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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Drained,undrained,consolidating and dynamic behaviour assumptions in solis; Limits of validity 显示文摘 | Zienkiewicz O C Chang C T Bettess P | 1980 | Geotechnique1980，30，： | 2 |
| 3 | Expandion of Philadephia chromosome-negative CD3+CD56+cytotoxic cells from chronic myeloid leukaemia patients:in vitro and in vivo efficacy in severe combined immunodeficiency disease mice显示文摘 | Hoyle C Bangs CD Chang P | 1998 | Blood1998，92，9： | 2 |
| 4 | A fuzzy case-based reasoning model for sales forecasting in print circuit board industries显示文摘 | CHANG P C LIU C H LAIR K | 2008 | Expert Systems with Applications2008，34，3： | 1 |
| 5 | Observations on changes in ultrasonically treated waste-activated sludge显示文摘 | Chu C P Chang B V Liao G S | 2001 | Wat Res2001，35，4： | 1 |
| 6 | The flavonoid baicalin protects against cerebrovascular dysfunction brain inflammation in experimental heatstroke显示文摘 | Chang C P Huang W T Cheng B C | 2007 | Neuroparmacology2007，52，： | 1 |
| 7 | Surface Status and Size Influences of Nickel Nanoparticles on Sulfur Compound Adsorption 显示文摘 | Chang H K Jung G P Ji C P | 2007 | Applied Surface Science2007，253，13： | 1 |
| 8 | A quick evaluating method for automotive fuel cell lifetime 显示文摘 | PEI P C CHANG Q F TANG T | 2008 | International Journal of Hydrogen Energy2008，33，： | 1 |
| 9 | SVD-based digital image watermarking scheme显示文摘 | CHANG C C TSAI P Y LIN C C | 2005 | Pattern Recognition Letters2005，26，： | 1 |
| 10 | Methylation and acetylation characteristics of cloned bovine embryos from donor cells treat with 5-aza-2' deoxyeytidine 显示文摘 | Enright B P Sung L Y Chang C C | 2005 | Biol Reprod2005，72，4： | 1 |
| 11 | Variable scaling hybrid differential evolution for solving network reconfiguration of distribution systems显示文摘 | Chiou J P Chang C F Su C T | 2005 | IEEE Trans on Power Systems2005，20，2： | 1 |
| 12 | Modeling VOCs adsorption onto activated carbon 显示文摘 | C L Chuang P C Chiang and E E Chang | 2003 | Chemosphere2003，53，1： | 1 |
| 13 | Management of facial nerve injury due to temporal trauma显示文摘 | Chang C Y J Stephen P C | 1999 | Am J Otol1999，20，： | 1 |
| 14 | 显示文摘 | Jeong J Choi S P Chang C I | 2003 | Solid State Communieations2003，127，： | 1 |
| 15 | Comparative effects of polyunsaturated to saturated fatty acid ratio versus polyunsaturated and monounsaturat- ed fatty acid ratio versus polyunsaturated and monounsaturated fatty acid to saturated fatty acid ratio on lipid metabolism in rats 显示文摘 | Chang N W Huang P C | 1999 | Atherosclerosis1999，142，1： | 1 |
| 16 | Identification and subtyping of avian influenza viruses by reverse tran-scription-PCR 显示文摘 | Lee M S Chang P C Shien J H | 2001 | J Virol Methods2001，97，12： | 1 |
| 17 | Finite ele- ment evaluation of the state of cure in a tire 显示文摘 | TOTH W J CHANG J P ZANICHELLI C | 1991 | Tire Science and Technology1991，19，4： | 1 |
| 18 | Micromechanical analysis of kinematic hardening in natural clay显示文摘 | YIN Z Y CHANG C S HICHER P Y | 2009 | International Journal of Plasticity2009，25，8： | 1 |
| 19 | Synthesis of large surface area carbon xerogels for electrochemical double layer capacitors显示文摘 | Chang Y M Wu C Y Wu P W | 2013 | J Power Sources2013，223，： | 1 |
| 20 | Correlation of diffusion coefficients in dilute solutions显示文摘 | WILKE C R CHANG P | 1955 | AICh[J1955，1，2： | 1 |
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