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| 1 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 2 | Impact of laparoscopic surgery training laboratory on surgeon's performance显示文摘Minimally invasive surgery has been replacing the open standard technique in several procedures. Similar or even better postoperative outcomes have been described in laparoscopic or robot-assisted procedures when compared to open surgery. Moreover, minimally invasive surgery has been providing less postoperative pain, shorter hospitalization, and thus a faster return to daily activities. However, the learning curve required to obtain laparoscopic expertise has been a barrier in laparoscopic spreading. Laparoscopic surgery training laboratory has been developed to aid surgeons to overcome the challenging learning curve. It may include tutorials, inanimate model skills training(box models and virtual reality simulators), animal laboratory, and operating room observation. Several different laparoscopic courses are available with specific characteristics and goals. Herein, we aim to describe the activities performed in a dry and animal-model training laboratory and to evaluate the impact of different kinds of laparoscopic surgery training courses on surgeon's performance. Several tasks are performed in dry and animal laboratory to reproduce a real surgery. A short period of training can improve laparoscopic surgical skills, although most of times it is not enough to confer laparoscopic expertise for participants. Nevertheless, this short period of training is able to increase the laparoscopic practice of surgeons in their communities. Full laparoscopic training in medical residence or fellowship programs is the best way of stimulating laparoscopic dissemination. | Fabio C M Torricelli Joao Arthur B A Barbosa Giovanni S Marchini | 2016 | World Journal of Gastrointestinal Surgery2016，8，11： | 6 |
| 3 | Psychotropic drugs and liver disease:A critical review of pharmacokinetics and liver toxicity显示文摘The liver is the organ by which the majority of sub-stances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first--pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity. | Diogo Telles-Correia António Barbosa Helena Cortez-Pinto Carlos Campos Nuno B F Rocha Sérgio Machado | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 3 |
| 4 | Improving hierarchical cluster analysis: a new method with outlier detection and automatic clustering显示文摘 | ALMEIDA J A S BARBOSA L M S PAIS A A C C | 2007 | Chemometrics and Intelligent Labora- tory Systems2007，87，2： | 1 |
| 5 | DNA binding- dependent and - independent functions of the Hand2 transcription factor during mouse embryogenesis显示文摘 | LIU N BARBOSA A C CHAPMAN S L | 2009 | Development2009，136，6： | 1 |
| 6 | Prevalance of anemia and its association with cardio-renal syndrome显示文摘 | Silva R P Barbosa P H Kimura O S | | 0，，02： | 1 |
| 7 | Hepatic photosensitization in buffaloes intoxicated by Bra- chiaria decumbens in Minas Gerais state, Brazil显示文摘 | De Oliveira C H S Barbosa J D Oiiveira C M C | 2013 | Toxi- con2013，73，： | 1 |
| 8 | Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil显示文摘 | Pouria S de Andrade A Barbosa J | 1998 | Lancet1998，352，： | 1 |
| 9 | Polypropylene/Polystyrene Blends: In Situ Compatibilization by Friedel-Crafts Alkylation Reaction 显示文摘 | Diaz M F Barbosa S E Capiati N | 2004 | Journal of Polymer Science: Part B: Polymer Physics2004，42，： | 1 |
| 10 | Effect of carotenoid source and dietary lipid content on blood astaxanthin concentration in rainbow trout ( Oncorhynehus mykiss) 显示文摘 | BARBOSA M J MORAl S R CHOUBERT | 1999 | Aquaculture1999，176，34： | 1 |
| 11 | Screening of yeasts for production of xylitol from D-xylose and some factors which affect xylitol yield in Candida guilliermondii显示文摘 | BARBOSA M F S MEDEIROS M B MANCILHA I M | 1988 | Journal of Industrial Microbiology1988，3，： | 1 |
| 12 | Automatic small bowel tumor diagnosis by u?sing multi-scale wavelet-based analysis in wireless cap?sule endoscopy images显示文摘 | Barbosa D C Roupar D B RamosJ C Tavares A C Li?rna C S | 2012 | Biomed Eng Online2012，11，： | 1 |
| 13 | Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expres- sion of MarA显示文摘 | Barbosa T M Levy S B | 2000 | J Bacheriol2000，182，12： | 1 |
| 14 | Multivariate analysis of nystatin and metronidazole in a semi-solid matrix by means of diffuse reflectance NIR spectroscopy and PLS regression 显示文摘 | Baratieri S C Barbosa J M Freitas M P | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，，40： | 1 |
| 15 | Utilization of sugar cane bagasse hemicellulosic hydrolyzate by Pichia stipitis for the production of ethanol显示文摘 | Roberto I C Lacis L S Barbosa M F S | 1991 | Proc Biochem1991，26，1： | 1 |
| 16 | Graph rigidity,cyclic belief propagation,and point pattern matching显示文摘 | McAuley J J Caetano T S and Barbosa M S | 2008 | IEEE Transactions on Pattern Analysis and Machine Intelligence2008，30，11： | 1 |
| 17 | Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery 显示文摘 | SOUTO E B WISSING S A BARBOSA C M | 2004 | Int J Pharm2004，278，1： | 1 |
| 18 | Leech-derived thrombin inhibitors: From structures to mechanisms to clinical aspplications 显示文摘 | Corral-Rodriguez M Macedo-Ribeiro S Barbosa Pereira P | 2010 | J Med Chem2010，53，10： | 1 |
| 19 | Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil 显示文摘 | POURIA S DE ANDRADE A BARBOSA J | 1998 | Lancet1998，352，9121： | 1 |
| 20 | Effects of the vitamin E in catalase activities in hippocampus after status epi- lepticus induced by pilocarpine in wistar rats显示文摘 | Barros D O Xavier S M L Barbosa C O etal | 2007 | Neuroscencei Letters2007，416，3： | 1 |
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