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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Progress on molecular breeding and metabolic engineering of biosynthesis pathways of C-30, C-35, C-40, C-45, C-50 carotenoids显示文摘 | Wang, F Jiang, JG Chen, Q | 2007 | 中国生物学文摘2007，21，10： | 4 |
| 3 | Changing trends of surgical treatment of hilar bile duct cancer:clinical and experimental perspectives显示文摘HISTORICAL POINT OF VIEWCarcinoma of the confluence of the hepatic ductshas been thought to be a rare disease until recently.Carcinoma of the large hepatic ducts was rarelydiagnosed correctly premorterned.Because of itsdeeply seated location,resection was once thoughtto be impossible.In 1957,Altemeier reported | Huang ZQ Zhou NX Wang DD Lu JG Chen MY | 2000 | World Journal of Gastroenterology2000，6，6： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Splenic vascular tumors:a histologic,immunophenotypic,and virologic study显示文摘 | Arber DA Strickler JG Chen YY | 1997 | Am J Surg Pathol1997，21，7： | 1 |
| 6 | Suppression of mitogenesis and regulation of cell cycle traverse by resveratrol in cultured smooth muscle cells 显示文摘 | Zou JG Huang YZ Chen Q | 1999 | Int J Oncol1999，15，： | 1 |
| 7 | bc1-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations显示文摘 | Chen J Flannery JG LaVail MM | 1996 | Proc Natl Acad Sci USA1996，93，14： | 1 |
| 8 | Effects of berberine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adduct formation in human leukemia cells显示文摘 | Chung JG Chen GW Hung CF | 2000 | Am J Chin Med2000，28，2： | 1 |
| 9 | Splenic vascular tumour:A histologic,immunohenotypic and virologic study显示文摘 | Arber DA Strickler JG Chen YY | | 0，，： | 1 |
| 10 | Interfacial stress analysis of a thin plate bonded to a rigid substrate and subjected to inclined loading显示文摘 | Yuan H Chen JF Teng JG | | 0，，16： | 1 |
| 11 | An association of UDP - glucu- ronosyltransferase 2B7 C802T (His268Tyr) polymorphism with bladder cancer in benzidine - exposed workers in China显示文摘 | Lin GF Guo WC Chen JG | 2005 | Toxicol Sci2005，85，： | 1 |
| 12 | Aberrant FHIT transcripts in hepatocellular carcinomas显示文摘 | Chen YJ Chen PH Chang JG | 1998 | Br J Cancer1998，77，3： | 1 |
| 13 | The pharmacokinetics, pharmacodynamics, and safety of orally dosed INCB018424 phosphate in healthy volunteers 显示文摘 | SHI JG CHEN X MCGEE RF | 2011 | J Clin Pharmacol2011，51，12： | 1 |
| 14 | Reconsidering Baron and Kenny:myths and truths about mediation analysis显示文摘 | Zhao X Lynch JG Chen Q | 2010 | J Consumer Res2010，37，2： | 1 |
| 15 | FRP-to-concrete interfaces between two adjacent cracks:Theoretical model for debonding failure显示文摘 | Teng JG Yuan H Chen JF | | 0，，18： | 1 |
| 16 | Glutathione S-transferases M1 and T1 polymorphisms and arsenic content in hair and urine in two ethnic clans exposed to indoor combustion of high arsenic coal in South- west Guizhou, China 显示文摘 | Lin GF Du H Chen JG | 2007 | Arch Toxico12007，81，8： | 1 |
| 17 | The Acid-activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory显示文摘 | Wemmie JA Chen JG Askwith CC | 2002 | Neuron(S0896--6273)2002，34，3： | 1 |
| 18 | Screening for liver cancer:results of a randomised controlled trial in Qidong,China显示文摘 | Chen JG Parkin DM Chen QG | 2003 | J Med Screen2003，10，4： | 1 |
| 19 | Relation between hospital intra - aortic balloon counterpulsation volume andmortality in acute myocardial infarction complicated by cardiogenic shock 显示文摘 | Chen EW Canto JG Parsons LS | 2003 | Circulation2003，108，8： | 1 |
| 20 | Liver cancer epidemic in China:past,present and future显示文摘 | Chen JG Zhang SW | 2011 | Semiu Cancer Biol2011，21，1： | 1 |
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