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| 1 | 水解蛋白质化学改性(英文)显示文摘从含铬废弃物提取的水解蛋白质与不同量的戊二醛 ,在不同的温度下反应。用聚酰胺凝胶电泳法 (SDS -PAGE)分析了改性蛋白质的分子量及分子量分布。用CanonManning粘度法测定了改性产物的粘度。实验表明改性产物的分子量随戊二醛的用量增加而增加。最佳的戊二醛用量约为水解胶原质量的 12 % ,反应温度大于 6 0℃。同时 ,用改性产物做了皮革的填充实验 ,用萤光标记改性胶原 ,通过扫描电镜研究了填充皮革的纤维结构。研究结果表明 ,改性产物具有较好的填充性能 ,采用适当的应用工艺 ,改性产物可能用作皮革填充剂。 | 陈武勇 Brown E M Taylor M M Cooke P H Marmer W N | 2002 | 四川大学学报(工程科学版)2002，34，6： | 9 |
| 2 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 3 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 4 | B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy显示文摘 | Vijay K Kuchroo Mercy Prabhu Das Julia A Brown Ann M Ranger Scott S Zamvil Raymond A Sobel Howard L Weiner Nasrin Nabavi Laurie H Glimcher | 1995 | Cell1995，，5： | 2 |
| 5 | Invasive fungal infections:a review of epidemiology and management options 显示文摘 | ENOCH V A LUDLAM H A BROWN N M | 2006 | J Med Microbiol2006，55，7： | 1 |
| 6 | Recombinant DNA procedures for producing small antimicrobial cationic peptides in bacteria显示文摘 | PIERS K L BROWN M H HANCOCK R E W | 1993 | Gene1993，134，1： | 1 |
| 7 | Laminin-binding integrins in rat lens morpho- genesis and their regulation during fibre differentiation显示文摘 | WedereU ED Brown H O' Connor M Chamberlain CG McAvoy JW de Iongh RU | 2005 | Exp Eye Res2005，81，3： | 1 |
| 8 | Effect of chain rigidity and effective conjugation length on the structural and photophysical properties of pyridine - based luminescent polymers 显示文摘 | Tammer M Horsburgh L Monkman A P Brown W Burrows H D | 2002 | Advanced Functional materials2002，12，： | 1 |
| 9 | Millibot trains for enhanced mobility显示文摘 | Brown H B Weghe M Bererton C | 2002 | IEEE/ASM Trails Mechatronlcs2002，6，4： | 1 |
| 10 | Mitochon- drial DNA phylogeny of the Prodoxidae ( Lepidoptera: Incurvari- oidea) indicates rapid ecological diversification of yucca moths 显示文摘 | BROWN H M PELLMYR O THOMPSON J N | 1994 | Annals of the Entomological Society of America1994，37，6： | 1 |
| 11 | Rates of chemical de- nudation and CO2 drawdown in a glacier-covered alpine catch- ment显示文摘 | Sharp M Tranter M Brown G H | 1995 | Geology1995，23，1： | 1 |
| 12 | Tree allometry and improved estimation of carbon stocks and balance in tropical forests显示文摘 | Chave J Andalo C Brown S Cairns M A Chambers J Q Eamus D Folster H Fromard F Higuchi N Kira T Lescure J P Nelson B W Ogawa H Puig H Riera B Yamakura T | | 0，，： | 1 |
| 13 | Proton dependent mul- tidrug efflux systems显示文摘 | Paulsen I T Brown M H Skurray R A | 1996 | Microbiol Rev1996，60，4： | 1 |
| 14 | Neural processes associated with antisaccade task performance investigated with event- related fMRI显示文摘 | FORD K A GOLTZ H C BROWN M R G | 2005 | Journal of Neurophysiology2005，94，1： | 1 |
| 15 | Discriminative learning of local image descriptors显示文摘 | BROWN M GANG H WINDER S | 2011 | IEEE Transactions on Pattern Anal- ysis and Machine Intelligence2011，33，1： | 1 |
| 16 | Visualization in Scientific Computing显示文摘 | B H McCormick T A DeFanti M D Brown | 1987 | Computer Graphics1987，，6： | 1 |
| 17 | A new class of sufficient conditions for first order approach to principal agent problem 显示文摘 | Brown M Chiang S H Ghosh S | 1986 | Economics Letters1986，21，： | 1 |
| 18 | A simple general synthesis of 1-alkynyldiisop ropoxyboranes 显示文摘 | Brown H C Bhat N G Srebnik M | 1988 | Tetrahedron Letters1988，29，22： | 1 |
| 19 | Uniqueness in the Inverse Conductivity Problem for Conductivities with 3/2 Derivatives in L forp >2n 显示文摘 | Brown R M Tortes R H | 2003 | J Fourier Anal Appl2003，9，： | 1 |
| 20 | Biochemistry of the coccidian显示文摘 | COOMBS G H DENTON H BROWNS M | 1997 | Adv Parasitol1997，39，： | 1 |
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