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| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | Remote sensing of global wetland dynamics with multiple satellite data sets显示文摘 | Catherine P Elaine M Filipe A | 2001 | Geophysical Researeh Letters2001，28，15： | 1 |
| 3 | A recombinant fowl adenovirus expressing the S1 gene of infectious bronchitis virus protects against challenge with infectious bronchitis virus 显示文摘 | Michael A Catherine P Jagoda I | 2003 | Vaccine2003，21，： | 1 |
| 4 | Socioeconomic status in health research: title and subtitle break one size doos not fit all显示文摘 | Paula A Braveman M M Catherine Cubbiu P Susan Ege-ler P et at | 2005 | jama-Journal of the American Medical Association2005，294，22： | 1 |
| 5 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 6 | DUROS technology delivers peptides and proteins at consistent rate continuously for 3 to 12 months 显示文摘 | Catherine M R Thomas R A Bing Y Janice D John P C Scott D L | 2008 | Journal of Diabetes Science and Technology2008，2，3： | 1 |
| 7 | Separable gating mechanisms in a mammalian pacemaker channel 显示文摘 | Vincenzo M Catherine P Eugene A | 2002 | J Biol Chem2002，277，35： | 1 |
| 8 | Carbon isotopes as tracers of dissolved organic carbon sources and water pathways in headwater catchments显示文摘 | Lambert T Catherine A Wickmann P | | 0，，： | 1 |
| 9 | Pancroatitis-associated acute lung injury:new insights显示文摘 | CATHERINE M P MICHAEL A M JEAN-LOUIS F | 2003 | Chest2003，124，6： | 1 |
| 10 | Trade Facilitation:A Development Perspective in the Asia Pacific Region 显示文摘 | JOHN S W CATHERINE M YUEN P W NIZAR A INBOM C | 2002 | Asia Pacific Economic Cooperation2002，，10： | 1 |
| 11 | The metabolic fate of dietary polyphenols in humans显示文摘 | Andreas R Rechner Gunter Kuhnle Paul Bremner Gary P Hubbard Kevin P Moore Catherine A Rice-Evans | 2002 | Free Radical Biology and Medicine2002，，2： | 1 |
| 12 | An mRNA encoding a response regulator protein from Brassica napus is up-regulated during pod development显示文摘 | Catherine A W Wyatt P Elizabeth S J | 1999 | Journal of Experimental Botany1999，50，： | 1 |
| 13 | Interaction of lead and chromium with chitin and chrosan显示文摘 | CATHERINE A E CAROLYN A J WIGHTMAN J P | 1980 | Journal of Applied Polymer Science1980，25，： | 1 |
| 14 | Antioxidant Properties of Phenolic compounds显示文摘 | Catherine A R-E Nicolas J M George P | 1997 | Trends in Plant Science1997，2，4： | 1 |
| 15 | Antioxidant Prop-erties of Phenolic Compounds 显示文摘 | Catherine A R-E Nicolas J M George P | 1997 | Trends in Plant Science1997，2，4： | 1 |
| 16 | Subgroup Analysis of Symptoms and Their Effect on Functioning, Exercise Capacity, and Physical Activity in Patients with Severe Chronic Obstructive Pulmonary Disease 显示文摘 | Soo K P Catherine A M Janet L L | 2013 | Heart & Lung: The Journal of Acute and Critical Care2013，42，6： | 1 |
| 17 | Dual role of phosphofructokinase-2/frnctose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes 显示文摘 | VICTORIA P CATHERINE A WU CHD | 2005 | Diabetes2005，54，7： | 1 |
| 18 | Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes显示文摘 | Victoria P Catherin A Wu Ch D | 2005 | Diabetes2005，54，7： | 1 |
| 19 | Improving the nutritional value of golden rice through increased pro-vitamin A content显示文摘 | Jacqueline A P Catherine A S Sunandha C | 2005 | Nature Biotechnology2005，23，： | 1 |
| 20 | Reinvestigation of epoxidation using tungsten-based precursors and hydrogen peroxide in a biphase medium显示文摘 | CATHERINE A GENEVIEVE C NICOLE P JEAN-MARIE B RENE T FRANCOISE C CATHERINE H HENRY L | 1991 | Inorg Chem1991，30，23： | 1 |
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