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| 1 | Injectable hydrogels for cartilage and bone tissue engineering显示文摘Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix(ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed. | Mei Liu Xin Zeng Chao Ma Huan Yi Zeeshan Ali Xianbo Mou Song Li Yan Deng Nongyue He | 2017 | Bone Research2017，5，2： | 54 |
| 2 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 3 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 4 | Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy显示文摘Age-related macular degeneration (AMD) is a complex eye disorder and is the leading cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the central area of retina known as the macula and it is classified as early stage to late stage (advanced AMD). The advanced AMD is classified into the nonexudative or atrophic form (dry AMD) and the exudative or neovascular form (wet AMD). More severe vision loss is typically associated with the wet form. Multiple genetic factors, lipid metabolism, oxidative stress and aging, play a role in the etiology of AMD. Dysregulation in genetic to AMD is established to 46%–71% of disease contribution, with CFH and ARMS2/HTRA1 to be the two most notable risk loci among the 103 identified AMD associated loci so far. Chronic cigarette smoking is the most proven consistently risk living habits for AMD. Deep learning algorithm has been developed based on image recognition to distinguish wet AMD and normal macula with high accuracy. Currently, anti-vascular endothelial growth factor (VEGF) therapy is highly effective at treating wet AMD. Several new generation AMD drugs and iPSC-derived RPE cell therapy are in the clinical trial stage and are promising to improve AMD treatment in the near future. | Yanhui Deng Lifeng Qiao Mingyan Du Chao Qu Ling Wan Jie Li Lulin Huang | 2022 | Genes & Diseases2022，9，1： | 17 |
| 5 | Safety of different acupuncture manipulations for posterior circulation ischemia with vertigo显示文摘Acupuncture at Fengchi(GB20) in the posterior neck improves vertigo.However,subarachnoid hemorrhage and spinal epidural hematoma have been reported to occur after acupuncture in the posterior neck.Therefore,in the present study,we assessed the safety of acupuncture at Fengchi.Laboratory tests and adverse event reports were used to evaluate the safety of different acupuncture manipulations for the treatment of posterior circulation ischemia with vertigo.A total of 136 patients were randomly assigned to four groups.Verum acupuncture was conducted with different needle insertion directions(contralateral paropia or prominentia laryngea) and different needle twisting frequencies(60 or 120 times/minute) at Fengchi and matching acupoints(for example,Zhongwan [CV12],Qihai [CV6],Zusanli [ST36],and Fenglong [ST40]).The patients received 14 treatments over 3–4 weeks.Routine blood analysis,hepatic and renal function tests,urine and feces tests and electrocardiography were performed before the first treatment session and after the final session.Adverse events were recorded after every session.Of the 136 patients,120 completed the study.There were no significant differences between pretreatment and posttreatment test results in any of the groups.Only five patients suffered from minor adverse events(needling pain,slight hematoma and transient chest tightness).No serious adverse events were found.Our results indicate that a 14-session course of needling at Fengchi is relatively safe for treating posterior circulation ischemia with vertigo. | Yan Wen Chao Zhang Xiao-feng Zhao Shi-zhe Deng Si He Ling-hui Huang Guang Tian Zhi-hong Meng | 2016 | Neural Regeneration Research2016，11，8： | 16 |
| 6 | Therapeutic effects of different durations of acupuncture on rats with middle cerebral artery occlusion显示文摘Acupuncture is regarded as an effective therapy for cerebral ischemia. Different acupuncture manipulations and durations may result in different therapeutic effects. In the present study, the Neig uan(PC6) acupoint of rats with occluded middle cerebral arteries was needled at a fixed frequency(3 Hz) with different durations, i.e., 5, 60 and 180 seconds under a twisting-rotating acupuncture method. Results showed that different durations of acupuncture had different therapeutic effects, with 60 seconds yielding a better therapeutic effect than the other two groups. This duration of treatment demonstrated rapid cerebral blood flow, encouraging recovery of neurological function, and small cerebral infarct volume. Experimental findings indicated that under 3 Hz frequency, the treatment of needling Neiguan for 60 seconds is effective for ischemic stroke. | Chao Zhang Yan Wen Xiao-nong Fan Guang Tian Xue-yi Zhou Shi-zhe Deng Zhi-hong Meng | 2015 | Neural Regeneration Research2015，10，1： | 15 |
| 7 | A reliability assessment method based on support vector machines for CNC equipment显示文摘With the applications of high technology,a catastrophic failure of CNC equipment rarely occurs at normal operation conditions.So it is difficult for traditional reliability assessment methods based on time-to-failure distributions to deduce the reliability level.This paper presents a novel reliability assessment methodology to estimate the reliability level of equipment with machining performance degradation data when only a few samples are available.The least squares support vector machines(LS-SVM) are introduced to analyze the performance degradation process on the equipment.A two-stage parameter optimization and searching method is proposed to improve the LS-SVM regression performance and a reliability assessment model based on the LS-SVM is built.A machining performance degradation experiment has been carried out on an OTM650 machine tool to validate the effectiveness of the proposed reliability assessment methodology. | WU Jun DENG Chao SHAO XinYu XIE S Q | 2009 | Science China(Technological Sciences)2009，52，7： | 14 |
| 8 | Study on Quenching and Tempering Process of Q960 High Strength Steel for Construction Machinery显示文摘To develop the Q960 high-strength quenched and tempered steel plates for construction machinery,the effects of quenching and tempering treating regime on the microstructures and mechanical properties were investigated.The results show that the perfect austenization and fine grain size can be achieved by the optimum quenching process that is quenching temperature 900℃ and holding time 20min.Considering performance and production efficiency,the optimum tempering process parameters are found that tempering temperature 600℃ and holding time 40min.The excellent overall properties of specimens with tempered sorbite microstructure can be ultimately obtained.The yield strength is 1030MPa,tensile strength 1080MPa,percentage elongation 16.8% and the Charpy impact energy 144J at-40℃.All these indexes come up to the National Standard GB/T 16270-2009. | WANG Zhao-dong 1,KANG Jian 1,LU Feng 1,2,DENG Xiang-tao 1,WANG Chao 1,WANG Guo-dong 1 (1.State Key Lab of Rolling and Automation,Northeastern University,Shenyang 110004,Liaoning,China 2.Wide Heavy Plate Project Department of Tangshan Iron and Steel Corporation,Tangshan 063000,Hebei,China) | 2011 | Journal of Iron and Steel Research(International)2011，18，S1： | 13 |
| 9 | Review of fully coherent free-electron lasers显示文摘Generation of intense, fully coherent radiation with wide spectral coverage has been a long-standing challenge for laser technologies. Several techniques have been developed in recent years to extend the spectral coverage in optical physics, but none of them hold the potential to produce X-ray laser pulses with very high-peak power. Urgent demands for intense X-ray light sources have prompted the development of free-electron lasers(FELs), which have been proved to be very useful tools in many scientific areas. In this paper, we give an overview of the basic principle of FELs, techniques for realizing fully coherent FELs, and the development of fully coherent FEL facilities in China. | Chao Feng Hai-Xiao Deng | 2018 | Nuclear Science and Techniques2018，29，11： | 12 |
| 10 | Lactobacilli inhibit interleukin-8 production induced by Helicobacter pylori lipopolysaccharide-activated Toll-like receptor 4显示文摘AIM: To investigate the effect of Lactobacillus bulgaricus (LBG) on the Toll-like receptor 4 (TLR4) pathway and interleukin-8 (IL-8) production in SGC-7901 cells treated with Helicobacter pyloriSydney strain 1 lipopolysaccharide (HpyloriSS1-LPS). METHODS: SGC-7901 cells were treated with Hpylori SS1-LPS in the presence or absence of pretreatment for 1 h with viable LBG or supernatant recovered from LBG culture MRS broth (LBG-S). Cellular lysates were prepared for Western blot with anti-TLR4, anti-transforming growth factor β-activated kinase 1 (TAK1), anti-phospho-TAK1, anti-nuclear factor κB (NF-κB), anti-p38 mitogen-activated protein kinase (p38MAPK), and anti-phospho-p38MAPK antibodies. The amount of IL-8 in cell culture medium was measured by ELISA. RESULTS: H pylori SS1-LPS up-regulated the expression of TLR4, stimulated the phosphorylation of TAK1, subsequently enhanced the activation of NF- κB and the phosphorylation of p38MAPK in a time- dependent manner, leading to augmentation of IL-8 production in SGC-7901 cells. Viable LBG or LBG-S pretreatment attenuated the expression of TLR4, inhibited the phosphorylation of TAK1 and p38MAPK, prevented the activation of NF-κB, and consequently blocked IL-8 production.CONCLUSION: H pylori SS1-LPS induces IL-8 production through activating TLR4 signaling in SGC-7901 cells and viable LBG or LBG-S prevents H pyloriSS1-LPS-mediated IL-8 production via inhibition of the TLR4 pathway. | Chao Zhou Feng-Zhen Ma Xue-Jie Deng Hong Yuan Hong-Sheng Ma | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 11 | Multiscale carbon foam confining single iron atoms for efficient electrocatalytic CO2 reduction to CO显示文摘Electrocatalytic CO2 reduction to CO is a sustainable process for energy conversion.However,this process is still hindered by the diffusi limited mass transfer,low electrical conductivity and catalytic activity.Therefore,new strategies for catalyst design should be adopted to solve these problems and improve the electrocatalytic performa nee for CO production.Herein,we report a multiscale carb on foam confining〔single iron atoms prepared with the assistant of S1O2 template.The pore-enriched environment at the macro-scale facilitates the diffusion of reacta nts and products.The graphe ne nano sheets at the nano-scale promote the charge tran sfer duri ng the reaction.The single iron atoms con fined in carb on matrix at the atomic-scale provide the active sites for electrocatalytic CO2 reductio n to CO.The optimized catalyst achieves a CO Faradaic efficiency of 94.9%at a moderate potential of-0.5 V vs.RHE.Furthermore,the performance can be maintained over 60 hours due to the stable single iron atoms coordi nated with four n itroge n atoms in the carb on matrix.This work provides a promising strategy to improve both the activity and stability of single atom catalysts for electrocatalytic CO2 reduction to CO. | Zheng Zhang Chao Ma Yunchuan Tu Rui Si Jie Wei Shuhong Zhang Zhen Wang Jian-Feng Li Ye Wang Dehui Deng | 2019 | Nano Research2019，12，9： | 11 |
| 12 | Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury显示文摘High mobility group box 1(HMGB1)is a ubiquitous nuclear protein that is present in almost all cells and regulates the activity of innate immune responses in both intracellular and extracellular settings.Current evidence suggests that HMGB1 plays a pivotal role in human pathological and pathophysiological processes such as the inflammatory response,immune reactions,cell migration,aging,and cell death.Sepsis is a systemic inflammatory response syndrome(SIRS)that occurs in hosts in response to microbial infections with a proven or suspected infectious etiology and is the leading cause of death in intensive care units worldwide,particularly in the aging population.Dysregulated systemic inflammation is a classic characteristic of sepsis,and suppression of HMGB1 may ameliorate inflammation and improve patient outcomes.Here,we focus on the latest breakthroughs regarding the roles of HMGB1 in sepsis and sepsis-related organ injury,the ways by which HMGB1 are released,and the signaling pathways and therapeutics associated with HMGB1.This review highlights recent advances related to HMGB1:the regulation of HMBG1 might be helpful for both basic research and drug development for the treatment of sepsis and sepsis-related organ injury. | Chao Deng Lin Zhao Zhi Yang Jia-jia Shang Chang-yu Wang Ming-zhi Shen Shuai Jiang Tian Li Wen-cheng Di Ying Chen He Li Ye-dong Cheng Yang Yang | 2022 | Acta Pharmacologica Sinica2022，43，3： | 11 |
| 13 | THEORETICAL AND EXPERIMENTAL STUDIES OF THE FLARING GATE PIER ON THE SURFACE SPILLWAY IN A HIGH-ARCH DAM显示文摘The experimental studies of the flaring gate pier applied on the surface spillway in a high-arch dam show that a shock-wave will appear when the pattern of the flow is kept as super-critical. Meanwhile, the water depth at the outlet increases significantly, the flow moves downward in different directions, and the plunging jet is in a narrow and long shape, with a full longitudinal diffusion. In addition, the variation of the flaring gate pier design parameters affects little the discharge capacity of the surface spillway, these parameters including the contraction ratio , the contraction angle and the spillway chute angle . The pressure on the bottom of the spillway increases along the way and reaches the maximum before the outlet, and then decreases rapidly. Due to the flow impacting, the pressure on both sidewalls increases abruptly at the turning line of the flaring gate pier. To see the characteristics of the flow in the flaring gate pier, a simple calculation method is suggested based on the conversation of energy and mass, and the calculation methods for the jet trajectory and the horizontal length in air are also proposed. The results are found in good agreement with experimental data. | LI Nai-wen LIU Chao DENG Jun ZHANG Xiao-zhe | 2012 | Journal of Hydrodynamics2012，24，4： | 10 |
| 14 | Effect of coating modification of cordierite carrier on catalytic performance of supported NiMnO_3 catalysts for VOCs combustion显示文摘NiMnO_3 perovskite catalysts supported on cordierite modified by Ce_xZr_(1-x)O_2 coatings were prepared using impregnation and sol-gel methods for catalytic combustion of single/double component VOCs at different concentrations and GHSV of 15,000 h^(-1), which were characterized by BET, XRD, SEM, FT-IR, H_2-TPR and O_2-TPD. After coating modification, the specific surface area of catalysts is improved obviously.Among the catalysts, the Ce_(0.75)Zr_(0.25)O_2 coating modified NiMnO_3 catalyst exhibits the best catalytic activity for VOCs combustion with 95.6% conversion at 275 ℃ and has stable activity when catalyst is embalmed at 800 ℃. In addition, the catalyst also presents the excellent water-resistant and conversion stability over time-on-stream condition. The reason is that Ce_(0.75)Zr_(0.25)O_2 coating can promote more lattice distortion and defects and smaller crystal size, which improve oxygen transfer capability and dispersion of active component. | Lei Deng Chao Huang Jiawei Kan Bing Li Yingwen Chen Shemin Zhu Shubao Shen | 2018 | Journal of Rare Earths2018，36，3： | 10 |
| 15 | LAMOST Experiment for Galactic Understanding and Exploration (LEGUE)——The survey's science plan显示文摘We describe the current plans for a spectroscopic survey of millions of stars in the Milky Way galaxy using the Guo Shou Jing Telescope (GSJT, formerly called the Large sky Area Multi-Object fiber Spectroscopic Telescope - LAMOST). The survey will obtain spectra for 2.5 million stars brighter than r < 19 during dark/grey time, and 5 million stars brighter than r < 17 or J < 16 on nights that are moonlit or have low transparency. The survey will begin in the fall of 2012, and will run for at least four years. The telescope's design constrains the optimal declination range for observations to 10 < δ < 50 , and site conditions lead to an emphasis on stars in the direction of the Galactic anticenter. The survey is divided into three parts with different target selection strategies: disk, anticenter, and spheroid. The resulting dataset will be used to study the merger history of the Milky Way, the substructure and evolution of the disks, the nature of the first generation of stars through identification of the lowest metallicity stars, and star formation through study of open clusters and OB associations. Detailed design of the LAMOST Experiment for Galactic Understanding and Exploration (LEGUE) survey will be completed in summer 2012, after a review of the results of the pilot survey. | Li-Cai Deng Heidi Jo Newberg Chao Liu Jeffrey L. Carlin Timothy C. Beers Li Chen Hsu-Tai Lee Carl J. Grillmair Puragra Guhathakurta] Zhan-Wen Han Jin-Liang Hou Sebastien Lepine Jing Li Xiao-Wei Liu Kai-Ke Pan J. A. Sellwood Bo Wang Hong-Chi Wang Fan Yang Brian Yanny Hao-Tong Zhang Yue-Yang Zhang Zheng Zheng Zi Zhu | 2012 | Research in Astronomy and Astrophysics2012，12，7： | 10 |
| 16 | Economic optimization for configuration and sizing of micro integrated energy systems显示文摘Based on analysis of construction and operation of micro integrated energy systems(MIES), this paper presents economic optimization for their configuration and sizing. After presenting typical models for MIES, a residential community MIES is developed by analyzing residential direct energy consumption within a general design procedure. Integrating with available current technologies and local resources, the systematic design considers a prime mover, fed by natural gas, with wind power, photovoltaic generation, and two storage devices serving thermal energy and power to satisfy cooling, heating and electricity demands. Control strategies for MIES also arepresented in this study. Multi-objective formulas are obtained by analyzing annual cost and dumped renewable energy to achieve optimal coordination of energy supply and demand. According to historical load data and the probability distribution of distributed generation output,clustering methods based on K-means and discretization methods are employed to obtain typical scenarios representative of uncertainties. The modified non-dominated sorting genetic algorithm is applied to find the Pareto frontier of the constructed multi-objective formulas. In addition, aiming to explore the Pareto frontier, the dumped energy cost ratio is defined to check the energy balance in different MIES designs and provide decision support for the investors. Finally, simulations and comparision show the appropriateness of the developed model and the applicability of the adopted optimization algorithm. | Haibo YU Chao ZHANG Zuqiang DENG Haifeng BIAN Chenjun SUN Chen JIA | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，2： | 10 |
| 17 | Excision repair cross complementation group 1 polymorphisms and lung cancer risk: a meta-analysis显示文摘背景几研究评估了在在多样的人口,但是与冲突在各个分享相对小的样品的 results.By 的酶和肺癌症风险学习的编码切除修理十字互补组 1 的多型性( ERCC1 )之间的协会,由严密 methods.Methods Embase 执行证据的元分析是可能的,奥维德, Medline 和中国国家知识基础结构被寻找。另外的研究在原来的研究或评论文章从参考书被识别。满足包括标准的文章系统地被考察,并且报导数据用我们从七合格研究与肺癌症和 4332 控制发现了 3810 个案例的 meta-analysis.Results 的统计技术被聚集。T19007C 多型性没在肺癌症风险上显示出重要效果(C 等位基因对 T 等位基因:机会比率(或)=0.91, 95% 信心间隔(CI )=0.80-1.04;CC 对 TT:OR=0.76, 95% CI=0.56-1.02;CC 对(CT+TT ) :OR=0.96, 95% CI=-0.84-1.10 ) 。同样,当成层时,为肺癌症风险上的 T19007C 多型性没有重要主要效果由种族(汉语或白种人) 的分析。没有重要协会在 C8092A 多型性(3060 个病人和 2729 控制) 和肺癌症的风险之间被发现(等位基因对 C 等位基因:OR=1.03, 95% CI=0.95-1.11;AA 对 CC:OR=1.08, 95% CI=-0.88-1.33;AA 对(AC+CC ) :OR=1.08, 95% CI=-0.88-1.31 ) 我们几乎没在白种人或汉中国人民发现在 ERCC 1 的 T1900C 或 C8092A 多型性和肺癌症的风险之间的一个协会的小证据的 .Conclusion。 | CAO Chao ZHANG Yan-mei WANG Ran SUN Shi-fang CHEN Zhong-bo MA Hong-ying YU Yi-ming DING Qun-li SHU Li-hua DENG Zai-chun | 2011 | Chinese Medical Journal2011，，14： | 9 |
| 18 | Serum uric acid as an index of impaired renal function in congestive heart failure显示文摘BackgroundHyperuricemia 经常是在有心失败的病人的现在。许多病理学的条件例如织物局部缺血,肾的功能缺陷,心脏的功能缺陷,新陈代谢的症候群,和煽动性的地位,可以影响尿酸(UA ) 新陈代谢。这研究是回顾地在心 failure.MethodsWe 估计他们的潜在的关系到 UA 新陈代谢估计的临床的特征, echocardiological ,肾,与充血的心失败在随机选择的成年人的一个大队在心血管的疾病和 UA 新陈代谢根据他们的参与的以前的证据选择的新陈代谢、煽动性的变量( n = 553 )。由索引聚类,那些变量用因素 analysis.ResultsIn 因素分析被探索,尿酸(SUA ) 形成了的浆液包括了浆液 creatinine (SCr ) 和血脲氮(甜面包) 的肾的功能的变量的主要的簇的部分。在有充血的心失败的病人的变量之间的 Univariate 关联系数证明为 SUA 的最强壮的关联与甜面包(r = 0.48, P <0.001 ) 并且 SCr (r = 0.47, P <0.001 ).ConclusionsThere 是在 SUA 层次和在有充血的心失败的病人的肾的功能的措施之间的一种反的关系。在 SUA 和 SCr 和甜面包层次之间的强壮的关联建议提高的 SUA 集中在心失败反映肾的功能的一个缺陷。 | Yu Tian Ying Chen Bao Deng Gang Liu Zhen-Guo Ji Qing-Zhen Zhao Yu-Zhi Zhen Yan-Qiu Gao Li Tian Le Wang Li-Shuang Ji Guo-Ping Ma Kun-Shen Liu Chao Liu | 2012 | Journal of Geriatric Cardiology2012，9，2： | 9 |
| 19 | Lumbopelvic Fixation and Sacral Decompression for U-shaped Sacral Fractures: Surgical Management and Early Outcome显示文摘 | Yuan-long XIE Lin CAI An-song PING Jun LEI Zhou-ming DENG Chao HU Xiao-bing ZHU | 2018 | Current Medical Science2018，38，4： | 9 |
| 20 | Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders显示文摘Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequencing data available to previous studies.Here,w e build a list of putative adaptive variants,including 63 missense,7 loss-of-function;1,298 evolutionarily conserved variants and 509 expression quantitative traits loci.Notably,the top signal of selection is located in TMEM 247,a transmembrane protein-coding gene.The Tibetan version of TMEM 247 harbors one high-frequency(76.3%)missense variant,rsl 16983452(c.248C>T;p.Ala83Val);with the T allele derived from archaic ancestry and carried by>94%of Tibetans but absent or in low frequencies(<3%)in non-Tibetan populations.The rsl 16983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p=5.78×10^-5),red blood cell count(p=5.72×10^-7)and hematocrit(p=2.57×10^-6).In particular,TMEM247-rs 116983452 shows greater effect size and better predicts the phenotypic outcome than any E P A S1 variants in association with adaptive traits in Tibetans.Modeling the interaction between TM£M247-rsl 16983452 and EPAS1 variants indicates weak but statistically significant epistatic effects.Our results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism. | Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu | 2019 | National Science Review2019，6，6： | 9 |
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