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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | 跟骨关节内移位骨折的功能疗效和患者满意度——切开复位、经皮手术和非手术治疗对比研究显示文摘对于跟骨关节内移位骨折,约60%的工薪阶层患者会选择切开复位内固定术(openreductionandinternalfixation,ORIF)治疗,术后恢复工作通常需要5~10个月,相当一部分患者1年内无法恢复工作;而对于保守治疗患者,骨折症状通常会持续1~2年,高达16%的患者需行关节内固定手术。本研究的主要目的是比较3种跟骨关节内移位骨折治疗方案——ORIF、经皮手术和非手术治疗的疗效差异。 | De Boer AS Van Lieshout EM Den Hartog D 叶翔凌 夏远军 | 2016 | 中国骨科临床与基础研究杂志2016，8，6： | 2 |
| 3 | Agricultural nutrient losses to surface water in the Netherlands:Impact, strategies, and perspectives显示文摘 | Van Der Molen D T Breeuwsma A Boers P C M | 1998 | Journal of Environmentol Quality1998，27，1： | 1 |
| 4 | The 1994 QUASIMEME laboratory performance studies: Chlorobiphenyls and organo-chlorine pesticides in fish and sediment显示文摘 | Jacob D E Boer | 1996 | Marine pollution Bulletin1996，32，89： | 1 |
| 5 | The effect of phosphorus on the formation of hyphae in soil by vesicular mycorrhizal fungus ,Glomus fasciculatum显示文摘 | Abbott L K Robson A D Boer G | 1984 | New phytologist1984，97，： | 1 |
| 6 | Re cent sedimentation and sediment accumulation rates of the Ba Lat prodelta(Red River, Vietnam) 显示文摘 | van den Bergh G D Boer W Schaapveld M A S | 2007 | Journal of Asian Earth Sciences2007，，29： | 1 |
| 7 | Mesh deformation based on radial basis function interpolation显示文摘 | Boer A D Schoot V D Bijl H | 2007 | Computers and Structures2007，85，1114： | 1 |
| 8 | Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylarnine ( 2C-B ) in mice after acute administration 显示文摘 | Carmo H Boer D D Remiao F | 2004 | J Chromatogr B2004，811，： | 1 |
| 9 | Dynamics of Hiv Infection of CD4^+ T Cells显示文摘 | RERELSON A S KIRSCHNER D E BOER D R | 1993 | Mathematical Bioscial1993，114，1： | 1 |
| 10 | Proteinuria is preceded by decreased nitric oxide synthesis and prevented by a Nodonor in cholesterol-fed rats显示文摘 | Attia D M Ni Z N Boer P | 2002 | Kidney Int2002，61，5： | 1 |
| 11 | Chronic granulomatous disease caused by mutations other than the common GT deletion in NCF1, the gene encoding the p47phox component of the phagocyte NADPH oxidase 显示文摘 | Roos D de Boer M Yavuz KM | 2006 | Human Mutation2006，27，12： | 1 |
| 12 | A DPA attack againstthe modular reduction within a CRT implementation ofRSA显示文摘 | Boer B D Lemke K Wicke G | 2003 | Computer Science2003，，2523： | 1 |
| 13 | Formation, Stability, and Properties of In-situ Composites Based on Blends of a Thermotropic Liquid Crystalline Polymer and a Thermoplastic Elastomer显示文摘 | A G C Machiels K F J Denys J Van Dam A P D Boer | 1996 | Polymer Engineering and Science1996，36，19： | 1 |
| 14 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 15 | Co-evolution of firm absorptive capacity and knowledge environment:organizational forms and combinative capabilities显示文摘 | BOSCH F A J V VOLBERDA H W BOER M D | 1999 | Organization Science1999，10，5： | 1 |
| 16 | Dual role for 14-3-3 proteins and ABF transcription fac- tors in gibberellic acid and abscisic acid signalling in barley (Hordeum vulgare) aleurone cells 显示文摘 | SCHOONHEIM P J COSTA PEREIRA D D DE BOER A H | 2009 | Plant Cell Envi- ron2009，32，5： | 1 |
| 17 | Metabolic pathways of 4-bromo - 2, 5-dimethoxyphenethylamine ( 2C- B) : analysis of phase I metabolism with hepatocytes of of six species including human显示文摘 | Carmo H Hengstler J G Boer D D | 2005 | Toxicol2005，206，： | 1 |
| 18 | A no- vel,simplified ex vivo method for measuring water ex- change performance of heat and moisture exchangers for tracheostomy application显示文摘 | van den Boer C Muller S H Vincent A D | 2013 | Respir Care2013，58，9： | 1 |
| 19 | Agricultural nutrient losses to surface water in the Neth- erlands: impact, strategies, and perspectives 显示文摘 | VAN DER MOLEN D T BREEUWSMA A BOERS P C M | 1998 | Journal of Environmental Quality1998，27，： | 1 |
| 20 | Co-evolution of Firm Absorptive Capacity and Knowledge Environment: Organizational Forms and Combinative Capabilities显示文摘 | BoschF A J V D Volberda H W Boer M D | 1999 | ERIM Top-Core Articles1999，10，5： | 1 |
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