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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 3 | Complexities for generalized models of self-assembly显示文摘 | Aggarwal G Cheng Q Goldwasser M H | 2005 | SIAM Journal on Computing2005，34，14： | 1 |
| 4 | Monitoring process mean and variability with one EWMA chart 显示文摘 | Chen G M Cheng S W Xie H S | 2001 | Journal of Quality Technology2001，33，2： | 1 |
| 5 | Electron microscopic studies of the morphogenesis of duck enteritis virus显示文摘 | Yuan G P Cheng A C Wang M S | 2005 | Avian Dis2005，49，1： | 1 |
| 6 | Study on photocatalytic degradation of several volatile organic compounds显示文摘 | Zuo G M Cheng Z X Chen H | 2006 | Journal of hazardous materials2006，128，2： | 1 |
| 7 | Nitrogen vacancy-promoted photocatalytic activity of graphitic carbon nitride显示文摘 | Niu P Liu G Cheng H M | 2012 | The Journal of Physical Chemistry C2012，116，11： | 1 |
| 8 | GmDREB2 ya soy-bean DRE-binding transcription factor conferred droughtand high-salt tolerance in transgenic plants显示文摘 | Chen M Wang Q Y Cheng X G^ | 2007 | Biochemi-cal and Biophysical Research Communications2007，353，2： | 1 |
| 9 | Study on physical properties and nerve cell affinity of composite films from chitosan and gelatin solutions显示文摘 | CHENG M Y DENG J G YANG F | 2003 | Biomaterials2003，24，： | 1 |
| 10 | PEG-scutellarin prodrugs:Synthesis,water solubility and protective effect on cerebral ischemia/reperfusion injury显示文摘 | Lu J Cheng C M Zhao X G | 2010 | Eur J Med Chem2010，45，5： | 1 |
| 11 | Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function显示文摘 | Cheng G Z Zhang W Z Sun M | 2008 | J Biol Chem2008，283，14： | 1 |
| 12 | Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model 显示文摘 | Cheng G Arima M Honda K | 2002 | Am J Respir Crit Care Med2002，166，3： | 1 |
| 13 | Transgenic rice with a synthetic crylAb gene from Bacillus thuringiensis is highly resistant to eight lepidopteran insects显示文摘 | Shu Q Y Ye G Y Cui H R Cheng X Xiang Y Wu D Gao M Xia Y Hu C Sardana R Altosaar I | 2000 | Mol Breed2000，，6： | 1 |
| 14 | Somatic hybridization between common wheat and Italian ryegrass 显示文摘 | Cheng A X Xia G M | 2004 | Plant Science2004，166，5： | 1 |
| 15 | The effect of delipidated deglycolipidated(DDMV) and heat-killed Mycobacterium vaccae in asthma显示文摘 | Shirtcliffe PM Easthope SE ChengS Weatherall M Tan PL LeGros G | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 16 | Heterogeneous catalytic wet peroxide oxidation of phenol over delaminated Fe-Ti-PILC employing microwave irradiation显示文摘 | Mei J G Yu S M Cheng J | 2004 | Catalysis Communications2004，5，： | 1 |
| 17 | Anti-vascular per- meability of the cleaved reactive center loop within the earboxyl-terminal domain of C1 inhibitor显示文摘 | Cheng Z D Liu M Y Chen G | 2008 | Mol Im- munol2008，45，6： | 1 |
| 18 | Direct catalytic conversion of cellulose into ethylene glycol using nickel-promoted tungsten carbide catalysts显示文摘 | JI N ZHANG T ZHENG M Y WANG A Q WANG H WANG X D CHENG J G | 2008 | Angew Chem2008，120，44： | 1 |
| 19 | Simulation of a LHP- based thermal Control System Under Orbital Environment显示文摘 | Xin G M N Chen Y Cheng L | 2009 | Applied Thermal Engineering2009，29，： | 1 |
| 20 | Decentralized Robust Adaptive Control for the Multiagent System Consensus Problem Using Neural Networks显示文摘 | Hou Z G Cheng L Tan M | | 0，，39： | 1 |
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