Furthermore, both strains showed a significantly higher (P < 0.05) adhesion to GP202 clones with larger MUC1 VNTR domains. CONCLUSION: This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of theMUC1 VNTR domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa. | Natália R Costa Nuno Mendes Nuno T Marcos Celso A Reis Thomas Caffrey Michael A Hollingsworth Filipe Santos-Silva | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 2 | Contrast-induced acute kidney injury in kidney transplant recipients: A systematic review and meta-analysis显示文摘AIM To evaluate the incidence of contrast-induced acute kidney injury(CIAKI) in kidney transplant recipients. METHODS A literature search was performed using MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews from the inception of the databases through July 2016. Studies assessing the incidence of CIAKI in kidney transplant recipients were included. We applied a randomeffects model to estimate the incidence of CIAKI.RESULTS Six studies of 431 kidney transplant recipients were included in the analyses to assess the incidence of CIAKI in kidney transplant recipients. The estimated incidence of CIAKI and CIAKI-requiring dialysis were 9.6%(95%CI: 4.5%-16.3%) and 0.4%(95%CI: 0.0%-1.2%), respectively. A sensitivity analysis limited only to the studies that used low-osmolar or iso-osmolar contrast showed the estimated incidence of CIAKI was 8.0%(95%CI: 3.5%-14.2%). The estimated incidences of CIAKI in recipients who received contrast media with cardiac catheterization, other types of angiogram, and CT scan were 16.1%(95%CI: 6.6%-28.4%), 10.1%(95%CI: 4.2%-18.0%), and 6.1%(95%CI: 1.8%-12.4%), respectively. No graft losses were reported within 30 d post-contrast media administration. However, data on the effects of CIAKI on long-term graft function were limited.CONCLUSION The estimated incidence of CIAKI in kidney transplant recipients is 9.6%. The risk stratification should be considered based on allograft function, indication, and type of procedure. | Wisit Cheungpasitporn Charat Thongprayoon Michael A Mao Shennen A Mao Matthew R D'Costa Wonngarm Kittanamongkolchai Kianoush B Kashani | 2017 | World Journal of Transplantation2017，7，1： | 2 |
| 3 | Serum vitamin D content is associated with semen|parameters and serum testosterone levels in men显示文摘The present study aimed to evaluate the influence of serum vitamin D levels on semen quality and testosterone levels.This is a crosssectional study conducted at Androscience,Science and Innovation Center in Andrology and High-Complex Clinical and Andrology Laboratory in Sao Paulo,Brazil,with 508 male patients,aged 18-60 years,from 2007 to 2017.Seminal parameters and serum sexual hormones were correlated with serum vitamin D concentrations in 260 men selected by strict selection criteria.Patients were divided into normozoospermic group(NZG,n=124)and a group with seminal abnormalities(SAG,n=136).Evaluation included complete physical examination,past medical history,habits and lifestyle factors,two complete seminal analysis with sperm functional tests,serum levels of 25-hydroxy-vitamin D_(3)(25(OH)VD_(3)),total and free testosterone,luteinizing hormone(LH),follicle-stimulating hormone(FSH),sex hormone-binding globulin(SHBG),total cholesterol,homeostatic model assessment of insulin resistance(HOMA-IR)index,and karyotype.The mean concentration of 25(OH)VD_(3)was significantly lower in the SAG(P<0.001)and positively correlated with all baseline seminal parameters and total testosterone levels.In addition,serum vitamin D_(3)concentration was found to be positively correlated with sperm concentration(β=2.103;P<0.001),total number of spermatozoa with progressive motility(β=2.069;P=0.003),total number of motile spermatozoa(β=2.571;P=0.015),and strict morphology(β=0.056;P=0.006),regardless of other variables.This is the first comparative study to address the issue of serum vitamin D_(3)content between normozoospermic patients and those with sperm abnormalities.It clearly demonstrates a direct and positive relationship between serum vitamin D level and overall semen quality,male reproductive potential,and testosterone levels. | Inari M Ciccone Elaine MF Costa Juliana R Pariz Thiago A Teixeira Joel R Drevet Parviz Gharagozloo Robert J Aitken Jorge Hallak | 2021 | Asian Journal of Andrology2021，23，1： | 2 |
| 4 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 5 | Regiochemical control of monolignol radical coupling : a now paradigm for lignin and lignan biosynthesis显示文摘 | Gang D R Costa M A Fujita M | 1999 | Chem Biol1999，6，3： | 1 |
| 6 | Characteriza- tion of Fiber Laser Welds in X100 Pipeline Steel 显示文摘 | Miranda R Costa A Quintino L | 2009 | Materials and Design2009，30，7： | 1 |
| 7 | Determination of triglycer- ides in human plasma using near-infrared spectroscopy and multivariate calibration methods 显示文摘 | da Costa Filho P A Poppi R J | 2001 | Analytica Chimica Acta2001，446，12： | 1 |
| 8 | A Control-volume based Finite Element Method for Three-dimensional Incompressible Turbulent Fluid Flow, Heat Transfer and Related Phenomena 显示文摘 | Costa V A F Oliveira L A Figueiredo A R | 1995 | Int J Numer Mesh Fluid1995，21，5： | 1 |
| 9 | Obliquity-correction imaging condition for reverse time migration显示文摘 | Costa J C Silva Neto F A Alcantara M R M | 2009 | Geophysics2009，74，3： | 1 |
| 10 | Water resources planning - a research program显示文摘 | SANTOS M A COSTA J R | 1987 | Water Science Technology1987，19，9： | 1 |
| 11 | Xylitol production from eucalyptus wood hydrolysates extracted with organic solvents显示文摘 | Costa Queiroz R H Melchior E de Souza A M | 1997 | Process Biochemistry1997，32，7： | 1 |
| 12 | Activation of the NLRP3 inflammasome by group B streptococci显示文摘 | Costa A Gupta R Signorino G | 2012 | J Immunol2012，188，4： | 1 |
| 13 | Structural effects of WO3 incorporation on USY zeolite and applica- tion to free fatty acids esterification显示文摘 | Costa A A Braga P R S Macedo J L | 2012 | Microporous and Mesoporous Materials2012，147，1： | 1 |
| 14 | Clinical features and outcome of patiens with non-small-cell lung cancer who harbor EML4-ALK显示文摘 | Shaw A T Yeap B Y Mino-Kenudson M Digumarthy S R Costa D B Heist R S | 2009 | J Clin Oncol2009，27，： | 1 |
| 15 | Analysis of carotenoids in vegetable and plasma samples : a review 显示文摘 | Quiros A R Costa HS | 2006 | Journal of Food Composition and Analysis2006，19，23： | 1 |
| 16 | A geometric interpretation for transmission real losses minimization through the optimal power flow and its influence on voltage collapse显示文摘 | Alves D A Costa G R M | 2002 | Electric Power Systems Research2002，62，： | 1 |
| 17 | Oil Wastes as Unconventional Substrates for Rhamnolipid Biosurfactant Production by Pseudomonas aeruginosa LBI显示文摘 | Nitschke M Costa S G V A O Haddad R | 2005 | Biotechnol Prog2005，21，： | 1 |
| 18 | Welding with high power fiber lasers-A preliminary study显示文摘 | Quintino L Costa A Miranda R | 2007 | Marterials & Design2007，28，4： | 1 |
| 19 | Pigments in the fruit of red-fleshed kiwifruit (Actinidia chinensis and Actinidia deliciosa) 显示文摘 | Montefiori M McGhie T K Costa G Ferguson A R | 2005 | J Agric Food Chem2005，53，24： | 1 |
| 20 | Optimization of the physical refining of sunflower oil concerning the final contents of trans fatty acids显示文摘 | CERIANI R COSTA A MEIRELLES A | 2008 | Industrial and Engineering Chemistry Research2008，47，3： | 1 |
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