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| 1 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 2 | Numerical investigation of the influence of rock shape on rockfall trajectory显示文摘 | Glover J Schweizer A Christen M Gerber W Leine R Bartelt P | 2012 | Geophysical Research Abstracts2012，14，11： | 1 |
| 3 | Hemodynamic effects of intermittent pneumatic compression of the lower limbs during laparo- scopic cholecystectomy 显示文摘 | Christen Y Reymond MA Vogel J J | 1995 | Am J Surg1995，170，： | 1 |
| 4 | Eukaryotic richness in the abyss: insights from pyrotag sequencing 显示文摘 | Pawlowski J Christen R Lecroq B | 2011 | PLoS One2011，6，18： | 1 |
| 5 | Deposition of biaxially-oriented metal and oxide buffer-layer films on textured Ni tapes:new substrates for high-current,high-temperature superconductors显示文摘 | He Q Christen D K Budai J D | 1997 | Physica C1997，275，： | 1 |
| 6 | Production of taxalor txaol likecompounds in all calture 显示文摘 | Christen A A Gibson D M Bland J | 1991 | US Patent1991，50，： | 1 |
| 7 | Protective effect of anethol dithiolthione against acetaminophen hepatotoxicity in mice显示文摘 | Warnet J M Christen M O Thevenin M | 1989 | Pharmacol Toxicol1989，65，： | 1 |
| 8 | Controlled drainage for improved water management in arid regions irrigated agriculture显示文摘 | AYARS J E CHRISTEN E W | 2006 | Agricultural Water Management2006，86，12： | 1 |
| 9 | Effect of climate change on greenhouse gas emissions from arable crop rotations显示文摘 | J?rgen E. Olesen Gitte H. Rub?k Tove Heidmann S?ren Hansen Christen D. B?rgensen | 2004 | Nutrient Cycling in Agroecosystems2004，，2： | 1 |
| 10 | Tension controlled ligament balanced total knee arthroplasty:5-year results of a soft tissue orientated surgical technique显示文摘 | Wyss T Schuster A J Christen B | 2008 | Arch Orthop Trauma Surg2008，128，2： | 1 |
| 11 | Li- popolysaccharide is in close proximity to each of the proteins in its membrane recept or complex transfer from CD14 to TLR4 and MD - 2显示文摘 | DA SILVA CORREIA J SOLDAU K CHRISTEN U | 2001 | J Biol Chem2001，276，21： | 1 |
| 12 | Assessment of effluent contaminants from three facilities discharging marcellus shale wastewater to surface waters in pennsylvania显示文摘 | Ferrar K J Michanowicz D R Christen C L | 2013 | Environmental Science & Technology2013，47，7： | 1 |
| 13 | Second - trimester ma- ternal serum alpha - fetoprotein and the risk of adverse pregnancy out- come 显示文摘 | Krause TG Christens P Wohlfahrt J | 2001 | Obstetric and Gynecology2001，97，2： | 1 |
| 14 | Characterization and early detection of grapevine ( Vitis vinifera) stress responses to esca disease by in situ chlorophyll fluorescence and comparison with drought stress显示文摘 | CHRISTEN D SCHONMANN S JERMINI M STRASSER R J DEFAGO G | 2007 | Environmental and Experimental Botany2007，60，： | 1 |
| 15 | Deposition of biaxial oriented metal and oxide buffer-layer films on textured Ni tapes:New substrates for high-current,high-temperature superconductors显示文摘 | He Qing Christen D K Budai J D | 1997 | Physical1997，275，12： | 1 |
| 16 | Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex显示文摘 | Da Silva Correia J Soldau K Christen U | | 0，，24： | 1 |
| 17 | Optical micro-charac- terization of group-Hl-nitrides: Correlation of structural, electronic and optical properties显示文摘 | Christen J Riemann T Bertram F | 2003 | Phys Status Solidi C2003，0，6： | 1 |
| 18 | Controlled drainage for improved water management in arid regions irrigatedagricuhure 显示文摘 | Ayars J E Christen E W Hornbuckle J W | 2006 | Agricultural Water Management2006，86，12： | 1 |
| 19 | Maternal age and fetal loss: population based registerlinkage study显示文摘 | Nybo Andersen AM Wohlfahrt J Christens P | 2000 | BMJ2000，320，7251： | 1 |
| 20 | Laser-interference lithography tailored for highly symmetrically arranged Zn0 nanowire arrays显示文摘 | Kim D S Ji R Fan H J Bertram F Scholz R Dadgar A Nielsch K Krost A Christen J.Gosele U Zacharias M | | 0，，01： | 1 |
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