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| 1 | Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNA (Ser(UCN)) genes in two Chinese families显示文摘 | Zhu Y Qian YP Tang XW Wang JD Yang L Liao ZS Li RH Ji JZ Li ZY Chen JF Choo DI Lu JX Guan MX | 2006 | 中国生物学文摘2006，20，4： | 16 |
| 2 | Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration显示文摘INTRODUCTIONThe liver is one of the organs,which have potentialregenerative capability in mammalian animal.The study of the canine model indicated that theliver could regenerate to original size after 70%hepatectomy in only two weeks.So it is a hotresearch topic for the cellular and molecularmechanism of liver regeneration. | Cheng J Zhong YW Liu Y Dong J Yang JZ Chen JM | 2000 | World Journal of Gastroenterology2000，6，2： | 13 |
| 3 | Primary porcine hepatocytes with portal vein serum cultured on microcarriers or in spheroidal aggregates显示文摘AIM To develop a culture mode providingdurable biomaterials with high yields andactivities used in bioartificial liver.METHODS Hepatocytes were isolated from awhole pig liver by Seglen’s method of orthotopicperfusion with collagenase.In culture onmicrocarriers,primary porcine hepatocyteswere inoculated at a concentration of 5×10~7/mLinto the static culture systems containing 2 g/LCytodex-3,then supplemented with 100 mL/Lfetal calf serum(FCS)or 100 mL/L porcineportal vein serum(PPVS)respectively.Inspheroidal aggregate culture hepatocytes wereinoculated into 100 mL siliconized flasks at aconcentration of 5.0×10~6/mL.RESULTS In culture on microcarriershepatocytes tended to aggregate on Cytodex-3obviously after being inoculated.Typical multi-cellular aggregated spheroids could be found inthe two systems 24 h-48 h after hepatocyteswere cultured.The morphological charact-eristics and synthetic functions were maintainedfor 5 wk in FCS culture system and 8 wk in PPVSculture system.In spheroidal aggregate cultureabout 80%-90% isolated hepatocytes becameaggregated spheroids 24h after cultured insuspension and mean diameter of the spheroidswas 100μm.The relationship among thehepatocytes resembled that in the liver in vivo.Synthetic functions of albumin and urea of the spheroids were twice those of hepatocytescultured on monolayers.CONCLUSION As high-yields and high-activitymodes of culture on microcarriers or inspheroidal aggregate culture with portal veinserum are promising to provide biomaterials forbioartificial liver(BAL)efficiently. | Gao Y Hu HZ Chen K Yang JZ | 2000 | World Journal of Gastroenterology2000，6，3： | 6 |
| 4 | Cyclic adenosine 3',5'-monophosphate induces differentiation of mouse embryonic stem cells into cardiomyocytes显示文摘 | Chen Y Shao JZ Xiang LX Guo J Zhou Q J Yao X Dai LC Lu YL | 2006 | 中国生物学文摘2006，20，7： | 5 |
| 5 | Quantum chemical studies on antimalarial of artemisinin (qinghaosu) derivatives显示文摘In this paper theoretical studies were performed on artemisinin (qinghaosu) derivatives with semiempirical quantum chemical methods AMI and PM3. The antimalarial activity -logC has an obvious correlation with the net charge of C(16) and bond orders of bonds O(1)-C(10), O(2)-C(6), O(1)-O(2) and O(5)-C(16). According to the calculation results, we derived structure-activity relationship, presented the probable pharmacophore of qinghaosu derivatives and the interaction fashion between the drugs and the plasmodium receptor. | JIANG, HL CHEN, KX TANG, Y CHEN, JZ JI, RY | 1995 | Chinese Journal of Chemistry1995，13，2： | 5 |
| 6 | 3D-QSAR STUDY ON HUPERZINE A ANALOGS WITH MOLECULAR MODELING AND COMPARATIVE MOLECULAR FIELD ANALYSIS(COMFA) METHODS显示文摘3D-QSARSTUDYONHUPERZINEAANALOGSWITHMOLECULARMODELINGANDCOMPARATIVEMOLECULARFIELDANALYSIS(COMFA)METHODS￥HuaLiangJIANG;KaiXianC... | Jiang, HL Chen, KX Chen, JZ Tang, Y Wang, QM Li, Q Shen, X Ji, RY | 1996 | Chinese Chemical Letters1996，7，3： | 2 |
| 7 | CYCLIC VOLTAMMETRY STUDY ON ANTIMALARIAL MECHANISM OF ARTEMISININ(QINGHAOSU)DERIVATIVES显示文摘CYCLICVOLTAMMETRYSTUDYONANTIMALARIALMECHANISMOFARTEMISININ(QINGHAOSU)DERIVATIVES￥HuaLiangJIANG;KaiXianCHEN;YunTANG;JianZhongC... | Jiang, HL Chen, KX Tang, Y Chen, JZ Li, Y Wang, QM Li, Q Ji, RY Zhuang, QK | 1996 | Chinese Chemical Letters1996，7，7： | 2 |
| 8 | Cloning and expression of a novel tinoblastoma binding protein cDNA,RBBP10显示文摘 | Chen JZ Yang QS Wang S | 2002 | Biochem Genet2002，40，78： | 1 |
| 9 | Protective effect of oleanolic acid against beta cell dysfunction and mitochondrial apoptosis:crucial role of ERK-NRF2 signaling pathway显示文摘 | Wang X Chen HL Liu JZ | 2013 | J Biol Regul Homeost Agents2013，27，1： | 1 |
| 10 | RablO and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes显示文摘 | Chen Y Wang Y Zhang JZ | 2012 | J Cell Biol2012，198，4： | 1 |
| 11 | Comparison of the effects of laparoscopic hernia repair and lichtenstein tension- free hernia repair显示文摘 | WANG WJ CHEN JZ FANG Q | 2013 | J Laparoendosc Adv Surg Tech A2013，23，4： | 1 |
| 12 | Effects of losartan on expression of connexins at the early stage of atherosclerosis in rabbits显示文摘 | Ruan LM Cai W Chen JZ | | 0，，02： | 1 |
| 13 | Roles of rifampicin in drug-drug interactions:underlying molecular mechanisms involving the nuclear pregnane X receptor Ann Clin Microbiol Antimicrob显示文摘 | Chen JZ Raymond K | 2006 | Ann Clin Microbiol Antimicrob2006，15，3： | 1 |
| 14 | Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia显示文摘 | Chen JZ Zhang FR Tao QM | 2004 | Clin Sci2004，107，3： | 1 |
| 15 | Efficacy and safety of intense pulsed light in treatment of melasma in Chinese patients 显示文摘 | Li YH Chen JZ Wei HC | 2008 | Dermatol Surg2008，34，5： | 1 |
| 16 | Molecular interactions in rotavirus assembly and uneoating seen by high-resolution cryo- EM 显示文摘 | Chen JZ Settembre EC Aoki ST | 2009 | Proc Natl Acad Sei USA2009，106，10： | 1 |
| 17 | A five-gene signature as apotential predictor of metastasis and survival in colorectal cancer显示文摘 | Hao JM Chen JZ Sui HM | 2010 | J Pathol2010，220，4： | 1 |
| 18 | CRH receptor type 1 mediates continual hypoxia-induced changes of immunoreactive prolactin and prolactin mRNA expression in rat pituitary 显示文摘 | Xu JF Chen XQ Du JZ | 2006 | Horm Behav2006，49，2： | 1 |
| 19 | A split-face study of intense pulsed light on photoaging skin in Chinese population显示文摘 | Li YH Wu Y Chen JZ | 2010 | Lasers Surg Med2010，42，2： | 1 |
| 20 | Neuroprotective effects of (-)-Epigallocatechin-3-gallate(EGCG)on paraquat-induced apoptosis in PC12 cells显示文摘 | HOU RR CHEN JZ CHEN H et ol | 2008 | Cell Bio Int2008，，32： | 1 |
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