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1712篇 您的检索式:作者名="CHEN YJ"
    题名 作者 年代 出处 被引量
1Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer(摘要)显示文摘Hu, ZB Chen, X Zhao, Y Tian, T Jin, GF Shu, YQ Chen, YJ Xu, L Zen, K Zhang, CY Shen, HB 2010南京医科大学学报(自然科学版)2010,30,7:141
2Recent developments and future prospects of Vitreoscilla hemoglobin application in metabolic engineering显示文摘Zhang, L Li, YJ Wang, ZN Xia, Y Chen, WS Tang, KX 2007中国生物学文摘2007,21,10:25
3前瞻随机对照比较射频消融联合/不联合经导管肝动脉栓塞化疗术治疗肝细胞癌的临床研究显示文摘背景和目的射频消融术(RFA)是近年发展比较快的肝癌治疗手段,具有微创、操作简单、可反复治疗的特点,多项研究证明其对于小肝癌的疗效与手术切除相似,被认为是不能手术小肝癌的主要替代手段,甚至可作为小肝癌的一线治疗手段。经导管肝动脉栓塞化疗术(TACE)是中晚期肝癌的主要治疗手段。TACE联合射频消融,TACE可发现和治疗一些以前没有发现的微小病灶,控制肝肿瘤周围可能存在的微卫星灶,并有利于日后射频治疗的施行;此外,射频消融术前行TACE治疗,可以减少肝肿瘤的血流,从而减少射频消融过程中的热流失,从而增加消融范围;射频消融过程中产生的热量可以协同发挥TACE过程中注入化疗药物的疗效。因此TACE联合射频消融可提高肝细胞癌的疗效。本研究是第一项研究RFA联合TACE的前瞻随机对照研究,目的在于比较RFA联合或不联合TACE治疗肝细胞癌(HCC)的效果。方法此项单中心随机对照临床试验在中山大学肿瘤医院完成。自2006年10月至2009年6月,189例直径小于7 cm的肝细胞癌患者符合入选标准完成对照试验。入选标准:1年龄18~75岁;2HCC单个病灶≤7 cm,或3个或以下病灶,每个≤3 cm;3无影像学证据显示大血管侵犯且无肝外转移;4B超下可见病灶且病灶和腹壁之间有安全距离;5ECOG体力状态评分0;6之前未接受过HCC治疗;7患者Child-Pugh肝功能A或B级。患者随机接受TACE联合RFA治疗(TACE-RFA,n=94)或单纯RFA治疗(n=95)。该研究的主要终点为总体生存率,次要终点为无复发生存率,第三终点为不良事件。结果随访7至62月期间,TACE-RFA组死亡34例,复发33例;RFA组死亡48例,复发52例。TACE-RFA组与RFA组患者1年、3年及4年总体生存率分别为92.6%、66.6%、61.8%以及85.3%、59%和45.0%。两组对应的无复发生存率分别为79.4%、60.6%、54.8%以及66.7%、44.2%和38.9%。TACE-RFA组患者的总体生存率(RR=0.525,95%CI:0.335~0.822;P=0.002)以及无复发生存率(RR=0.575,95%CI:0.374~0.897;P=0.009)均优于RFA组患者。研究中未出现治疗相关死亡病例。Logistic回归分析显示,治疗分组、肿瘤大小以及肿瘤数量为患者总体生存率的显著预后因素,同时,治疗分组与肿瘤数量为患者无复发生存率的显著预后因素。结论对于直径小于7 cm的HCC患者,接受TACERFA较单纯RFA治疗生存获益更显著。Peng ZW Zhang YJ Chen MS 张信华 2013消化肿瘤杂志(电子版)2013,5,3:23
4急性ST段抬高型心肌梗死行急诊经皮冠状动脉介入治疗的二联和三联抗血小板治疗比较显示文摘在药物洗脱支架(DES)时代,对于急诊经皮冠状动脉介入治疗(PCI)的急性ST段抬高型心肌梗死(STEMI)患者,三联抗血小板治疗优于还是相同于二联抗血小板治疗?结论仍不明确。Chen KY Rha SW Li YJ 刘兵 2009中国心血管杂志2009,14,5:23
5Effect of extracorporeal bioartificial liver support system on fulminant hepatic failure rabbits显示文摘AIM To evaluate the possibility of usingcultured human hepatocytes as a bridge betweenbioartificial liver and liver transplantation.METHODS In this experiment,the efficacy ofextracorporeal bioartificial liver support system(EBLSS)consisting of spheriodal human livercells and cultured hepatocytes supernatant wasassessed in vivo using galactosamine inducedrabbit model of fulminant hepatic failure.RESULTS There was no difference of survivalbetween the two groups of rabbits,but in thesupported rabbits serum alanineaminotransferase,total bilirubin and creatininewere significantly lower and hepatocyte necrosiswas markedly milder than those in controlanimals.In addition,a good viability of humanliver cells was noted after the experiment.CONCLUSION EBLSS plays a biologic role inmaintaining and compensating the function ofthe liver.Wang YJ Li MD Wang YM Chen GZ Lu GD Tan ZX 2000World Journal of Gastroenterology2000,6,2:17
6醛固酮可通过NLRP3炎症小体诱导小鼠肝星状细胞活化和肝纤维化显示文摘【据《J Gastroenterol Hepatol》2020年6月报道】题:醛固酮通过NLRP3炎症小体诱导小鼠肝星状细胞活化和肝纤维化(作者Li Y等)已有证据表明,醛固酮和NLRP3炎症小体是诱导肝星状细胞活化以及肝纤维化的重要因素。然而,醛固酮与NLRP3炎症小体在肝星状细胞激活以及肝纤维化过程中是否存在相互作用,目前尚不清楚。该研究旨在探讨醛固酮与NLRP3炎症小体在调控肝星状细胞活化以及肝纤维化形成过程中的相互作用关系。LI Y ZHANG YJ CHEN TT 李洋 李旭 2020临床肝胆病杂志2020,36,8:7
7Antioxidant activity of polyphenols from seeds of Vitis amurvitro in vitro显示文摘Wang JN Chen YJ Hano Y 2000Acta Pharmacol Sin2000,21,:2
8Immunohistochemical detection of alatoxin B1 -DNA adducts and hepatitis B virus antigens in hepatocellular carcinoma and nontumorous liver tissue 显示文摘Santella RM Zhang YJ Chen CJ 1993Environ Health Perspect1993,99,:1
9Effects of root-end filling materials and eugenol on mitochondrial dehydrogenase activity and cytotoxicity to human periodontal ligament fibroblasts 显示文摘Lin CP Chen YJ Lee YL 2004J Biomed Mater Res B Appl Biomater2004,71,2:1
10Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1(ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB : structure-activity relationships 显示文摘Chen CC Chow MP Huang WC Lin YC Chang YJ 2004Mol Pharmacol2004,66,3:1
11Effects of rapid atrial pacing on the arrhythmo genic activity of single cardiomyocytes from pulmonary veins: implication in initiation of atrial fibrillation显示文摘Chen YJ Chen SA Chen YC 2001Circulation2001,104,23:1
12Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ 2010J Bone Miner Res2010,25,6:1
13Psychological stress delays periodontitis healing inRats:The involvement of basic fibroblast growth factor显示文摘Zhao YJ Li Q Chen YJ 0,,:1
14Aggravated cognitive and brain functional impairment in mild cognitive impairment patients with type 2 diabetes: a resting-state functional MRI study 显示文摘Zhou XQ Zhang JY Chen YJ 2014Journal of Alzheimer'' s Disease2014,41,3:1
15Effects of brain histamine on memorydeficit induced by nucleus basalis- 1esion in rats显示文摘Chen Z Shen YJ 2002ActaPharmacol Sin2002,23,1:1
16Oestrogen-induced epithelial-mesenchymal transition of endometrial epithelial cells contributes to the development of adenomyosis显示文摘Chen YJ Li HY Huang CH 2010J Pathol2010,222,3:1
17Serological survey of bovine herpesvirus type 1 infection in China显示文摘Yah BF Chao YJ Chen Z 2008Veterinary microbiology2008,127,1:1
18Classifying Ischemic Stroke, from TOAST to CISS 显示文摘Chen PH Gao S Wang YJ 2012CNS Neurosci Ther2012,18,6:1
19Long thermal effect of plused Nd:YAG laser irradiation on cultured human periodontal fibroblast显示文摘Chen YJ Jeng JH Jane YCC 2005Laser SurgMed2005,36,3:1
20Potential dental pulp revascularization and odonto-/osteogenic capacity of a novel transplant combined with dental pulp stem cells and platelet-rich fibrin显示文摘Chen YJ Zhao YH Zhao YJ 2015Cell Tissue Res2015,,:1
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