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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 3 | Bone induction by BMP-2 transduced stem cells derived from human fat显示文摘 | Dragoo J L Choi J Y Lieberman J R Huang J, Zuk P A, Zhang J, Hedrick M H, Benhaim P | | 0，，： | 2 |
| 4 | Activated leukocyte cell adhesion molecule (ALCAM) and annexin II are involved in the metastatic progression of tumor cells after chemotherapy with Adriamycin显示文摘 | Choi S Kobayashi M Wang J | 2000 | Clin Exp Metastasis2000，18，1： | 2 |
| 5 | Serotonin receptor 2A gene polymorphism ( - 1438A/G) and short - term treatment response to citalopram 显示文摘 | Choi M J Kang RH Ham B J | 2005 | Neuropsychobiology2005，52，3： | 1 |
| 6 | Outcome of adult severe or very severe aplasfic anemia treated with immunosuppressive therapy compared with bone marrow transplantation: multicenter trial 显示文摘 | Ahn M J Choi J H Lee Y Y | 2003 | Int J Hematol2003，78，2： | 1 |
| 7 | Growth characteristics of carbon nanotubes via aluminum nanopore template on Si substrate using PECVD显示文摘 | Kim M J Choi J H Park J B | 2003 | ThinSolid Films2003，435，： | 1 |
| 8 | Bilayered scaffold for engineering eellutarized blood vessels显示文摘 | J u Y M Choi J S Atala A | 2010 | Biomaterials2010，31，15： | 1 |
| 9 | Relationship be- tween psychological factors and quality of life in subtypes of gastroesophageal reflux disease显示文摘 | Oh J H Kim T S Choi M G | 2009 | Gut Liver2009，3，4： | 1 |
| 10 | Optical coding of mammalian cells using semiconductor quantum dots 显示文摘 | Mattheakis L C Dias J M Choi Y J | 2004 | Anal Biochem2004，322，2： | 1 |
| 11 | The effect of coupling agent on electrical and mechanical properties of carbon fiber/phenolic resin composites 显示文摘 | Choi M H J eon B H Chung I J | 2000 | Polymer2000，41，9： | 1 |
| 12 | 显示文摘 | Choi M H Jeon B H Chung I J | 2000 | Polymer2000，41，： | 1 |
| 13 | Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes显示文摘 | Sommerfeldt N Beckhove P Ge Y Sehutz F Choi C Bucur M Domsehke C Sohn C Sehneeweis A Rom J Poll- mann D Leneht D Vlodavsky I Sehirrmaeher V | 2006 | Cancer Res2006，66，15： | 1 |
| 14 | Development of single reagent for fluorescence polarization immunoassay of Atrazlne 显示文摘 | Choi M J Lee J R Eremln S A | 2002 | Food and Agricultural Immunology2002，14，： | 1 |
| 15 | Critical evaluation of bcl-6 protein expression in diffuse large B-cell lymphoma of the stomach and small intestine显示文摘 | Kwon M S Go J H Choi J S | 2003 | Am J Surg Pathol2003，27，： | 1 |
| 16 | Continuous- conduction-mode SEPIC converter with low reverse- recovery loss for power factor correction 显示文摘 | KWON J M CHOI W Y LEE J J | 2006 | Electric Power Applications2006，153，5： | 1 |
| 17 | Antidiabetic actions of a non-agonist PPARγligand blocking CdkS-mediated phosphorylation 显示文摘 | Choi J H Banks A S Kamenecka T M | 2011 | Nature2011，477，7365： | 1 |
| 18 | Intracrystalline structure of DNA molecules stabilized in the layered double hydroxide显示文摘 | Oh J M Kwak S Y Choy J H | 2006 | Journal of Physics and Chemical of Solids2006，67，56： | 1 |
| 19 | Solid pseudopapillary tumor of the pancreas: typical and atypical manifestations显示文摘 | Choi J Y Kim M J Kim J H | 2006 | AJR2006，187，2： | 1 |
| 20 | Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos显示文摘 | Kang Y K Park J S Koo D B Choi Y H Kim S U Lee K K Han Y M | 2002 | The EMBO journal2002，21，5： | 1 |
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