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| 1 | 欧洲呼吸学会和欧洲胸外科医师学会恶性胸膜间皮瘤诊疗指南显示文摘恶性胸膜间皮瘤(malignant pleural mesothelioma,MPM)是一种罕见肿瘤,但发病率正逐渐上升,且预后较差。2008年,欧洲呼吸学会(European Respiratory Society,ERS)和欧洲胸外科医师学会(European Society of Tho-racic Surgeons,ESTS)特别工作组召集各方专家计划制定MPM诊治经验及更新指南。为了使MPM得到及时准确的诊断,专家推荐对患者实施胸腔镜检查,有手术禁忌和胸腔粘连的病例除外。约10%的病例采用标准染色方法无法获得满意的结果。因此我们推荐在胸膜活检的基础上,采用特异性免疫组化标志物。由于目前缺乏一个统一的、切实有效的分期系统,我们推荐应用最新的TNM分期,并且提出三个阶段的治疗前评估。在MPM的治疗中,患者的体力状态评分和组织亚型是目前唯一的、具有重要临床价值的预后因素。在临床试验中,应对其它潜在因素进行初步探讨并予以报道。MPM对化疗高度耐受,仅有少数患者可接受根治性手术。本文对新的治疗方法和策略进行了综述。目前由于最佳综合治疗的资料有限,适合采用多种方案联合治疗策略的患者应被纳入专业机构的前瞻性试验中。 | A. Scherpereel P. Astoul P. Baas T. Berghmans H. Clayson P. de Vuyst H. Dienemann F. Galateau-Salle C. Hennequin G. Hillerdal C. Le Pe'choux L. Mutti J-C. Pairon R. Stahel P. van Houtte J. van Meerbeeck D. Waller W. Weder 宋作庆 徐萧洪 | 2010 | 中国肺癌杂志2010，，10： | 56 |
| 2 | Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis显示文摘AIM:To assess expression of matrix metalloproteinases 2(MMP2)and MMP9 in gastric cancer,superficial gastritis and normal mucosa,and to measure metalloproteinase activity.METHODS:MMP2 and MMP9 mRNA expression was determined by quantitative real-time polymerase chain reaction.Normalization was carried out using three different factors.Proteins were analyzed by quantitative gelatin zymography(qGZ).RESULTS:18S ribosomal RNA(18SRNA)was very highly expressed,while hypoxanthine ribosyltransferase-1(HPRT-1)was moderately expressed.MMP2 was highly expressed,while MMP9 was not detected or lowly expressed in normal tissues,moderately or highly expressed in gastritis and highly expressed in cancer.Relative expression of 18SRNA and HPRT-1 showed no significant differences.Significant differences in MMP2 and MMP9 were found between cancer and normal tissue,but not between gastritis and normal tissue.Absolute quantification of MMP9 echoed this pattern,but differential expression of MMP2 proved conflictive.Analysis by qGZ indicated significant differences between cancer and normal tissue in MMP-2,total MMP-9,250 and 110 kDa bands.CONCLUSION:MMP9 expression is enhanced in gastric cancer compared to normal mucosa;interpretation of differential expression of MMP2 is difficult to establish. | Clara Luz Sampieri Sol de la Pea Mariana Ochoa-Lara Roberto Zenteno-Cuevas Kenneth León-Córdoba | 2010 | World Journal of Gastroenterology2010，16，12： | 46 |
| 3 | World Gastroenterology Organisation Global Guidelines: Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis显示文摘 | Douglas R. LaBrecque Zaigham Abbas Frank Anania Peter Ferenci Aamir G. Khan Khean-Lee Goh Saeed S. Hamid Vasily Isakov Maribel Lizarzabal Manuel M. Pe?aranda Juan F.R. Ramos Shiv Sarin Davor Stimac Alan B.R. Thomson Muhammed Umar Justus Krabshuis Anton Le | 2014 | Journal of Clinical Gastroenterology2014，，6： | 3 |
| 4 | Presurgical nasoalveolar molding in infants with cleft lip and palate显示文摘 | Grayson BH Santiago PE Brecht LE | 1999 | Cleft Palate Craniofac J1999，36，6： | 1 |
| 5 | Homucysteine and abdominal aortic aneurysms显示文摘 | Moroz P Le MT Norman PE | 2007 | ANZ J Surg2007，77，5： | 1 |
| 6 | Local moderate magnetically induced hyperthermia using an implant formed in situ in a mouse tumor model显示文摘 | Le Renard PE Buchegger F Petri-Fink A | 2009 | Int J Hyperthermia2009，25，3： | 1 |
| 7 | Pain-temperature lelation in the application of local anaesthesia显示文摘 | Perula LA Fiaja LE | 1993 | Rr J plast surg1993，46，1： | 1 |
| 8 | Clinical pharmacokinetics of endocrine ,agents used in advanced breast cancer显示文摘 | Lcnning PE LE Lundgren S Kvinnsland S | 1992 | Clin Pharma- cokinet1992，22，5： | 1 |
| 9 | Presurgical nasoalveolar molding in infants with cleft lip and palate 显示文摘 | Grayson BH Santiago PE Brecht LE | 1999 | Cleft Palate Craniofac J1999，36，6： | 1 |
| 10 | Presurgical nasoalveolar molding in infants with cleft lip and palate显示文摘 | Grayson BH Santiago PE Brecht LE | | 0，，06： | 1 |
| 11 | Tau oligomers and aggregation in Alzheimer’s disease显示文摘 | Marco A.Meraz‐Ríos Karla I.Lira‐De León VictoriaCampos‐Pe?a Martha A.De Anda‐Hernández RaúlMena‐López | 2010 | Journal of Neurochemistry2010，，6： | 1 |
| 12 | Presurgicalnasoalveolar molding in infants with cleft lip and palate显示文摘 | Grayson BH Santiago PE Brecht LE | 1999 | Cleft Palate Craniofac J1999，36，6： | 1 |
| 13 | Quality of life following femoral head-neck osteochondroplasty for femoroacetabular impingement显示文摘 | Beaule PE Le Duff M J Zaragoza E | 2007 | J Bone Joint Surg (Am)2007，89，6： | 1 |
| 14 | Quality of life following femoral head-neck osteochondroplasty for femoroacetabular impingement显示文摘 | Beaulé PE Le Duff M J Zaragoza E | 2007 | J Bone Joint Surg Am2007，89，4： | 1 |
| 15 | Inspiratory muscle training during pulmonary rehabilitation in chronic obstructive pulmonary disease显示文摘 | Beaumont M Mialon P Ber-Moy C Le Lochon C Pe?ran L Pichon R Gut-Gobert C Leroyer C Morelot-Panzini C Couturaud F | 2015 | Chronic Respiratory Disease2015，，4： | 1 |
| 16 | Local moderate magnetically induced hyperthermia using an implant formed in situ in a mouse tumor model显示文摘 | LE RENARD PE BUCHEGGER F PETRI-FINK A | 2009 | Int J Hyperthermia2009，25，3： | 1 |
| 17 | Early intervention in severe head injury: long-term benefits of a formalized program 显示文摘 | Mackay LE Bemstein BA Chapman PE | 1992 | Arch Phy Med Rehabil1992，73，： | 1 |
| 18 | Presurgical nasoalveolar molding in infants with cleft lip and palate显示文摘 | Grayson BH Santiago PE Brecht LE | | 0，，06： | 1 |
| 19 | The economic burden of depression in 1990显示文摘 | Greenberg PE Stiglin LE Finkelstein SN | 1993 | J Clin Psychiatry1993，54，11： | 1 |
| 20 | Influence of recasting on the castability of copper-aluminum al oys显示文摘 | Bombonatti PE Barros LE Scaranelo RM | | 0，，01： | 1 |
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