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| 1 | Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome显示文摘Polycystic ovary syndrome(PCOS) is the most common endocrine disorder in reproductive-aged women. Women with PCOS frequently have metabolic complications including insulin resistance(IR), early diabetes, hypertension and dyslipidemia. Recent studies have demonstrated an association between PCOS and another metabolic complication: nonalcoholic fatty liver disease(NAFLD). NAFLD occurs as a result of abnormal lipid handling by the liver, which sensitizes the liver to injury and inflammation. It can progress to nonalcoholic steatohepatitis(NASH), which is characterized by hepatocyte injury and apoptosis. With time and further inflammation, NASH can progress to cirrhosis. Thus, given the young age at which NAFLD may occur in PCOS, these women may be at significant risk for progressive hepatic injury over the course of their lives. Many potential links between PCOS and NAFLD have been proposed, most notably IR and hyperandrogenemia. Further studies are needed to clarify the association between PCOS and NAFLD. In the interim, clinicians should be aware of this connection and consider screening for NAFLD in PCOS patients who have other metabolic risk factors. The optimal method of screening is unknown. However, measuring alanine aminotransferase and/or obtaining ultrasound on high-risk patients can be considered. First line treatment consists of lifestyle interventions and weight loss, with possible pharmacologic interventions in some cases. | Carly E Kelley Ann J Brown Anna Mae Diehl Tracy L Setji | 2014 | World Journal of Gastroenterology2014，20，39： | 11 |
| 2 | 板块构造机制在显生宙初期发生转变显示文摘虽然目前对于板块构造何时成为主要构造机制存在争议,但是研究者普遍认为在古太古代已经完成转变。元古代时期,哥伦比亚超大陆向罗迪尼亚超大陆的转换,并未发生超大陆的完全裂解和聚合,而是岩石圈和环境的相对稳定期。相比之下,成冰期至今则发育有大量的被动大陆边缘,以及在425~225 Ma期间大幅增加的裂谷和大陆岛弧长度,表明存在与潘吉亚超大陆形成密切相关的激烈板块构造活动。 | 袁超(编译) Brown M Kirkland C L Johnson T E | 2020 | 矿物岩石地球化学通报2020，39，4： | 9 |
| 3 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 4 | Isolation of protein products from chromium containing leather waste using two consecutive enzymes and purification of final chromium product: pilot plant studies 显示文摘 | Brown E M Cabeza L F Taylor M M | 1999 | JSL TC1999，，83： | 1 |
| 5 | Recombinant DNA procedures for producing small antimicrobial cationic peptides in bacteria显示文摘 | PIERS K L BROWN M H HANCOCK R E W | 1993 | Gene1993，134，1： | 1 |
| 6 | Ethi cal Leadership: A Social Learning Perspective for Construct Development& Testing显示文摘 | BROWN M E TREVIN L K HARRISON D | 2005 | Organizational Behavior & Human Decision Processes2005，97，2： | 1 |
| 7 | Lack of significant correlation between rhinosinusiris symptoms and specific regions of sinus computer tomography scans显示文摘 | HOLBROOK E H BROWN C L LYDEN E R | 2005 | Am J Rhinol2005，19，： | 1 |
| 8 | Myxoid neoplasms of the adrenal gland显示文摘 | Brown F M Gaffey T A Wold L E | 2000 | Am Surg Pathol2000，24，3： | 1 |
| 9 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 10 | Low-temperature friction-stir welding of 2024 aluminum 显示文摘 | BENAVIDES S LI Y MURR L E BROWN D McCLURE J C | 1999 | Scripta Materialia1999，41，： | 1 |
| 11 | Analyzingthe reliability impact of distributed generation显示文摘 | BROWN R E FREEMAN L A A | 2011 | Proceedings of the IEEE Summer Meeting2011，，7： | 1 |
| 12 | Irrigating crops with Seawater 显示文摘 | GLENN E P BROWN J J O'L EARY J W | 1998 | Scientific American1998，，8： | 1 |
| 13 | Nursing Practice, Knowledge, Attitudes and Perceived Barriers to Evidence- Based Practice at an Academic Medical Center显示文摘 | Brown C E Wickline M A Ecoff L | 2009 | J Adv Nurs2009，65，2： | 1 |
| 14 | A new approach for the recovery of precious metals from solution and from leachates derived from electronic scrap 显示文摘 | Maeaskie L E Creamer N J Essa A M M Brown N L | 2007 | Biotechnology and Bioengineering2007，96，4： | 1 |
| 15 | Enhanced root-to-shoot translocation of cadmium in the hyperaccumulating ecotype of Sedum alfredii 显示文摘 | Lu L L Tian S K Yang X E Wang X C Brown P Li T Q He Z L | 2008 | Journal of Experimental Botany2008，59，11： | 1 |
| 16 | The principle of additivity and the proeutectoid ferrite transformation 显示文摘 | Hawbolt E B Brown L C | 1992 | Metall Trans A1992，23，9： | 1 |
| 17 | Microarray analysis of murine palato-genesis:temporal expression of genes during normal palatedevelopment显示文摘 | BROWN N L KNOTT L HALLIGAN E | 2003 | Dev Growth Differ2003，45，： | 1 |
| 18 | Hamstring tendon grafts for reconstruction of the anterior cruciate ligament:biomechanical evaluation of the use of multiple strands and tensioning techniques显示文摘 | Hamner D L Brown C H Jr Steiner M E | 1999 | J Bone Joint Surg Am1999，81，4： | 1 |
| 19 | Change in inpatient re- habilitation admissions for individuals with traumatic brain injury af- ter implementation of the medicare inpatient rehabilitation facility prospective payment system显示文摘 | Hoffman JM Donoso Brown E Chan L | 2012 | Arch Phys Med Rehabil2012，93，8： | 1 |
| 20 | Association between timeliness of reperfusion therapy and clinical outcomes in ST -elevation myocardial infarction显示文摘 | Lambert L Brown K Segal E | 2010 | JAMA2010，303，21： | 1 |
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