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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | 中阿40m射电望远镜选址与电磁环境监测显示文摘优良站址的选择是射电望远镜完成既定科学目标并实现高效运行的重要保障。影响射电望远镜选址的主要因素包括电磁环境、水文、气象、地质条件、隔离性与可及性等。对于射电天文观测而言,来自宇宙天体的射电信号往往极其微弱,对望远镜系统及设备的灵敏度要求极高。然而,随着人类活动的不断加强,人们日常工作和生活中使用的电子通讯设备越来越多,无线电干扰源呈爆炸式涌现。在射电望远镜选址工作中,进行电磁环境监测,选择一个电磁环境良好的站址,对于射电望远镜实现常规观测运行、获取有效数据资料至关重要。同时,电磁环境监测结果也是射电望远镜接收机系统研制、站址电磁环境及无线电宁静区立法保护的重要依据。中阿天文学者和技术人员历时1年半完成了16个候选站址的初步勘察,并对优选出的3个主要候选站址进行了深入细致的电磁环境监测工作,获得了大量可靠数据。中阿双方依据电磁环境监测结果并结合各主要候选站址的水文、气象、地质及道路等条件,最终将位于Talacasto戈壁的3号候选站址确定为中阿CART射电望远镜的建设站点。 | 赵卫普 李建斌 李金增 孙建民 齐力 罗滔 马晓耘 莫铠玮 李鹏程 夏跃兵 MALLAMACI C C PODESTA R C PACHECO A M ACTIS E CASTRO J I ALVIS R H LOPEZ C E FRANCILE C PODESTA F PEREZ J | 2014 | 天文学进展2014，32，3： | 4 |
| 3 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 4 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 5 | Optimisation of shape and process parameters in metal forging using genetic algorithms显示文摘 | CASTRO C F ANTONIO C A C SOUSA L C | 2004 | Journal of Material Processing Technology2004，146，3： | 1 |
| 6 | Effect of a highly concentrated lipopeptide extract of Bacillus subtilis on fungal and bacterial cells 显示文摘 | Etchegaray A de Castro Bueno C de Melo I S | 2008 | Archives of Microbiology2008，190，2： | 1 |
| 7 | Singular and non-singular approaches for predicting fatigue crack growth be- havior显示文摘 | Castro J T P Meggiolaro M A Miranda A C O | 2005 | International Journal of Fatigue2005，27，： | 1 |
| 8 | Mechanical properties of polyester mooring cables 显示文摘 | FERNANDES A C DEL VECCI-IIO C J M CASTRO G A V | 1999 | International Journal of Offshoreand Polar Engineering1999，9，3： | 1 |
| 9 | Structural, morphological and surface properties as a function of composition of Ru + Ti + Pt mixed-oxided electrodes 显示文摘 | LASSALI T A F CASTRO S C D BOODTS J F C | 1998 | Electrochimica Acta1998，43，1617： | 1 |
| 10 | Critical point theory and the number of solutions of a nonlinear dirichlet problem显示文摘 | Castro A Lazer A C | 1979 | Annali di Matematica Pura ed Applicata1979，120，1： | 1 |
| 11 | Pathogenic variation a- mong isolates of Pyrlcularia grisea infecting rice,wheat and grasses in Brazil显示文摘 | Prabhu A S Filippi M C Castro N | 1992 | Trop Pest Manage1992，38，： | 1 |
| 12 | Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors 显示文摘 | Castro A Jerez MJ Gil C | 2005 | Med Res Rev2005，25，2： | 1 |
| 13 | PROSITE,aprotein domain database for functional characterization and anno-tation显示文摘 | S IGRIST C J A CERUTTI L de CASTRO E | 2010 | Nucleic Acids Research2010，38，1： | 1 |
| 14 | Selec- tive precipitation/UV production of magnetite particles obtained from the iron recovered from acid mine drain- age 显示文摘 | Silva R A Castro C D Viganico E M | 2012 | MinerEng2012，，： | 1 |
| 15 | Statistical modelling of the LMS channel显示文摘 | Fontan F Castro M A Cabado C and Garcia J | 2001 | IEEE Transactions on Vehicular Technology2001，50，6： | 1 |
| 16 | Parametric studies on automotive radiators 显示文摘 | OLIET C OLIVA A CASTRO J | 2007 | Applied Thermal Engineer- ing2007，27，12： | 1 |
| 17 | First record of Meloidogyne enterolobii on guava in the state of Alagoas,Brazil显示文摘 | Castro J M C Santana T A S | 2010 | Nematologia Brasileira2010，34，3： | 1 |
| 18 | Phenolic composition of South American red wines classified according to their antioxidant activity, retail price and sensory quality显示文摘 | Granato D Katayama F C U Castro I A | 2011 | Food Chemistry2011，，129： | 1 |
| 19 | Development of mullite/zirconia composites from a mixture of aluminum dross and zircon 显示文摘 | Castro M N I Robles J M A Hernndez D A C | 2009 | Ceramics International2009，35，2： | 1 |
| 20 | New dimerie surfactants from alkyl glucosides显示文摘 | J L Castro Mariano J Kovensky C A Fernandez | 1999 | Tetrahedron1999，55，12： | 1 |
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