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| 1 | Vascular endothelial growth factor receptor 2(VEGFR-2) plays a key role in vasculogenic mimicry formation,neovascularization and tumor initiation by Glioma stem-like cells显示文摘Human glioblastomas(GBM)are thought to be initiated by glioma stem-like cells(GSLCs).GSLCs also participate in tumor neovascularization by transdifferentiating into vascular endothelial cells.Here,we report a critical role of GSLCs in the formation of vasculogenic mimicry(VM),which defines channels lined by tumor cells to supply nutrients to early growing tumors and | Yao X Ping Y Liu Y Chen K Yoshimura T Liu M Gong W Chen C Niu Q Guo D Zhang X Wang JM Bian X | 2013 | 中国神经肿瘤杂志2013，11，3： | 23 |
| 2 | Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression显示文摘 | Chen T Guo J Yang M Han C Zhang M Chen W Liu Q Wang J Cao X | 2005 | 第二军医大学学报2005，26，11： | 11 |
| 3 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 4 | 相对骨骼肌质量与非酒精性脂肪性肝病的关系:一项系统评价和荟萃分析显示文摘【据《Hepatol Int》2020年1月报道】题:相对骨骼肌质量与非酒精性脂肪性肝病的关系:一项系统评价和荟萃分析(作者Cai C等)非酒精性脂肪性肝病(NAFLD)已逐渐成为全世界最常见的慢性肝病之一。越来越多的证据表明,低骨骼肌质量指数(SMI)可能在NAFLD的发展中起作用。该研究目的是探讨量化SMI、肌少症与NAFLD发生和发展之间的关联。作者系统地检索了PubMed、Embase、Web of Science和Cochrane图书馆中相关的英语研究,时间截止至2018年12月20日。 | 蔡昌洲 虞朝辉 CAI C SONG X CHEN Y | 2020 | 临床肝胆病杂志2020，36，3： | 7 |
| 5 | 血浆7-酮胆固醇与冠状动脉疾病患者心血管结局和总死亡率的关系显示文摘7-酮胆固醇(7-ketocholesterol,7-KC)是胆固醇氧化产物的一种形式,在动物动脉粥样硬化模型的形成中起重要作用。该文研究人员试图确定循环7-KC与稳定型冠状动脉疾病(coronary artery disease,CAD)患者的临床心血管结局和总死亡率的关系。 | 刘莉 叶鹏 Song J Wang D Chen H Huang X Zhong Y Jiang N Chen C Xia M | 2017 | 中华高血压杂志2017，25，6： | 4 |
| 6 | 基于工作地点的分组干预对高血压控制的影响:一项随机临床研究显示文摘基于工作地点的干预可能为一种管理高血压的有效方法。但是目前缺少针对中国工作人群高血压控制情况的研究。本研究旨在评估基于工作地点的多组分别干预策略对改善血压控制的影响。研究设计及受试者:研究者在2013年1月至2014年12月于中国20个城区的60个工作地点进行了一系列高血压管理的随机临床试验。工作地点随机分为干预组(n=40)和对照组(n=20)。每个工作地点的受试者都需要完成一项横断面调查。 | 袁源(摘译) 叶鹏(审校) Wang Z Wang X Shen Y Li S Chen Z Zheng C Kang Y Jiang L Hao G Chang C Gao R | 2020 | 中华高血压杂志2020，28，6： | 3 |
| 7 | Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis显示文摘Cyclin B1 是在脊椎动物控制房间周期前进的关键规章的蛋白质。Cyclin B1 绑 CDK1, cyclin 依赖的 kinase 催化子单元,形成通过关键蛋白质的磷酸化安排有丝分裂的建筑群。Cyclin B1 两个都调整 CDK1 和它的潜水艇的激活细胞的本地化,它可能为底层选择批评。这里,我们证明 cyclin B1 被专注于 kinetochore 的外部板在专业版期间中期。这本地化要求蛋白质的 cyclin 盒子区域。Cyclin B1 被微导管附件从单个 kinetochores 代替到锭子杆到 kinetochores,并且这排水量依赖于 dynein/dynactin 建筑群。由基于向量的 siRNA 的 B1 引起在 kinetochores 和微导管之间的低效的附件的 cyclin 的弄空,和染色体排列背叛,并且推迟后期的发作。在它贡献微导管的正确附件到 kinetochores 和染色体的有效排列的地方,我们断定 cyclin B1 在职业人员中期期间在 kinetochores 积累,通过由 cyclin B1-CDK1 的特定的底层的局部性的磷酸化最可能。当微导管附件被完成, Cyclin B1 然后从每 kinetochore 被搬运,并且这本地化可以重定向 cyclin B1-CDK1 的活动并且在锭子集会检查点的激活贡献。 | Chen,Q Zhang,X Jiang,Q Clarke,PR Zhang,C | 2008 | Cell Research2008，18，2： | 3 |
| 8 | 中国成年女性初潮年龄与高血压风险的关系:大型国家代表性群体研究结果显示文摘本研究纳入中国高血压调查中年龄≥18岁的女性234867例,旨在探索中国成年女性初潮年龄与高血压风险的相关性。参与者被要求完成标准问卷,血压测量和体格检查由经过培训的医务人员完成。采用Spearman相关性分析探索初潮年龄和其他个体特征的相关性。采用logistic回归根据初潮年龄计算高血压发生的OR。结果显示,中国女性平均初潮年龄为14.8岁。 | 袁源(摘译) 郑武洪(审校) Chen L Zhang L Chen Z Wang X Zheng C Kang Y Zhou H Wang Z Gao R | 2021 | 中华高血压杂志2021，29，10： | 3 |
| 9 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 10 | 欧洲城市绿地在老年人护理设施中的作用显示文摘城市绿地(UGS)对城市人类福祉的重要性日益得到认可,但大部分研究只针对公园、社区花园、城市森林等绿地,而缺乏对不同人群的城市绿地需求与使用情况的考虑,也未能将城市绿地与社会基础设施联系起来。老龄化已成为目前全球性的人口发展趋势。已有研究发现,到城市绿地的良好可达性对于居住在绿地周围步行距离中的老人而言具有正面的健康影响,并且可以增加他们的寿命。 | ARTMANN M CHEN X IOJA C | 2017 | 城市规划学刊2017，，5： | 3 |
| 11 | The Novel Mechanical Property of Tongue of a Woodpecker显示文摘Biomaterials such as bone,teeth,nacre and silk are known to have superior mechanical properties due to their specificnanocomposite structures.Here we report that the woodpecker’s tongue exhibits a novel strength and flexibility due to its specialcomposite micro/nanostructure.The tongue consists of a flexible cartilage-and-bone skeleton covered with a thin layer tissue ofhigh strength and elasticity.At the interface between the cartilage-and-bone skeleton and the tissue layer,there is a hierarchicalfiber-typed connection.It is this special design of the tongue that makes the woodpeckers efficient in catching the insects insidetrees.The special micro/nanostructures of the woodpecker’s tongue show us a potential method to enhance the interfacialconnection between soft and hard material layers for bio-inspired composite system designs. | P Zhou X Q Kong C W Wu Z Chen | 2009 | Journal of Bionic Engineering2009，6，3： | 3 |
| 12 | 纳米光子结构软膜紫外光固化纳米压印(英文)显示文摘紫外光固化纳米压印是实现纳米结构批量复制的一种新技术.其特点是低成本和高分辨,而且可以达到极高的套刻精度.为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板.其母版图案可由高分辨率电子束曝光和反应离子刻蚀的方法在硅片基底上获得,然后用浇注的方法将图案转移到PDMS上.本实验特别发展了紫外光固化纳米压印适用于软膜压印的双层膜图型转移技术.该双层膜由廉价的光胶和聚甲基丙烯酸甲脂(PMMA)构成.对光胶层的压印可用普通的光学曝光仪实现.然后再将图案用反应离子刻蚀的方法转移到PMMA层中.为了证明方案的可行性,在两种不同材料的半导体基片上压印了三角晶格的光子晶体和准晶结构的图案,并用剥离的方法将它们转移到金属薄膜上,最后成功地进行了硅片刻蚀实验.相信这一纳米制做方法对大面积纳米光子结构和光学集成芯片的制造是普遍适用的. | SHI J WANG Z M BAO K PEROZ C BELOTTI M XU L P LUO C X SUN M H ZHANG B JI H OUYANG Q CHEN Y | 2006 | 纳米技术与精密工程2006，4，3： | 2 |
| 13 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 14 | Ginsenosides protect puonary vascular endothelium against free radical-induced injury 显示文摘 | Kim H Chen X Gillis C N | 1992 | Biochem Biophys Res Coun1992，189，： | 2 |
| 15 | In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells显示文摘 | Chen J Wang C Lu S Wu J Guo X Duan C Dong L Song Y Zhang J Jing D Wu L Ding J Li D | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 16 | A study of the cohesion of dairy powders 显示文摘 | Rennie P R Chen X D Hargreaves C Mackereth A R | 1999 | Food Enging1999，39，2： | 1 |
| 17 | Cloning and expression of a mannanase gene from Erwinia carotovora CXJZ95-198 显示文摘 | ZHANG Y X LIU Z C CHEN X B | 2007 | Annals of Microbiology2007，57，4： | 1 |
| 18 | Degradation of dye pollutants by immobilized polyoxometalate with H2O2 under visible-light irradiation显示文摘 | Lei P X Chen C C Yang J el al | 2005 | Environmental Science and Technology2005，39，21： | 1 |
| 19 | A conformationally sensitive GHR antibody : impact on GH signaling and GHR proteolysis显示文摘 | Jiang J Wang X He K Li X Chen C M Sayeski P P Waters M J Frank S J | 2004 | Mol Endocrinol2004，18，12： | 1 |
| 20 | Investigation of the thermal mechanical properties of a plasmasprayed nanostructured zirconia coating显示文摘 | Chen H Zhou X M Ding C X | 2003 | Journal of the European Ceramics Society2003，23，： | 1 |
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