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| 1 | Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats显示文摘AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P < 0.0001). The distance traveled by a mark-er, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20% ± 2% in comparison with 25.9% ± 1.64% in rats that re-ceived ketamine (P = 0.017). BER was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion. | Carlos Rodrigo Cámara Francisco Javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando Garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer | 2008 | World Journal of Gastroenterology2008，14，33： | 5 |
| 2 | The intron of the Arabidopsis thaliana COX5 c gene is able to improve the drought tolerance conferred by the sunflower Hahb4 transcription factor显示文摘 | CABELLO J V DEZAR C A MANAVELLA P A | 2007 | Planta2007，226，： | 1 |
| 3 | Differing roles for platelet-activating factor during inflammation of the lung and subarachnoid space 显示文摘 | MacIntyre D E Forresto M | 1992 | J Clin Invest1992，90，2： | 1 |
| 4 | Impact of the preservation of the intercostobrachial nerve in axillary lymphadenectomy due to breast cancer显示文摘 | Torresan RZ Cabello C Conde DM | 2003 | Breast J2003，9，5： | 1 |
| 5 | Impact of the preservation of the intercosto- brachial nerve in axillary lymphadenectomy due to breast cancer 显示文摘 | Torresan RZ Cabello C Conde DM | 2003 | Breast J2003，9，5： | 1 |
| 6 | The candidate for renal transplantation work up: medical, urological and oneologieal evaluation 显示文摘 | CABELLO B R QUICIOS D C LOPEZ M L | 2011 | Arch Esp Urol2011，64，5： | 1 |
| 7 | Impact of the preservation of the intercostobrachial nerve in ax- illary lymphadenectomy due to breast cancer 显示文摘 | Torresan RZ Cabello C Conde DM | 2003 | Breast J2003，9，5： | 1 |
| 8 | Differing role for platelet activating factor during inflammation of the lung and subarachnoid space显示文摘 | Cabellos C Macln TDE Forresto M | 1992 | J Clin Inuest1992，90，2： | 1 |
| 9 | Impact of the preservation of theintercostobrachial nerve in axillary lymphadenectomy due to breast cancer显示文摘 | Torresan RZ Cabello C Conde DM | 2003 | Breast J2003，9，5： | 1 |
| 10 | Differing roles for platelet-activating factor during TNFlammation of the lung and subarachnoid space显示文摘 | Cabellos C Macintyre DE Forrest M | 1992 | J Clin Invest1992，90，2： | 1 |
| 11 | Multiple gene copy number enhances insulin precursor secretion in the yeast Pichia pastoris显示文摘 | Mansur M Cabello C Hernández L | | 0，，05： | 1 |
| 12 | Heavy use of prophylactic antibiotics in aquaculture: a growing problem for human and animal health and for the environment 显示文摘 | CABELLO F C | 2006 | Environ Microblo12006，8，： | 1 |
| 13 | Experimental study of the efficacy of vancomycin, rifampicin and dexamethas- one in the therapy of pneumococcal meningitis 显示文摘 | Martinez-Lacasa J Cabellos C Martos A | 2002 | Journal of Antimicrobial Chemotherapy2002，49，3： | 1 |
| 14 | Enterococcal meningitis: a clinical study of 39 cases and review of the literature显示文摘 | Pintado V Cabellos C Moreno S Meseguer MA Ayats J Viladrich PF | 2003 | Medicine (Baltimore)2003，82，5： | 1 |
| 15 | Multiple gene copy number enhances insulin precursor secretion in the yeast Pichia pastoris显示文摘 | Mansur M Cabello C Hernández L | | 0，，05： | 1 |
| 16 | Impact of the preservation of the intercostobrachial nerve in axillary lymphadenectomy due to breast cancer 显示文摘 | Torresan RZ Cabello C Conde DM | 2003 | Breast J2003，9，5： | 1 |
| 17 | Impact of the preservation of the intercostobrachial nerve in axillary lymphadenectomy due to breast cancer显示文摘 | Torresan RZ Cabello C Conde DM | 2003 | Breast J2003，9，5： | 1 |
| 18 | Case report and review of the literature: Secretory breast cancer in a 13-year-old boy-10 years of follow up显示文摘 | Cabello C Alvarenga M Alvarenga CA | 2012 | Breast Cancer Res Treat2012，133，3： | 1 |
| 19 | Enterococcal meningitis, a clinical study of 39 cases and review of the literature 显示文摘 | Pintado V Cabellos C Moreno S | 2003 | Medicine2003，82，： | 1 |
| 20 | Metabotropic gluta- mate type 5,dopamine D2 and adenosine A2a receptors form higher order oligomers in living cells显示文摘 | Cabello N Gandla J Bertarelli D C | 2009 | J Neurochem2009，109，5： | 1 |
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