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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 3 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 4 | Multimodal integration--a statistical view 显示文摘 | Wu L Z Oviatt S L Cohen P R | 1999 | IEEE Transactions on Multimedia1999，1，4： | 1 |
| 5 | Fruit and vegetable intakes and prostate cancer risk 显示文摘 | Cohen J H Kristal A R Stanford J L | 2000 | J Natl Cancer Inst2000，92，1： | 1 |
| 6 | Modulation of the prospective and retrospective components of memory for intentions in younger and older adults 显示文摘 | COHEN A L WEST R CRAIK F | 2001 | Aging Neuropsychol Cognition2001，，8： | 1 |
| 7 | New- born Wet and Soiled Diaper Counts and Timing of Onset of Lactation as Indicators of Breasffeeding Inadequacy显示文摘 | Nommsen-Rivers L A Heinig M J Cohen R J | 2008 | J Hum Lact2008，24，1： | 1 |
| 8 | Improved tech- niques for lower bounds for odd perfect numbors显示文摘 | Brent R P Cohen G L te Riele H J J | 1991 | Math Comput1991，196，57： | 1 |
| 9 | The role of social structure in the maintenance of cooperative regimes显示文摘 | Riolo L Alexlrod R | 2001 | Rationality and Society2001，13，1： | 1 |
| 10 | Clinical significance of insulin-like growth factor binding proteins( IGFBPs )显示文摘 | Levitt Katz L E Rosenfeld R G Pinchas Cohen S | 1995 | Endocrinologist1995，5，： | 1 |
| 11 | Vascular endothelial growth factorin Alzheimer's disease and experimeutal Cerebral ischemia显示文摘 | Kalaria R N Cohen D L Premkumar D R | 1998 | Brain Res Mol Brain Res1998，621，： | 1 |
| 12 | Complications of cochlear implant surgery显示文摘 | HOFFMAN R A COHEN N L | 1995 | Ann Otol Rhinol Laryngol (Suppl)1995，166，： | 1 |
| 13 | The AETG System:An Approach to Test Based on Combinatorial Design 显示文摘 | Cohen D M Dalal S R Fredman M L | 1997 | IEEE Transactions on Software Engineering1997，23，7： | 1 |
| 14 | Bayesian statistical analysis of protein sidechain rotamer preferences显示文摘 | Dunbrack R L Jr Cohen F E | 1997 | Protein Sci1997，6，8： | 1 |
| 15 | Toughenability of nylon-6 with CaCO3 filler particles: new findings and general principles显示文摘 | Wilbrink M W L Argon A S Cohen R E | 2001 | Polymer2001，42，10： | 1 |
| 16 | Onset and characteristics of the midcycle surge in bioactive and immunoactive luteinizing 显示文摘 | FRITZ M A MCLACHLAN R L COHEN N L | 2003 | Fert Sterl2003，12，2： | 1 |
| 17 | 查看详情显示文摘 | Cohen S R Rapoport L Ponomarev E A | | 0，，： | 1 |
| 18 | Anti-VEGF therapy (bevacizumab) for sulfurmustard-induced comeal neovascularization associated withdelayed limbal stem cell deficiency in rabbits显示文摘 | KADAE T AMIR A COHEN L COHEN M SAHAR R GUT-MAN H | 2014 | Curr Eye2014，39，5： | 1 |
| 19 | J Org Chem显示文摘 | Rajecwama W G Labroo R B Cohen L A | 1999 | 64(4):1369-13711999，64，4： | 1 |
| 20 | Neonatal streptozotocin-induced glu- cose intolerance: different consequences in Lyon normotensive and hypertensive rats显示文摘 | Emonnot L Cohen R Lo M | 2007 | J Hypertens2007，25，2： | 1 |
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