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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 3 | Digital inkjet printing for chitosan-treated cotton fabric显示文摘 | P S R Choi C W M Yuen S K A Ku | 2005 | Fibers and Polymers2005，6，3： | 1 |
| 4 | Purification and characteriza-tion of iron superoxide dismutase and copper-zine superoxide dismutase from Acanthamoeba castellanii显示文摘 | Choi D H N a B K Seo M S | 2000 | J Parasitol2000，86，5： | 1 |
| 5 | Thermally driven thin film bulk acoustic resonator voltage controlled oscillators integrated with microheater elements 显示文摘 | Lee H M Kim H T Choi H K | 2004 | Jpn J Appl Phys Part2-Lett2004，43，1： | 1 |
| 6 | Ribozyme-mediated cleavage of the human survivin mRNA and inhibition of antiapoptotic function of survivin in MGF-7 cells 显示文摘 | Choi K S Lee T H Jung M H | 2003 | Cancer Gene Ther2003，10，2： | 1 |
| 7 | Catalytic properties of early transition metal nitrides and carbides:n-butane hydrogenolysis,dehydrogenation and isomerization显示文摘 | NEYLON M K CHOI S KWON H CURRY K E THOMPSON L T | 1999 | Appl Catal A1999，183，2： | 1 |
| 8 | The novel acute phase protein, IHRP, inhibits actin polymerization and phagocytosis of polymorphonuclear cells显示文摘 | Choi - Miura N H Takahashi K Yoda M | 2000 | Inflamm Res2000，49，： | 1 |
| 9 | A novel startup scheme of stator-flux-oriented vector-controlled induction motor drive without torque jerk显示文摘 | Chun T W Choi M K Bose B K | 2003 | IEEE Transactions on Industry Applications2003，39，3： | 1 |
| 10 | Photocurrent enhancement of n-type Cu2 O electrodes achieved by controlling dendritic bran-ching growth显示文摘 | MCSHANE C M CHOI K S | 2009 | Journal of the American Chemical Society2009，131，7： | 1 |
| 11 | Effects of myosin heavy chain isoforms on meat quality, fatty acid composition, and sensory evaluation in Berkshire pigs显示文摘 | Kang Y K Choi Y M Lee S H | 2011 | Meat Sci2011，89，4： | 1 |
| 12 | Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos显示文摘 | Kang Y K Park J S Koo D B Choi Y H Kim S U Lee K K Han Y M | 2002 | The EMBO journal2002，21，5： | 1 |
| 13 | Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications显示文摘 | Ryter S W Alam J Choi A M K | 2006 | Physiological Reviews2006，86，： | 1 |
| 14 | Dehydro -ct -lapachone isolated from Catalpa ovata stems: activity against plant pathogenic fungi 显示文摘 | JUN YOUNG CHO HAE YOUNG K/M GYUNG JA CHOI | 2006 | Pest Management Science2006，62，： | 1 |
| 15 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 16 | High catalytic activity of Pd2+-exchanged mesoporous sodalite and NaA zeolite for bulky aryls coupling:reusability under aerobic condition显示文摘 | Choi M Lee D H Na K Yu B W Ryoo R | | 0，，20： | 1 |
| 17 | The synthesis of a zeolite via pseudomorphic crystallization 显示文摘 | CHOI M NA K RYO0 hierarchically porous BEA R | 2009 | Chemical Communications2009，，20： | 1 |
| 18 | Robotic anterior RAMPS in well selected lefvsided pancreatic cancer显示文摘 | Choi S H Kang C M Hwang H K | 2012 | J Gastrointest Surg2012，16，4： | 1 |
| 19 | LC-MS/MS signal suppression effects in the anaysis of pesticides in complex environmental matrices显示文摘 | Choi B K Hercules D M Gusev A I | 2001 | Fresenius'' Journal of Analytical Chemistry2001，369，34： | 1 |
| 20 | Highly stable Pt monolayer on PdAu nanoparticle electrocatalysts for the oxygen reduction reaction显示文摘 | SASAKI K NAOHARA H CHOI Y M | 2012 | Nature Communications2012，3，： | 1 |
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