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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Characterization of the Landsat-7 ETM Automated Cloud-Cover Assessment(ACCA)Algorithm显示文摘 | Richard R Irish J L Barker S N | 2006 | Photogrammetric Engineering&Remote Sensing2006，72，10： | 1 |
| 3 | Modeling the Thermal Protective Performance of Heat Resist- ant Garments in Flash Fire Exposures 显示文摘 | SONG G Barker R L Hamouda H | 2004 | Textile Research Journal2004，74，12： | 1 |
| 4 | Heat and moisture transfer trough nonwoven fabrics 显示文摘 | WOO S S SHALEV Itzhak BARKER R L | 1994 | Journal of Textile Research1994，64，3： | 1 |
| 5 | Laser interferometer for measureing high velocities of any reflecting surface显示文摘 | Barker L M Hollenback R E | 1972 | Journal of Applied Physics1972，43，11： | 1 |
| 6 | Laser Interferometer for Measuring High Velocities of Any Reflecting Surface 显示文摘 | Hollenback R E | 1972 | J Appl Phys1972，43，11： | 1 |
| 7 | Dynamic Quasi-isentropic Loading of Tungsten显示文摘 | Asay J R Barker L M | 1990 | High Pressure Research1990，5，： | 1 |
| 8 | Liberation of staling aldehydes during storage of beer 显示文摘 | Barker R L Gracey D E F Irwin A J Pipasts P Leiska E | 1983 | J Inst Brew1983，89，： | 1 |
| 9 | Generating i PSCs:translating cell reprogramming science into scalable and robust biomanufacturing strategies显示文摘 | Silva M Daheron L Hurley H Bure K Barker R Carr AJ | 2015 | Cell Stem Cell2015，16，1： | 1 |
| 10 | Influences of organic and synthetic soil fertility amendments on nematode trophic groups and community dynamics under tomatoes显示文摘 | Bulluck L R Barker K R Ristaino J B | 2002 | Applied Soil Ecology2002，21，2： | 1 |
| 11 | Subcellular optochemical nanobiosensors: probes encapsulated by bilogically localised embedding (PEBBLES)显示文摘 | CLARK H A BARKER S L R BRASUEL M | 1998 | Sens Actuators B1998，51，： | 1 |
| 12 | Laser Interferometer for Measuring High Velocities of any Reflecting Surface 显示文摘 | Hollenbach R E | 1970 | J Appl Phys1970，41，： | 1 |
| 13 | Laser interferometer for measuring high velocities of any reflecting surface显示文摘 | Barker L M Hollenbaek R E | 1972 | Journal of Applied Physics1972，43，： | 1 |
| 14 | Biotransformation of BTEX under anaerobic denitrifying conditions显示文摘 | LEMON L A BARBARO J R BARKER J F | 1989 | Evaluation of Field Observation1989，10，： | 1 |
| 15 | Shock Wave Studies of PMMA,Fused Silica and Sapphire显示文摘 | Hollenbach R E | 1970 | Journal of Applied Physics1970，41，： | 1 |
| 16 | Magnetic stimulation of the human brain and peripheral nervous system: an introduction and the results of an initial clinical evaluation显示文摘 | Barker A T Freeston I L Jalinous R | 1987 | Neurosurgery1987，20，1： | 1 |
| 17 | Professional vital bleaching using a thin and concentrated peroxide gel on whitening strips: anintegrated clinical summary显示文摘 | Gerlach R W Barker M L | 2004 | J Contem Dent Prac2004，5，1： | 1 |
| 18 | Laser interferometer for measuring high velocities of any reflecting surface 显示文摘 | Barker L M Hollenback R E | 1972 | J Appl Phy1972，43，： | 1 |
| 19 | Laser interferometer for measuring high velocities of any refleeting surfaee显示文摘 | Barker L M Hollenback R E | 1972 | J Appl Phy1972，43，11： | 1 |
| 20 | Laser Interferometer for Measuring High Velocities of Any Reflecting Surface显示文摘 | Hollenbach R E | 1972 | Journal of Applied Physics1972，43，11： | 1 |
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