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1562篇 您的检索式：作者名="CLARK D A"

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	题名	作者	年代	出处	被引量
1	Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘	Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A.	2009	中国神经肿瘤杂志2009，7，4：	3
2	The gene for an abundant parasite coat protein predicts tandemly repetitive mental binding domains 显示文摘	Clark T G Lin Tian-Long Jackwood D A	1999	Gene1999，229，：	2
3	Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation显示文摘AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral consistently achieving purity. Rat heterotopic cardiac transplantation and mixed lymphocyte reactivity were done using genetically inbred strains of PVG(donor) and DA(recipient). For the mixed lymphocyte reaction stimulator cells were irradiated with 3000 rads using a linear accelerator. Cyclosporin A was administered by gavage and venous blood collected 2 h later(C_2). The blood levels of Cs A(Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay(EMIT) on Cobas Mira. Statistical analyses of interactions were done by an acceleratedfailure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte reactivity.RESULTS: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and Cs A in the prolongation of cardiac allograft survival for dose ranges of Cs A by castanospermine of(0 to 2) mg/kg by(0 to 200) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) and(0 to 3) mg/kg by(0 to 100) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) respectively. The addition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of Cs A. On the contrary, cessation of castanospermine in the presence of Cs A at 2 mg/kg significantly increased the Cs A level(P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. CONCLUSION: There is synergistic interaction between castanospermine and Cs A in rat cardiac transplantation. Neither the mixed lymphocyte reaction nor the metabolism of Cs A provides an explanation.	Adrian D Hibberd David A Clark Paul R Trevillian Patrick Mcelduff	2016	World Journal of Transplantation2016，6，1：	2
4	Antifungal evaluation of pseudolaric acid B, a major constituent of pseudolarix kaempferi显示文摘	Li E Clark A M Hufford C D	1995	J Nat Prod1995，58，：	1
5	Ceil contact as an independent factor moduletating cardiac myocytes hypertrophy and survival in long-term primary culture显示文摘	Clark W A Decker M L Janes D M	1998	J Mol Cell Cardiol1998，30，：	1
6	Using a cellular automaton model to forecast the effects of urban growth on habitat pattern in southern California显示文摘	Syphard A D Clarke K C Franklin J	2005	Ecological Complexity2005，2，2：	1
7	The tobacco salicylic acid-binding protein 3(SABP3)is the chloroplast carbonic anhydrase,which exhibits antioxidant activity and plays a role in the hypersensitive defense response显示文摘	Slaymaker D H Navarre D A Clark D	2002	Proc Natl Acad Sci USA2002，99，11：	1
8	Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘	Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J	2004	Proc Natl Acad Sci USA2004，101，26：	1
9	Use of a peptide rather than free amino acid nitrogen source in chemically defined 'elemental' diets显示文摘	SILK D B A FAIRCLOUGH P D CLARK M L	1980	Journal of Parenteral and Enteral Nutrition1980，4，：	1
10	Measuring thermal and mechanical stresses on optical fiber in a DC module using fiber Bragg gratings显示文摘	Glaesemann G S Smith J A Clark D A	2005	Journal of Lightwave Technology2005，23，11：	1
11	Micrometastases in esophagogastric cancer:high detection rate in resected rib segments显示文摘	O'SULLIVAN G C SHEEHAN D CLARKE A	1999	Gastroenterology1999，116，3：	1
12	Congestion Control With Explicit Rate Indication显示文摘	Charny A Clark D Jain R	1995	IEEE1995，，：	1
13	A method for the determination of nitrification rates in oligotrophicmarine seawater by gas chromatography/mass spectrometry显示文摘	CLARK D R REES A P JOINT I	2007	Mar Chem2007，103，：	1
14	An assessment of the utility of a non-metric digital camera for measuring standing trees显示文摘	CLARK N A WYNNE R H SCHMOLDT D L	2008	Computers and Electronics in Agriculture2008，28，：	1
15	Fault injection: A method for validating computer-system dependability显示文摘	Clark J A Pradhan D K	1995	Computer1995，28，6：	1
16	Hot water separation of bitumen fromAlberta bituminous sand显示文摘	Clark K A Pasternack D S	1932	Industrial and Engineering Chemistry1932，24，：	1
17	Determination of width of meander-belt sandstone reservoirs from vertical downhole data,Mesaverde Group,Piceance Greek Basin,Colorado显示文摘	LORENZ J C HEINZE D M CLARK J A	1985	AAPG Bulletin1985，69，5：	1
18	Particle nu- cleation in the tropical boundary layer and its cou- pling to marine sulfur sources 显示文摘	Clarke A Davis D Kapustin V e a/	1998	Science1998，282，5386：	1
19	High frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term 显示文摘	HENDERSON-SMART D J DE PAOLI A G CLARK R H	2009	Cochrane Database Syst Rev2009，3，00：	1
20	Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation显示文摘	SAMANT RS CLARK DW FILLMORE RA	2007	Mol Cancer2007，6，：	1

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