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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 3 | Preferential interaction of Salmonella typhimurium with mouse Peyer's patch M cells显示文摘 | CLARK M A JEPSON M A SIMMONS N L | 1994 | Res Microbiol1994，145，7： | 1 |
| 4 | Octopus beak identification-resolution at a regional level (Cephalopoda, Octopoda: Southern Africa) 显示文摘 | Smale M J Clarke M R Klages N T | 1993 | S Afr J Mar Sci1993，13，1： | 1 |
| 5 | Effects of a comprehensive school based asthma program on symptoms, parentmanagement, grades, and absenteeism显示文摘 | Clark N M Brown R Joseph C L | 2004 | Chest2004，29，125： | 1 |
| 6 | Diabetes in older adults: a consensus report 显示文摘 | Sue Kirkman M Bfiscoe VJ Clark N | 2012 | J Am Geriatr Soc2012，60，12： | 1 |
| 7 | Ultrasound imaging and second- ary screening for congenital dislocation of the hip 显示文摘 | Boeree N R Clarke N M | 1994 | J Bone Joint Surg Br1994，76，4： | 1 |
| 8 | The SpatioTemporal Form of Urban Growth: Measurement, Analysis and Modeling显示文摘 | Herold M Goldstein N C Clarke K C | 2003 | Remote Sensing of Environment2003，86，： | 1 |
| 9 | Validation of Ocean Tide Models Around Antarctica Using On- shore GNSS and Gravity Data显示文摘 | King M A Penna N T Clarke P J | 2005 | J Geophys Res- Sol Earth2005，110，08401： | 1 |
| 10 | Prognostic relevance of micro-vessel density in cancer of the urinary bladder显示文摘 | Chaudharry R Bromley M Clarke N | 1999 | Anticancer Rec1999，19，4： | 1 |
| 11 | 3D finite element analyses of insertion of the nucleus standard straight and the contour elec- trode arrays into the human cochlea 显示文摘 | Kha H N Chen B K Clark G M | 2007 | J Biomechan2007，40，12： | 1 |
| 12 | Structure-function studies of the human immunodeficiency virus type 1 matrix protein, pl7显示文摘 | Cannon P M Matthews S Clark N | 1997 | J Virol1997，71，5： | 1 |
| 13 | Enhanced cleavage rates following in vitro maturation of pig oocytes within polydimethylsiloxane-borosilicate microchannels 显示文摘 | Hester P N Roseman H M Clark S G | 2002 | Theriogenology2002，57，： | 1 |
| 14 | Factors regulationg the rat inslin-like growth factor-binding protem-1 respons to octreotide显示文摘 | Lewitt M S Cameron-Smith D Clarke N M | 1998 | J Endocrinol1998，158，1： | 1 |
| 15 | School-based primary prevention of depressive symptomatology in adolescents: findings from two studies显示文摘 | Clarke G N Hawkins W Murphy M | 1993 | J Adolesc Res1993，8，2： | 1 |
| 16 | Paper-based, printed zinc-air battery显示文摘 | Hilder M Winther-Jensen B Clark N B | 2009 | J Power Sources2009，194，： | 1 |
| 17 | Characteristics of the microplate method of enzyme - linked immunosorbent assay for the detection of plant viruses显示文摘 | Clark M F Adams A N | 1977 | Journal of Genernal Virology1977，34，： | 1 |
| 18 | Imaging characteristics and growth of subependymal g(ant astrocytomas显示文摘 | Clark M J Foy AB Wetjen N | 2006 | Neurosurg Fo- cus2006，20，1： | 1 |
| 19 | Diabetes in older adults:a consensus report显示文摘 | Sue Kirkman M Briscoe VJ Clark N | | 0，，12： | 1 |
| 20 | Quality characteristics of durum wheat lines deriving high protein from a Triticum dicoccoides (6B) substitution 显示文摘 | Kovacs M L P Howes N K Clarke J M | 1998 | Journal of Cereal Science1998，27，： | 1 |
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