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| 1 | Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis. | Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete | 2012 | World Journal of Gastroenterology2012，18，11： | 6 |
| 2 | Office hysteroscopy and compliance:mini-hysteroscopy versus traditional hysteroscopy in a randomized trial显示文摘 | Carlo D Giuseppina S Maria E | 2003 | Hum Reprod2003，18，： | 1 |
| 3 | Capillaroscopy in psoriatic and rheumatoid arthritis: a useful tool for differential diagnosis 显示文摘 | Graceffa D Amorosi B Maiani E Bonifati C Cbi menti MS Perrieone R Di Carlo A | 2013 | Arthritis2013，，95： | 1 |
| 4 | Environmental Effects of Aquifer Overexploitation: A Case Study in the Highlands of Mexico 显示文摘 | Maria V E Carlos D D | 2002 | Enviromnental Management2002，29，2： | 1 |
| 5 | Sorption of rare earth elements from seawater onto synthetic mineral particles: An experimental approach 显示文摘 | Koeppenkastrop D De Carlo E H | 1992 | Chemical Geology1992，95，： | 1 |
| 6 | 16S rRNA gene sequence analysis of Photobacterium damselae and nested PCR method for rapid detection of the causative agent of fish pasteruellosis显示文摘 | CARLOS R O MATTHEW D C ALICIA E T | 1999 | Appl Environ Microbiol1999，65，7： | 1 |
| 7 | Rapid detection of the F508 detection in Cystic Fibrosis by allele specific PCR and electrochemiluminescent detection 显示文摘 | STERN H J CARLOS R D SCHUTZBANK T E | 1995 | Clinical Biochemistry1995，28，： | 1 |
| 8 | 3-(2-Carboxyethyl ) -4,6-dichloro-1H-indole-2-carboxylic acid : An allosteric inhibitor of fructose-1, 6-bisphosphatase at the AMP site 显示文摘 | WRIGHTS W CARLO A A DANLEY D E | 2003 | Bioorg Med Chem Lett2003，13，12： | 1 |
| 9 | Criteria for robust stability and stabilization of uncertain linear systems with state-delay显示文摘 | Carlos E Souza D | 1997 | Automatica1997，33，9： | 1 |
| 10 | IPv6 security ehallenges显示文摘 | Carlos E Caicedo James B D Joshi Summit R Tu- ladhar | 2009 | Computer2009，42，2： | 1 |
| 11 | Differential alteration in intestinal epithelial cells expression of toll-like-receptors 3(TLR3) and TLR4 in inflammatory bowel disease显示文摘 | Carlo E Podolsky D K | 2000 | Infect Immunols2000，68，12： | 1 |
| 12 | Seasonal variability of the colored dissolved organic matter during the 1994-95 NE and SW Monsoons in the Arabian Sea显示文摘 | Carlos E Castillo D Coble P G | 2000 | Deep-Sea Research Ⅱ2000，47，： | 1 |
| 13 | Spectral elec- tromyography assessment of back muscles in patients with low back pain undergoing rehabilitation 显示文摘 | Serge H R Carlo J D Mark E B S | 1995 | Spine1995，20，1： | 1 |
| 14 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 15 | Criteria for robust stability and stabilization of uncertain linear systems with state-delay显示文摘 | Li X Carlos E Souza D | 1997 | Automatica1997，33，9： | 1 |
| 16 | Differential alteration in intestinalepithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in in-flammatory bowel disease 显示文摘 | CARLO E PODOLSKY D K | 2000 | Infect Immun2000，68，12： | 1 |
| 17 | Differential alteration in intestinal epithelial cell expression of toll - like receptor 3 ( TLR3 ) and TLR4 in inflammatory bowel disease显示文摘 | Carlo E Podolsky D K | 2000 | Infect Immun2000，68，： | 1 |
| 18 | Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomasof the liver显示文摘 | Maione D Di Carlo E Li W | 1998 | EMBO J1998，17，19： | 1 |
| 19 | Physiology of effects of temporary immersion bioreactors on micropropagated pineapple plantlets 显示文摘 | MARITZA E GUY S CARLOS Y D | 2003 | In Vitro Cell Dev Biol : Plant2003，39，： | 1 |
| 20 | Honeycomb supported Co3O4/CeO2 catalyst for CO/CH4 emissions abatement: Effect of low Pd Pt content on the catalytic activity 显示文摘 | LIOYYA L F CARLO G D PANTALEO G DDGANELLO G MERLONE B E PIDRIA M | 2007 | Catal Commun2007，8，： | 1 |
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