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| 1 | Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy显示文摘AIM: To evaluate the implication of substitutions in the hepatitis C virus (HCV) non-structural 5A (NS5A) protein in the resistance of HCV during mono-interferon (IFN) or combined IFN-ribavirin (IFN-R) therapy. Although NS5A has been reported to interact with the HCV RNA- dependent RNA polymerase, NS5B, as well as with many cellular proteins, the function of NS5A in the life cycle of HCV remains unclear. METHODS: HCV quasispecies were studied by clon- ing and sequencing of sequential isolates from patients infected by HCV genotype 1b. Patients were treated by IFN-α2b for 3 mo followed by IFN-α2b alone or com- bined IFN-R therapy for 9 additional months. Patients were categorized intro two groups based on their re- sponse to the treatments: 7 with sustained virological re- sponse (SVR) (quasispecies = 150) and 3 non-respond- ers (NR) to IFN-R (quasispecies = 106). RESULTS: Prior to treatment, SVR patients displayed a lower complexity of quasispecies than NR patients. Most patients had a decrease in the complexity of quasispe- cies during therapy. Analysis of amino acids substitu- tions showed that the degree of the complexity of the interferon sensitivity-determining region (ISDR) and the V3 domain of NS5A protein was able to discriminate thetwo groups of patients. Moreover, SVR patients displayed more variability in the NS5A region than NR patients. CONCLUSION: These results suggest that detailed mo- lecular analysis of the NS5A region may be important for understanding its function in IFN response during HCV 1b infection. | Pascal Veillon Christopher Payan Hélène Le Guillou-Guillemette Catherine Gaudy Franoise Lunel | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | 外耦合布拉格光栅 5μm量子级联激光器(英文)显示文摘窄带宽的 Al Ga As/ Ga As布拉格光栅耦合到 In P的半导体量子级联激光器从而产生稳定的激光频谱 ,其激光谱线宽度在 1纳米左右。如果不加光栅 ,非稳定的自由激射的激光器的谱线宽度有 3 0 nm左右。 | 彭川 LE H Q Sarangan A M Ishaug B Thompson L | 2003 | 重庆邮电学院学报(自然科学版)2003，15，3： | 4 |
| 3 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 4 | 9种商业消毒剂对猪2型圆环病毒的杀灭效能测试显示文摘养猪业中常用的许多商业消毒剂,都获得了法国农业部批准。然而对其杀灭增殖初期猪2型圆环病毒(PCV2)的效能却不甚了解。用在法国分离到的PCV2悬液来测试9种商业消毒剂的效能,在20℃下病毒悬液与消毒剂作用30 min后,将该混合液过滤和稀释进行脱毒处理以去除对圆环病毒和猪肾细胞系有害的物质,再经一系列稀释后接种于人工培养的猪肾细胞进行免疫过氧化物酶单层细胞试验(IPMA)测定PCV2的感染性。结果表明,用碘类和苯酚类消毒剂并不能减少病毒滴度。在此着重介绍其他消毒剂效能(病毒滴度减少量≥1.61 log_(10)),其中5种消毒剂:一种含过一硫酸氢钾,另两种含一种季铵盐、一到三种醛、次氯酸钠和氢氧化钠,在标准浓度下或1.5~4倍低于标准浓度时可显著杀灭PCV2;其余两种,其中一种含过一硫酸氢钾,另一种含过氧乙酸和过氧化氢,在标准浓度下或2倍高于标准浓度时也可杀灭PCV2。 | Hélène Martin Marie-Frédérique Le Potier Pierre Maris 杨满军 | 2009 | 今日养猪业2009，，3： | 2 |
| 5 | <ce:link locator='fx1'/> <ce:link locator='fx2'/> Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis显示文摘 | Rami Moucari Tarik Asselah Dominique Cazals–Hatem Hélène Voitot Nathalie Boyer Marie–Pierre Ripault Rodolphe Sobesky Michèle Martinot–Peignoux Sarah Maylin Marie–Hélène Nicolas–Chanoine Valérie Paradis Michel Vidaud Dominique Valla Pierre Bedossa Patrick | 2008 | Gastroenterology2008，，2： | 2 |
| 6 | Acute hemodynamic effects of biventricular DDD pacing in patients with end stage heart failure 显示文摘 | LECLERCG C CAZEAU L LE B H | 1998 | J Am Coil Cardiol1998，32，： | 1 |
| 7 | Cancer risks in patients with chronic lymphocytic thyroiditis 显示文摘 | Holm LE Blomgren H Lwhagen T | 1985 | N Engl J Med1985，312，10： | 1 |
| 8 | 显示文摘 | YU H LE S L ZENG X H | 2014 | Inorg Chem Commun2014，39，： | 1 |
| 9 | Involvement of the serine/threonine p70S6 kinase in TGF-betal-induced ADAM12 expression in cultured human hepatic stellate cells显示文摘 | Le Pabic H L'Helgoualc'h A Coutant A | 2005 | J Hepatol2005，43，6： | 1 |
| 10 | Cloning and expression of five heat shock protein genes in relation to cold hardening and development in the leafminer, Liriomyza sativa 显示文摘 | Huang L H Wang C Z Le K | 2009 | Journal of lnsect Physiology2009，55，： | 1 |
| 11 | Pulmonary dysfunction in rheumatoid arthritis显示文摘 | Frank ST WegJG Hɑrkleroad LE et ɑl | 1973 | Chest1973，63，： | 1 |
| 12 | Molecular variation in the nucleoprotein gene(ORF7) of the porcine reproductive and respiratory syndrome virus (PRRSV)显示文摘 | Le Gall A L Legeay O Bourhy H | 1998 | Virus Research1998，54，1： | 1 |
| 13 | Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome显示文摘 | LE L Q KABAROWSKI J H WENG Z | 2001 | Immunity2001，14，5： | 1 |
| 14 | Infection with Influenza Virus Induces IL-33 in Murine Lungs显示文摘 | Le Goffic Ronan Arshad Muhammad Imran Rauch Michel L’Helgoualc’h Annie Delmas Bernard Piquet-Pellorce Claire Samson Michel | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，6： | 1 |
| 15 | Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice显示文摘 | Le H K Graham L Cha E | 2009 | Int Immunopharmacol2009，9，78： | 1 |
| 16 | Biological control of the rice root-knot nero atode Meloidosyne graminicola on rice, us- ing endophytic and rhizosphere fungi 显示文摘 | Le H T T Padgham J L Sikora R A | 2009 | International Journal of Pest Management2009，55，1： | 1 |
| 17 | Histone lysine demethylase JARIDlaactivates CLOCK-]3MAL1 and influences the circadian clock显示文摘 | Ditacchio L Le H D Vollmers C | 2011 | Science2011，333，： | 1 |
| 18 | Phase I study of the muhidrug resistance inhibitor zosuquidar administered in combination with vi norelbine in patients with advanced solid tumors显示文摘 | Le L H Moore M J Siu L L | 2005 | Cancer Chemother Pharmacol2005，56，2： | 1 |
| 19 | Lung macrophages and dendritic cells express HLA - G molecules in pulmonary diseases 显示文摘 | Pangault C Le Friec G Caulet - Maugendre S Lena H Amiot L Guilloux V Onno M Fauchet R | 2002 | Hum Immunol2002，63，2： | 1 |
| 20 | Control of allergic reactions in mice by an active anti-marine IL-4 immunization显示文摘 | Le Buanec H Paturance S Couillin l | 2007 | Vaccine2007，25，41： | 1 |
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